Reward sensitivity, affective neuroscience personality, symptoms of attention-deficit/hyperactivity disorder, and<i>TPH2</i>-703G/T (rs4570625) genotype

Pulver, Aleksander; Kiive, Evelyn; Harro, Jaanus

doi:10.1017/neu.2020.18

Cited by 5 publications

(13 citation statements)

References 82 publications

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“…The ROIS scale [28], was used to assess the relationship between reward sensitivity and measures of obesity from 9 to 33 years of age. We observed that higher Insatiability by Reward We demonstrated that Insatiability by Reward and more specifically the Giving in to Cravings subscale scores were significantly lower in female TFAP2B 4/4 homozygotes compared to heterozygotes and 5/5 homozygotes.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, the results cannot be extrapolated to other ethnicities. Secondly, the ROIS instrument [28], used for the assessment of reward sensitivity, was developed post hoc, applied in a Finnic language, and requires further development and characterization together with related instruments;…”

Section: Discussionmentioning

confidence: 99%

Section: Reward Sensitivitymentioning

confidence: 99%

“…Reward sensitivity was assessed using the Reward Openness and Insatiability Scale (ROIS), which specifies the inner structure of reward sensitivity [28]. The construction and description of ROIS has been described in detail elsewhere [28]. In brief, ROIS comprises of 28 items, divided equally between two higher-order factors -Openness to Rewards, a strive toward multiplicity of rewards and Insatiability by Reward, characterized by an excessive fixation to a particular reward.…”

Section: Reward Sensitivitymentioning

confidence: 99%

“…The inner structure of reward sensitivity has not been sufficiently understood [26,27] and the association of components of reward sensitivity with body weight remains unexplored. We have recently been able to differentiate reward sensitivity into Openness to Rewards, the strive towards multiplicity of rewards, and Insatiability by Reward, a fixation to a particular reward [28]. These two aspects of reward sensitivity diverge in their relationship with basic personality dimensions and symptoms of attention deficit hyperactivity disorder (ADHD), a condition that is often co-morbid with obesity [29].…”

Section: Introductionmentioning

confidence: 99%

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The role of reward sensitivity in obesity and its association with Transcription Factor AP-2B: A longitudinal birth cohort study

Katus

Villa

Ringmets

et al. 2020

Neuroscience Letters

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Objective: One factor potentially contributing to obesity is reward sensitivity. We investigated the association between reward sensitivity and measures of obesity from 9 to 33 years of age, paying attention to the inner structure of reward sensitivity. Methods:The sample included both birth cohorts (originally n = 1176) of the Estonian Children Personality Behaviour and Health Study. The association between reward sensitivity and measures of obesity was assessed using mixed-effects regression models. Associations at ages 9 (younger cohort only), 15, 18, 25 and 33 (older cohort) years were analyzed by one-way ANOVA. The indirect effect of the gene encoding transcription factor 2 beta (TFAP2B) on obesity through reward sensitivity was tested using mediation analysis.Results: According to linear mixed effects regression models, an increase in scores of Insatiability by Reward and both of its components, Excessive Spending and Giving in to Cravings, significantly increased body weight, body mass index, sum of five skinfolds, waist circumference, hip circumference and waist-to-height ratio from 15 to 25 years of age.Findings were similar at age 9 and 33 years. In contrast, no association between obesity and Openness to Rewards or its facets was observed. The TFAP2B genotype was also associated with fixation to rewards in females, but not with striving towards reward multiplicity. Conclusion:Our results suggest that reward sensitivity is associated with obesity by its reward fixation component. The heterogeneity of the reward sensitivity construct should be taken into account in studies on body composition.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Reward Sensitivitymentioning

confidence: 99%

Section: Reward Sensitivitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The role of reward sensitivity in obesity and its association with Transcription Factor AP-2B: A longitudinal birth cohort study

Katus

Villa

Ringmets

et al. 2020

Neuroscience Letters

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Association of orexin/hypocretin receptor gene (HCRTR1) with reward sensitivity, and interaction with gender

et al. 2020

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Orexins/hypocretins maintain wakefulness, increase appetite and participate in the coordination of stress response. We have recently provided evidence on the role of orexins in aggression, showing the association of the HCRTR1 genotype (rs2271933 G>A; leading to amino acid substitution Ile408Val) with aggressiveness or breach of law in four independent cohorts. Aggressive behaviour can be reward driven and hence we have examined the association of HCRTR1 rs2271933 genotype with different aspects of reward sensitivity in the birth cohort representative Estonian Children Personality Behaviour and Health Study. HCRTR1 genotype was associated with reward sensitivity in a gender dependent manner. Male HCRTR1 A/A homozygotes had higher Openness to Rewards and the overall reward sensitivity score while, in contrast, female A/A homozygotes scored lower than G-allele carriers in Openness to Rewards. In the 2 total sample, aggressiveness correlated positively with reward sensitivity, but this was on account of Insatiability by Reward. In contrast, the HCRTR1 A/A homozygotes had a positive association of aggressiveness and Openness to Rewards. Experience of stressful life events had a small but significant increasing effect on both aspects of reward sensitivity, and correlated in an anomalous way with reward sensitivity in the HCRTR1 A/A homozygotes. Conclusively, the higher aggressiveness of HCRTR1 A/A homozygotes appears based on a qualitative difference in sensitivity to rewards, in the form that suggests their lower ability to prevent responses to challenges being converted into overt aggression.

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The Chinese version of the Barcelona Music Reward Questionnaire (BMRQ): Associations with personality traits and gender

Wang¹,

Xu²,

Jin³

et al. 2021

Musicae Scientiae

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Sensitivity to music reward varies across individuals. The Barcelona Music Reward Questionnaire (BMRQ) is an effective tool in the assessment of sensitivity to music reward. The current study investigated the psychometric properties of the Chinese version of the BMRQ, including its internal consistency, factor structure, criterion-related validity, and measurement invariance across gender. In addition, the relationship between personality traits and sensitivity to music reward was explored. A total of 1,120 Chinese undergraduate students completed a pen-and-paper version of the BMRQ, either in individual sessions or in class groups. Confirmatory factor analysis indicated a good fit for the revised model of the BMRQ. In addition, good internal consistency reliability of the overall scale and criterion-related validity with the BIS/BAS scale were also supported in this study. Evidence of configural, metric, and scalar invariance supported its measurement invariance across gender. On this basis, women in our sample reported themselves more sensitive than men to music reward. Results also showed that the personality traits Openness to Experience and Agreeableness were the strongest contributors to music reward sensitivity, while Extraversion did not make a significant contribution. These findings may provide a reference point for therapists wishing to predict the efficacy of music therapy for individuals.

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Reward sensitivity, affective neuroscience personality, symptoms of attention-deficit/hyperactivity disorder, andTPH2-703G/T (rs4570625) genotype

Cited by 5 publications

References 82 publications

The role of reward sensitivity in obesity and its association with Transcription Factor AP-2B: A longitudinal birth cohort study

The role of reward sensitivity in obesity and its association with Transcription Factor AP-2B: A longitudinal birth cohort study

Association of orexin/hypocretin receptor gene (HCRTR1) with reward sensitivity, and interaction with gender

The Chinese version of the Barcelona Music Reward Questionnaire (BMRQ): Associations with personality traits and gender

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