Rewarding effect of ethanol-induced conditioned place preference in mice: Effect of the monoterpenoid linalool

Yunusoğlu, Oruç

doi:10.1016/j.alcohol.2021.11.003

Cited by 3 publications

(9 citation statements)

References 75 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Systemic ethanol administration alone and in combination with myricetin did not alter locomotor activity and motor coordination. Drug doses were selected based on similar prior examinations [25][26][27][28]. These results are consistent with other published conclusions [25,29].…”

Section: Discussionsupporting

confidence: 71%

“…Despite the shown study delivering interesting findings and casting novel light on the vulnerability factors contributory to ethanol addiction, we identified some limitations that should be taken into consideration and developed in future investigations [26,42,43]. It should be highlighted that these experiments were performed on male mice.…”

Section: Groupsmentioning

confidence: 99%

“…Alcohol craving and seeking have been mainly related to glutamatergic changes in the brain reward system [30]. In various studies, the various pharmacological molecular inhibiting glutamatergic system reduced alcohol addiction [26,30]. It has been previously demonstrated in different studies that Myricetin inhibits the glutamatergic system [8,30,34].…”

Section: Groupsmentioning

confidence: 99%

“…A strategy to combine the approaches of precipitating the extinction development and reducing the motivational influence of substance-associated triggers on behavior might be the most beneficial and clinically useful for achieving a robust and ongoing suppression of relapse behaviors [45]. Based on the principles of classical conditioned extinction and learning, cue exposure therapy involves replicated exposure to drugs-associated or substance-associated cues to extinguish conditioned seeking or cravings and decrease the likelihood of relapse [26]. In common, the therapeutic agents evaluated in animal (e.g., mice, rats, monkeys, etc.,) models for relapse, target brain mechanisms that keenly control drug-craving and drugcraving seeking induced by relapse-recurrent effects [26,46,47].…”

Section: Groupsmentioning

confidence: 99%

“…Based on the principles of classical conditioned extinction and learning, cue exposure therapy involves replicated exposure to drugs-associated or substance-associated cues to extinguish conditioned seeking or cravings and decrease the likelihood of relapse [26]. In common, the therapeutic agents evaluated in animal (e.g., mice, rats, monkeys, etc.,) models for relapse, target brain mechanisms that keenly control drug-craving and drugcraving seeking induced by relapse-recurrent effects [26,46,47]. The primary recovery strategy for any substance abuse contains management of acute withdrawal (detoxification), abstinence initiation, and relapse prevention [48].…”

Section: Groupsmentioning

confidence: 99%

See 4 more Smart Citations

Investigation of the pharmacological potential of myricetin on alcohol addiction in mice

Yunusoğlu¹,

SHAHZADI²,

Türel³

et al. 2022

jrp

Self Cite

View full text Add to dashboard Cite

Alcohol addiction is one of the leading causes which is associated with morbidity and mortality with outcomes in high healthcare and economic costs. Myricetin is a flavonoid that demonstrates therapeutic actions in many central nervous system diseases. In the current study, the conditioned place preference (CPP) tests were performed to examine the effects of myricetin on ethanol reward. During conditioning, intraperitoneal (i.p) administration of ethanol (2 g/kg) and serum physiologic were given on alternate days for 8 days. In order to evaluate the effect of myricetin on the development of alcohol addiction, myricetin was injected into mice 30 minutes before ethanol administration. Subsequently, a daily myricetin injection was performed to evaluate the effect of myricetin on the extinction of alcohol addiction. Finally, ethanol was administered 900 seconds after different dose myricetin administration, and reinstatement was evaluated immediately thereafter. Systemic ethanol (2 g/kg, i.p) administration significantly produced CPP. Myricetin (5 and 10 mg/kg, i.p) attenuated the development of ethanol addiction (p < 0.05). Systemic myricetin injections immediately after each extinction period precipitated extinction and decreased reinstatement (10 mg/kg, i.p, p < 0.05, respectively). Ethanol alone and in combination with myricetin did not change locomotor activity and motor coordination. As a result, it can be suggested that myricetin is effective in attenuating the rewarding effect of alcohol in mice and can be used for the adjunctive therapy for alcohol addiction. In addition, it will be appropriate to conduct mechanistic experimental studies regarding these results in the future.

show abstract

Section: Discussionsupporting

confidence: 71%

Section: Groupsmentioning

confidence: 99%

Section: Groupsmentioning

confidence: 99%

Section: Groupsmentioning

confidence: 99%

Section: Groupsmentioning

confidence: 99%

See 3 more Smart Citations

Investigation of the pharmacological potential of myricetin on alcohol addiction in mice

Yunusoğlu¹,

SHAHZADI²,

Türel³

et al. 2022

jrp

Self Cite

View full text Add to dashboard Cite

show abstract

Investigation of the impact of antiparasitic drug moxidectin on the rewarding effects of alcohol

Ekici¹,

Gürbüz²,

Berköz³

et al. 2022

gpb

View full text Add to dashboard Cite

Sıçanlarda Bupropion ve Vareniklinin Morfin Yoksunluğu Sendromu Üzerine Etkileri

Yunusoğlu

KÖSE

ÖZYAZGAN³

et al. 2022

Abant Med J

Self Cite

View full text Add to dashboard Cite

Objective: Opioid dependence is a chronic and complex disorder characterized by relapse and remission. Chronic administration of morphine causes symptoms of physical and psychological dependence. The purpose of the present study was to investigate the effect of anti-addictive drugs such as bupropion and varenicline on morphine dependence and naloxone precipitated withdrawal syndrome in a rat model. Materials and Methods: To assess the physical dependence of morphine, Wistar albino rats were intraperitoneal (i.p.) administered increasing doses of morphine twice daily for 5 days, 4 hours after a single dose of morphine on day 6, and 15 minutes before subcutaneous (s.c.) naloxone (2 mg/kg, s.c.) administration to elicit withdrawal symptoms. Physical dependence was evaluated by giving intraperitoneal bupropion (5, 10 and 20 mg/kg, i.p.) and varenicline (0.5. 1 and 2 mg/kg, s.c) for 15 minutes. Results: The morphine-dependent rats had significantly more withdrawal symptoms than naive control rats. The results demonstrated administration of bupropion and varenicline during induction of morphine dependence attenuated the most of the severity of withdrawal symptoms. Co-administration of bupropion reduced withdrawal symptoms such as jumping, wet dog shaking, weight loss and total withdrawal symptoms. Co-administration of varenicline was found to be effective on withdrawal symptoms such as bupropion, but had no effect on weight loss. Conclusion: These outcomes provide preliminary data that bupropion and varenicline could be used as a candidate drugs to attenuate morphine withdrawal symptoms.

show abstract

Rewarding effect of ethanol-induced conditioned place preference in mice: Effect of the monoterpenoid linalool

Cited by 3 publications

References 75 publications

Investigation of the pharmacological potential of myricetin on alcohol addiction in mice

Investigation of the pharmacological potential of myricetin on alcohol addiction in mice

Investigation of the impact of antiparasitic drug moxidectin on the rewarding effects of alcohol

Sıçanlarda Bupropion ve Vareniklinin Morfin Yoksunluğu Sendromu Üzerine Etkileri

Contact Info

Product

Resources

About