Magnetic Resonance Imaging Findings in Reye Syndrome

Singh, Paramdeep; Goraya, Jatinder S.; Gupta, Kamini; Saggar, Kavita; Ahluwalia, Archana

doi:10.1177/0883073810397047

Cited by 13 publications

(4 citation statements)

References 14 publications

(24 reference statements)

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“…MRI findings in children with Reye syndrome included high intensities in the thalamus, midbrain, pons, and cerebral and cerebellar white matter on T2-weighted or diffusionweighted images. [7][8][9] This distribution of brain lesions was similar to that in our patients. However, elevated serum ammonia levels and hypoglycemia are important markers of Reye syndrome.…”

Section: Discussionsupporting

confidence: 88%

Fulminant Encephalopathy with Marked Brain Edema and Bilateral Thalamic Lesions

et al. 2013

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We encountered two children with acute encephalopathy associated with unique clinical manifestations. Both the patients had status epilepticus at onset and neuroimaging studies revealed marked brain edema and bilateral thalamic lesions. Although they were treated with steroids and immunoglobulin, their outcomes were very poor. A thermolabile variant of carnitine palmitoyltransferase II and an elevated interleukin-6 level in cerebrospinal fluid were observed in one patient each. The constellation of clinical and neuroimaging findings in our patients is apparently not consistent with any established subtype of acute encephalopathy/encephalitis.

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Section: Discussionsupporting

confidence: 88%

Fulminant Encephalopathy with Marked Brain Edema and Bilateral Thalamic Lesions

et al. 2013

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“…Our imaging findings and diagnosis in this case is similar to the case described by Param et al . [ 17 ] They reported similar clinical and biochemical features in Reye's syndrome where MRI revealed diffuse cerebral edema with signal alterations and diffusion restriction in the brainstem, bilateral thalami, medial temporal lobes, parasagittal cortex, cerebellar, and subcortical white matter.…”

Section: Discussionmentioning

confidence: 91%

A prospective study of magnetic resonance imaging patterns of central nervous system infections in pediatric age group and young adults and their clinico-biochemical correlation

Gupta¹,

Banerjee²,

Saggar³

et al. 2016

J Pediatr Neurosci

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Background:Infections of the central nervous system (CNS) are common and routinely encountered. Our aim was to evaluate the neuroimaging features of the various infections of the CNS so as to differentiate them from tumoral, vascular, and other entities that warrant a different line of therapy.Aims:Our aim was to analyze the biochemical and magnetic resonance imaging (MRI) features in CNS infections.Settings and Design:This was a longitudinal, prospective study over a period of 1½ years.Subjects and Methods:We studied cerebrospinal fluid (CSF) findings and MRI patterns in 27 patients of 0–20 years age group with clinical features of CNS infections. MRI was performed on MAGNETOM Avanto 18 Channel 1.5 Tesla MR machine by Siemens India Ltd. The MRI protocol consisted of diffusion-weighted and apparent diffusion coefficient imaging, turbo spin echo T2-weighted, spin echo T1-weighted, fluid-attenuated inversion recovery (FLAIR), and gradient-echo in axial, FLAIR in coronal, and T2-weighted in sagittal plane. Contrast-enhanced T1-weighted sequence and MR spectroscopy were done whenever indicated.Results and Conclusions:We found that most of the children belong to 1–10 years age group. Fungal infections were uncommon, mean CSF adenosine deaminase values specific for tuberculosis and mean CSF glucose-lowered in pyogenic. Hemorrhagic involvement of thalamus with/without basal ganglia and brainstem involvement may indicate Japanese encephalitis or dengue encephalitis. Diffusion restriction or hemorrhage in not expected in the brainstem afflicted lesions of rabies. Congenital cytomegalovirus can cause cortical malformations. T1 hyperintensities with diffusion restriction may represent viral encephalitis. Lesions of acute disseminated encephalomyelitis (ADEM) may mimic viral encephalitis. Leptomeningeal enhancement is predominant in pyogenic meningitis. Basilar meningitis in the presence of tuberculomas is highly sensitive and specific for tuberculosis.

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“…Clinically, symptoms are similar, such as fever, headache, and signs of encephalopathy. Nevertheless, the clinical course in ADEM tends to be more gradual compared to the rapid onset seen in ANEC [ 10 ]. Acute necrotizing encephalopathy of childhood represents a serious and often lethal complication, with prognosis varying from complete recovery to death within days of admission, irrespective of treatment.…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Acute Necrotizing Encephalopathy of Childhood: A Case Report

Bothara,

Dhande,

et al. 2024

Cureus

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Acute necrotizing encephalopathy of childhood (ANEC) is a severe neurological disorder characterized by rapid-onset encephalopathy, often associated with viral infections. Acute necrotizing encephalopathy of childhood is associated with a very high mortality rate, and survivors may face long-term neurological sequelae. Acute necrotizing encephalopathy of childhood needs to be differentiated from its closest differential diagnosis, acute disseminated encephalomyelitis (ADEM). Most of the patients with ADEM recover, with a few of them having residual neurological deficits. We present a case of an eight-year-old boy with an acute history of fever, febrile seizures, and drowsiness. Magnetic resonance imaging revealed a symmetric tricolor appearance of bilateral thalamic lesions, characteristic of ANEC.

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Magnetic Resonance Imaging Findings in Reye Syndrome

Cited by 13 publications

References 14 publications

Fulminant Encephalopathy with Marked Brain Edema and Bilateral Thalamic Lesions

Fulminant Encephalopathy with Marked Brain Edema and Bilateral Thalamic Lesions

A prospective study of magnetic resonance imaging patterns of central nervous system infections in pediatric age group and young adults and their clinico-biochemical correlation

A Rare Case of Acute Necrotizing Encephalopathy of Childhood: A Case Report

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