Reye's syndrome and aspirin use: A possible imuunological relationship

Aspirin and immune system

“…Conversely, collateral evidences from prior research indicate that ASA may promote T cell function by increasing their activation or proliferation [110][111][112][113][114]. This is also worthy of note that ASA can induce IFN-γ production typical of T cell phenotypes [115][116][117], which suggests that ASA may enhance T cell effector responses.…”

Eicosanoids and aspirin in immune cell function

“…A considerable amount of evidence has accumulated concentrations has been shown to stimulate mitogenesis in spleen cell populations by up to 300% . 26 This has been suggested as an underlying factor in the aberrant host-virus interaction which leads to Reye's syndrome. The stimulation of mitogenesis induced by aspirin can be reversed by low concentrations of PGE, (Fig.…”

Viscosine as a Potent and Safe Antipyretic Agent Evaluated by Yeast-Induced Pyrexia Model and Molecular Docking Studies

“…10 Their prolonged use in children and adolescents may lead to Reye’s syndrome (liver damage). 11 Prolonged use of selective COX-2 inhibitors, particularly NSAIDs, is linked with higher risks of cardiac attack 12,13 and stroke, and patients with kidney, heart, or liver conditions are at risk of developing kidney damage. 14 The long-term use of cyclooxygenase inhibitors as antipyretic agents is associated with serious side effects.…”

“…Nonselective COX inhibitors are harmful to the gastrointestinal tract causing gastric distress, ulceration, and other bleeding disorders . Their prolonged use in children and adolescents may lead to Reye’s syndrome (liver damage) . Prolonged use of selective COX-2 inhibitors, particularly NSAIDs, is linked with higher risks of cardiac attack , and stroke, and patients with kidney, heart, or liver conditions are at risk of developing kidney damage .…”