Reward anticipation revisited- evidence from an fMRI study in euthymic bipolar I patients and healthy first-degree relatives

Kollmann, Bianca; Scholz, Vanessa; Linke, Julia; Kirsch, Peter; Wessa, Michèle

doi:10.1016/j.jad.2017.04.044

Cited by 25 publications

(14 citation statements)

References 35 publications

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“…For example, loss anticipation was characterized by lower ventral striatum (VS) activation (Yip et al ., 2015) and sparser frontal-striatal-parietal functional connectivity in individuals with BD v. HC (Manelis et al ., 2016). Reward anticipation in BD was characterized by increased VS (Nusslock et al ., 2012), left ventrolateral PFC (Chase et al ., 2013) and anterior cingulate cortical (Kollmann et al ., 2017) activation in some studies, but decreased VS activation (Schreiter et al ., 2016) in other studies. Greater depressive symptom severity was related to lower VS activation during reward anticipation across psychiatric diagnoses including BD (Hägele et al ., 2015).…”

Section: Introductionmentioning

confidence: 91%

Longitudinal changes in brain activation during anticipation of monetary loss in bipolar disorder

et al. 2018

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BackgroundIndividuals with bipolar disorder (BD) show aberrant brain activation patterns during reward and loss anticipation. We examined for the first time longitudinal changes in brain activation during win and loss anticipation to identify trait markers of aberrant anticipatory processing in BD.MethodsThirty-four euthymic and depressed individuals with BD-I and 17 healthy controls (HC) were scanned using functional magnetic resonance imaging twice 6 months apart during a reward task.ResultsHC, but not individuals with BD, showed longitudinal reductions in the right lateral occipital cortex (RLOC) activation during processing of cues predicting possible money loss (p-corrected <0.05). This result was not affected by psychotropic medication, mood state or the changes in depression/mania severity between the two scans in BD. Elevated symptoms of subthreshold hypo/mania at baseline predicted more aberrant longitudinal patterns of RLOC activation explaining 12.5% of variance in individuals with BD.ConclusionsIncreased activation in occipital cortex during negative outcome anticipation may be related to elevated negative emotional arousal during anticipatory cue processing. One interpretation is that, unlike HC, individuals with BD were not able to learn at baseline that monetary losses were smaller than monetary gains and were not able to reduce emotional arousal for negative cues 6 months later. Future research in BD should examine how modulating occipital cortical activation affects learning from experience in individuals with BD.

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Section: Introductionmentioning

confidence: 91%

Longitudinal changes in brain activation during anticipation of monetary loss in bipolar disorder

et al. 2018

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“…In particular, the VS plays a key role in encoding expected positive incentive value (Abler et al, 2006;Bjork et al, 2010aBjork et al, , 2008aKnutson et al, 2001a;Mucci et al, 2015). Moreover, monetary reward anticipation further engages the anterior insula (AI) and dorsal anterior cingulate cortex/supplementary motor area (dACC/SMA), which are implicated in signaling salience of an upcoming event (Funayama et al, 2014;Kirk et al, 2015;Kollmann et al, 2017;Oldham et al, 2018;Wilson et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

“…Building on previous findings, many recent studies have employed a social variant of the MID (here forth social incentive delay [SID]) task to examine neural signatures of social reward anticipation. In the SID task, social stimuli that are intrinsically rewarding, such as smiling faces, "thumbs-up" gestures, positive verbal messages, were employed as incentives (Goerlich et al, 2017;Kollmann et al, 2017;Spreckelmeyer et al, 2009). Evidence has shown that social reward anticipation recruits both overlapping and distinct neural circuits compared to monetary reward anticipation.…”

Section: Introductionmentioning

confidence: 99%

Love is analogous to money in human brain: Coordinate-based and functional connectivity meta-analyses of social and monetary reward anticipation

Huang

Camilleri

et al. 2019

Neuroscience & Biobehavioral Reviews

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Both social and material rewards play a crucial role in daily life and function as strong incentives for various goal-directed behaviors. However, it remains unclear whether the incentive effects of social and material reward are supported by common or distinct neural circuits. Here, we have addressed this issue by quantitatively synthesizing and comparing neural signatures underlying social (21 contrasts, 207 foci, 696 subjects) and monetary (94 contrasts, 1083 foci, 2060 subjects) reward anticipation. We demonstrated that social and monetary reward anticipation engaged a common neural circuit consisting of the ventral tegmental area, ventral striatum, anterior insula, and supplementary motor area, which are intensively connected during both task and resting states. Functional decoding findings indicate that this generic neural pathway mediates positive value, motivational relevance, and action preparation during reward anticipation, which together motivate individuals to prepare well for the response to the upcoming target. Our findings support the *

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“…Study design might play a role, since studies reporting increased NAcc activity during reward in individuals with bipolar disorder tended to use card guessing or roulette tasks (Caseras et al, 2013; Mason et al, 2014; Nusslock et al, 2014), whereas studies reporting decreased NAcc activity tended to use Monetary Incentive Delay (or MID) tasks (O'Sullivan et al, 2011; Schreiter et al, 2016). Other methodological reasons for variation might include smaller sample sizes (e.g., fewer than 20 per group (Abler et al, 2008; Berghorst et al, 2016; Bermpohl et al, 2010; Kollmann et al, 2017; Linke et al, 2012; Mason et al, 2014; Nusslock et al, 2012; O'Sullivan et al, 2011; Schreiter et al, 2016; Singh et al, 2013; Trost et al, 2014; Urošević et al, 2016; Yip et al, 2015)), insufficiently large incentives to increase NAcc activity in healthy controls (Nusslock et al, 2012), or the lack of neutral or loss conditions for comparison (Nusslock et al, 2012). Thus, while some FMRI evidence implies abnormalities in the neural processing of incentives in bipolar disorder, the direction and strength of these effects remains unclear.…”

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confidence: 99%

Neural responses to monetary incentives in bipolar disorder

Johnson

Mehta

Ketter

et al. 2019

NeuroImage: Clinical

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HighlightsCompared with control participants, participants with bipolar disorder showed blunted NAcc activity during monetary gain anticipation.Blunted NAcc activity during gain anticipation is related to individual differences in the tendency to respond impulsively to positive emotional states (Positive Urgency).Individual differences in Positive Urgency could statistically account for the association of blunted NAcc activity with bipolar diagnosis.

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Reward anticipation revisited- evidence from an fMRI study in euthymic bipolar I patients and healthy first-degree relatives

Cited by 25 publications

References 35 publications

Longitudinal changes in brain activation during anticipation of monetary loss in bipolar disorder

Longitudinal changes in brain activation during anticipation of monetary loss in bipolar disorder

Love is analogous to money in human brain: Coordinate-based and functional connectivity meta-analyses of social and monetary reward anticipation

Neural responses to monetary incentives in bipolar disorder

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