Reward sensitivity in depression: A biobehavioral study.

Shankman, Stewart A.; Klein, Daniel N.; Tenke, Craig E.; Bruder, Gerard E.

doi:10.1037/0021-843x.116.1.95

Cited by 118 publications

(136 citation statements)

References 74 publications

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“…Second, anhedonia, or reduced capacity to experience pleasure or PA from events or activities that are normally rated as interesting or pleasant, is a core symptom of depression. There is experimental evidence showing lower levels of PA in depressed patients (Clark et al, 1994), decreased reward sensitivity toward positive stimuli (Sloan et al, 1997;Dunn et al, 2004;Shankman et al, 2007), and altered reward-related decision making (Forbes et al, 2007). Taken together, the findings suggest that depressed individuals show altered Stress-Sensitivity together with a diminished ability to make use of natural rewards generating positive emotions.…”

Section: Introductionmentioning

confidence: 61%

Reduced Stress-Sensitivity or Increased Reward Experience: The Psychological Mechanism of Response to Antidepressant Medication

Wichers

Barge-Schaapveld

Nicolson

et al. 2008

Neuropsychopharmacol

121

123

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Depression has often been associated with increased negative affect reactivity to stress (Stress-Sensitivity) and reduced capacity to experience pleasure or positive affect (Reward Experience). To date, no studies have prospectively examined changes in StressSensitivity and Reward Experience following antidepressant treatment. The sample included 83 depressed patients and 22 healthy controls. A randomized controlled trial was carried out with patients receiving either imipramine or placebo for 6 weeks. At baseline and 6 weeks, patients and controls participated in an Experience Sampling procedure, prospectively measuring ecologically valid daily life appraisals of activities and mood states. The course of depression was assessed with the Hamilton Depression Rating Scale (HDRS). Multilevel linear regression analyses showed that patients had higher negative and lower positive appraisals of activities than controls. In addition, patients showed increased Stress-Sensitivity (negative affect reactivity to negatively appraised activities). Treatment with imipramine decreased Stress-Sensitivity and increased Reward Experience (positive affect reactivity to positively appraised activities). Changes in Stress-Sensitivity and Reward Experience were in part reducible to changes in the process of activity appraisal itself. However, increase in Reward Experience, but not decrease in Stress-Sensitivity, discriminated between patients who responded and those who did not, independent of changes in the process of activity appraisal itself. Response to treatment in depression may be conditional on restoration of hedonic capacity, the cerebral substrate of which requires further study in relation to antidepressant response. A search for (synergistic) antidepressant therapies specifically targeting ability to experience reward may be warranted.

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Section: Introductionmentioning

confidence: 61%

Reduced Stress-Sensitivity or Increased Reward Experience: The Psychological Mechanism of Response to Antidepressant Medication

Wichers

Barge-Schaapveld

Nicolson

et al. 2008

Neuropsychopharmacol

121

123

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“…Most of these brain imaging studies concerned patients with major depression but also recovered depressed (McCabe, Cowen, & Harmer, 2009) and healthy populations at risk (Gotlib et al, 2010). In a similar vein, there is evidence for electrocortical hypoactivation of left prefrontal areas in depressed and dysphoric individuals-in the resting state but also during reward anticipation (e.g., Davidson, Pizzagalli, Nitschke, & Putnam, 2002;Gotlib, Ranganath, & Rosenfeld, 1998;Harmon-Jones et al, 2002;Shankman, Klein, Tenke, & Bruder, 2007;Thibodeau, Jorgensen, & Kim, 2006;Tomarken & Keener, 1998).…”

Section: Reward Insensitivity In Depression and Dysphoriamentioning

confidence: 94%

Not everyone's heart contracts to reward: Insensitivity to varying levels of reward in dysphoria

Brinkmann

Franzén

2013

Biological Psychology

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Reward insensitivity in depression and dysphoria has been demonstrated by selfreport, behavioral, and neuroscience data. These findings show less anticipated and experienced pleasure to rewarding stimuli, no behavioral adaptation in anticipation of rewards, and altered functioning in reward-related brain areas. The present study expands previous research by using cardiovascular reactivity to three levels of reward as an indicator of effort mobilization. Undergraduates with low versus high depression scores worked on a cognitive task in anticipation of no, versus a small, versus a significant amount of money for successful task performance. Results of pre-ejection period and heart rate reactivity confirmed the expected linear increase as a function of reward value in nondysphoric participants and the expected blunted response across all reward levels in dysphoric participants. The present findings thus show that dysphoric individuals have a motivational deficit in terms of reduced effort-related cardiac reactivity when anticipating a monetary reward.

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“…(Sherdell et al 2012). In addition, individuals with depression or with a family history of depression show reduced frontal EEG asymmetries during reward anticipation (Shankman et al 2007(Shankman et al , 2013Nelson et al 2013Nelson et al , 2014. Further, a recent meta-analysis on neural processing of rewards in depression found evidence for <reduced>?…”

Section: Reward Anticipationmentioning

confidence: 97%

Mechanisms Underlying Motivational Deficits in Psychopathology: Similarities and Differences in Depression and Schizophrenia

Deanna¹,

Pagliaccio²,

Luking³

2015

Behavioral Neuroscience of Motivation

178

148

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Motivational and hedonic impairments are core aspects of a variety of types of psychopathology. These impairments cut across diagnostic categories and may be critical to understanding major aspects of the functional impairments accompanying psychopathology. Given the centrality of motivational and hedonic systems to psychopathology, the Research Domain Criteria (RDoC) initiative includes a "positive valence" systems domain that outlines a number of constructs that may be key to understanding the nature and mechanisms of motivational and hedonic impairments in psychopathology. These component constructs include initial responsiveness to reward, reward anticipation or expectancy, incentive or reinforcement learning, effort valuation, and action selection. Here, we review behavioral and neuroimaging studies providing evidence for impairments in these constructs in individuals with psychosis versus in individuals with depressive pathology. There are important differences in the nature of reward-related and hedonic deficits associated with psychosis versus depression that have major implications for our understanding of etiology and treatment development. In particular, the literature strongly suggests the presence of impairments in in-the-moment hedonics or "liking" in individuals with depressive pathology, particularly among those who experience anhedonia. Such deficits may propagate forward and contribute to impairments in other constructs that are dependent on hedonic responses, such as anticipation, learning, effort, and action selection. Such hedonic impairments could reflect alterations in dopamine and/or opioid signaling in the striatum related to depression or specifically to anhedonia in depressed populations. In contrast, the literature points to relatively intact in-the-moment hedonic processing in psychosis, but provides much evidence for impairments in other components involved in translating reward to action selection. Particularly, individuals with schizophrenia exhibit altered reward prediction and associated striatal and prefrontal activation, impaired reward learning, and impaired reward-modulated action selection.

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Reward sensitivity in depression: A biobehavioral study.

Cited by 118 publications

References 74 publications

Reduced Stress-Sensitivity or Increased Reward Experience: The Psychological Mechanism of Response to Antidepressant Medication

Reduced Stress-Sensitivity or Increased Reward Experience: The Psychological Mechanism of Response to Antidepressant Medication

Not everyone's heart contracts to reward: Insensitivity to varying levels of reward in dysphoria

Mechanisms Underlying Motivational Deficits in Psychopathology: Similarities and Differences in Depression and Schizophrenia

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