Reward and relief craving tendencies in patients with alcohol use disorders: Results from the PREDICT study

Glöckner-Rist, Angelika; Leménager, Tagrid; Mann, Karl

doi:10.1016/j.addbeh.2012.06.018

Cited by 51 publications

(48 citation statements)

References 32 publications

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“…It is noteworthy that only 20% of Relapsers who met criteria for MDD were taking an antidepressant at the time of study. Collectively, the above suggests that individuals with AUD and comorbid unipolar mood disorders may be at increased risk for relapse to hazardous alcohol consumption in order to attenuate negative mood and/or subjectively enhance mood (Glockner-Rist et al, 2013). …”

Section: Discussionmentioning

confidence: 99%

Psychiatric, Demographic, and Brain Morphological Predictors of Relapse After Treatment for an Alcohol Use Disorder

Durazzo

Meyerhoff

2016

Alcoholism Clin & Exp Res

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Background Relapse in alcohol use disorders (AUD) is related to a complex interplay among multiple biological, psychiatric, psychological and psychosocial factors, which may change dynamically during and after treatment. At treatment entry for AUD, morphological abnormalities in anterior frontal regions and the insula have been observed in those who ultimately relapse following treatment. The goal of this study was to determine if measures anterior frontal and insula measures of regional brain thickness, surface area and volume predict post-treatment drinking status (i.e., relapser or abstainer) over an extended period after outpatient treatment for AUD, while concurrently considering common psychiatric, psychological and psychosocial factors previously associated with relapse. Methods Alcohol dependent individuals (n = 129) were followed for 18 months after treatment to determine post-treatment drinking status [Abstainers (n = 47) or Relapsers (n = 82)]. Brain morphometrics were derived from FreeSurfer. Receiver operator characteristic (ROC) curve analysis was used to identify the regional brain thickness, surface area and volume (all scaled to intracranial volume), demographic, psychiatric, other substance use (e.g., cigarette smoking) and alcohol consumption variables, obtained at entry into treatment, that best predicted post-treatment drinking status. Survival analyses determined variables that were related to duration of abstinence after treatment. Results ROC analyses indicated that mood disorders, education, and volumes of the right caudal ACC, right rostral ACC and total right frontal gray matter were significant predictors of post-treatment drinking status. Among Relapsers, survival analyses showed smokers and individuals with a comorbid medical condition relapsed earlier after treatment. Additionally, a greater frequency of smokers relapsed within 6 months of treatment. Conclusions Results reinforce that relapse in AUD is a function of multiple biological, psychiatric, psychological and psychosocial factors. Effective treatment of depressive disorders and cigarette smoking concurrent with AUD-focused interventions may promote better treatment outcomes.

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Section: Discussionmentioning

confidence: 99%

Psychiatric, Demographic, and Brain Morphological Predictors of Relapse After Treatment for an Alcohol Use Disorder

Durazzo

Meyerhoff

2016

Alcoholism Clin & Exp Res

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“…There are preliminary studies on the Amsterdam Motives for Drinking Scale (Ooteman, Koeter, Verheul, Schippers, & van Den Brink 2006), the Craving Typology Questionnaire (Martinotti et al . 2013), the Reasons for Heavy Drinking Questionnaire (Adams, Schacht, Randall, & Anton, 2016), the Alcohol Abstinence Self-Efficacy Scale (AASE; Glöckner-Rist et al . 2013), and the Reward-Relief Drinking Scale (RRDS; Mann & Nakovics under review) as self-report methods for identifying reward/relief drinking tendencies.…”

Section: Introductionmentioning

confidence: 99%

Reward and relief dimensions of temptation to drink: construct validity and role in predicting differential benefit from acamprosate and naltrexone

2016

Self Cite

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Researchers have sought to distinguish between individuals whose alcohol use disorder (AUD) is maintained by drinking to relieve negative affect (“relief drinkers”) and those whose AUD is maintained by the rewarding effects of alcohol (“reward drinkers”). As an opioid receptor antagonist, naltrexone may be particularly effective for reward drinkers. Acamprosate, which has been shown to down-regulate the glutamatergic system, may be particularly effective for relief drinkers. This study sought to replicate and extend prior work (PREDICT study; Glöckner-Rist et al. 2013) by examining dimensions of reward and relief temptation to drink and subtypes of individuals with distinct patterns of reward/relief temptation. We utilized data from two randomized clinical trials for AUD (Project MATCH, n=1726 and COMBINE study, n=1383). We also tested whether classes of reward/relief temptation would predict differential response to naltrexone and acamprosate in COMBINE. Results replicated prior work by identifying reward and relief temptation factors, which had excellent reliability and construct validity. Using factor mixture modeling, we identified 5 distinct classes of reward/relief temptation that replicated across studies. In COMBINE, we found a significant class-by-acamprosate interaction effect. Among those most likely classified in the high relief/moderate reward temptation class, individuals had better drinking outcomes if assigned to acamprosate versus placebo. We did not find a significant class-by-naltrexone interaction effect. Our study questions the orthogonal classification of drinkers into only two types (reward or relief drinkers) and adds to the body of research on moderators of acamprosate, which may inform clinical decision making in the treatment of AUD.

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“…Few studies that have tried to disentangle the subjective experience of craving from reported temptation to drink (Ooteman, Koeter, Vserhuel, Schippers, & van den Brink, 2006); however, one recent study found the Temptation scale of the Alcohol Abstinence Self-Efficacy Scale (DiClemente et al, 1994) could be conceptualized as measuring two types of craving experiences: reward craving and relief craving (Glöckner-Rist, Lémenager, Mann & PREDICT Study Research Group, 2013). Further, in a recently detoxified sample of individuals with AUD the authors found that both types of craving experiences, as measured by the Temptation scale, were significantly associated with perceived stress.…”

Section: Introductionmentioning

confidence: 99%

Examining temptation to drink from an existential perspective: Associations among temptation, purpose in life, and drinking outcomes.

Roos¹,

Kirouac²,

Pearson³

et al. 2015

Psychology of Addictive Behaviors

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Temptation to drink, defined as the degree to which one feels compelled to drink in the presence of internal or external alcohol-related cues, has been shown to predict alcohol treatment outcomes among individuals with alcohol use disorders (AUDs). Research examining temptation to drink from an existential perspective is lacking and little is known about how existential issues such as purpose in life (PIL) relate to temptation to drink, which is surprising given the role of existential issues in many treatments and mutual help approaches for AUDs. The current study examined the longitudinal associations among temptation to drink, PIL, and drinking outcomes using data from Project MATCH (N = 1726). Parallel process latent growth curve analyses indicated that PIL and temptation to drink were significantly associated across time, such that higher initial levels of PIL and increases in PIL over time were associated with lower initial levels of temptation to drink and decreases in temptation to drink over time. Higher initial levels of temptation to drink, lower initial levels of PIL, increases in temptation to drink, and decreases in PIL were significantly associated with greater intensity and frequency of drinking and greater drinking-related consequences at the 15-month follow-up. Accordingly, temptation to drink and PIL may be important constructs for clinicians to consider throughout the course of treatment. Future studies should examine if and how various kinds of treatments for AUDs are associated with increases in PIL, and whether these increases are related to decreased temptation to drink and reduced drinking.

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Reward and relief craving tendencies in patients with alcohol use disorders: Results from the PREDICT study

Cited by 51 publications

References 32 publications

Psychiatric, Demographic, and Brain Morphological Predictors of Relapse After Treatment for an Alcohol Use Disorder

Psychiatric, Demographic, and Brain Morphological Predictors of Relapse After Treatment for an Alcohol Use Disorder

Reward and relief dimensions of temptation to drink: construct validity and role in predicting differential benefit from acamprosate and naltrexone

Examining temptation to drink from an existential perspective: Associations among temptation, purpose in life, and drinking outcomes.

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