Revolutionizing biodegradable metals

Yun, Yeoheung; Dong, Zhongyun; Lee, Namheon; Liu, Yijun; Xue, Dingchuan; Guo, Xiaoxi; Kuhlmann, Julia; Doepke, Amos; Halsall, H. Brian; Heineman, William R.; Sundaramurthy, Surya; Schulz, Mark J.; Yin, Zhijun; Shanov, Vesselin; Hurd, Douglas; Nagy, Péter B.; Li, Weifeng; Fox, Curtis A.

doi:10.1016/s1369-7021(09)70273-1

Cited by 234 publications

(129 citation statements)

References 78 publications

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“…The idealized biological efficacy of an implant would be where the implant material gets totally amalgamated with the newly formed osseous tissue and thereafter it disintegrates into the blood stream without causing damage to the vital organs or losing its functionality. 27 The main aim of the present study was to check the stability and in vivo cellular response to Mg alloyed with Zr, Sr and Ca and to evaluate the influence of these divalent cations on the in vivo compatibility of these alloys. We hypothesize that inclusion of Sr in Mg alloys can change their surface properties and can control the potential of these alloys to interact with the osteoblast cells.…”

Section: Introductionmentioning

confidence: 99%

Zirconium, calcium, and strontium contents in magnesium based biodegradable alloys modulate the efficiency of implant-induced osseointegration

Mushahary

Sravanthi²,

Li³

et al. 2013

IJN

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Development of new biodegradable implants and devices is necessary to meet the increasing needs of regenerative orthopedic procedures. An important consideration while formulating new implant materials is that they should physicochemically and biologically mimic bone-like properties. In earlier studies, we have developed and characterized magnesium based biodegradable alloys, in particular magnesium-zirconium (Mg-Zr) alloys. Here we have reported the biological properties of four Mg-Zr alloys containing different quantities of strontium or calcium. The alloys were implanted in small cavities made in femur bones of New Zealand White rabbits, and the quantitative and qualitative assessments of newly induced bone tissue were carried out. A total of 30 experimental animals, three for each implant type, were studied, and bone induction was assessed by histological, immunohistochemical and radiological methods; cavities in the femurs with no implants and observed for the same period of time were kept as controls. Our results showed that Mg-Zr alloys containing appropriate quantities of strontium were more efficient in inducing good quality mineralized bone than other alloys. Our results have been discussed in the context of physicochemical and biological properties of the alloys, and they could be very useful in determining the nature of future generations of biodegradable orthopedic implants.

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Section: Introductionmentioning

confidence: 99%

Zirconium, calcium, and strontium contents in magnesium based biodegradable alloys modulate the efficiency of implant-induced osseointegration

Mushahary

Sravanthi²,

Li³

et al. 2013

IJN

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“…There are various corrosion types during the Mg degradation process, including uniform corrosion [54,55], localized corrosion [54,55], flow-induced corrosion [55], erosion corrosion [56], galvanic corrosion [57], stress corrosion [58], atmospheric corrosion, hydrogen cracking [59] and intergranular corrosion [60]. It is worth noting that localized corrosion is always a source of stent fracture.…”

Section: In Vitro Immersion Testmentioning

confidence: 99%

Surface Modification of Magnesium and its Alloys Using Anodization for Orthopedic Implant Application

Mousa¹,

Park²,

Kim³

2017

Magnesium Alloys

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Magnesium (Mg) as a biodegradable implant brings a revolution in medical field application, especially in bone implant and stent application. Biodegradability of Mg has attracted attentions of researchers to avoid secondary surgery to remove the implant materials after healing process. Various advantages of Mg make it suitable for medical application such as density, good mechanical properties and biodegradation. However, Mg biodegradability must be controlled to meet tissue-healing period of time because of the high degradation in a physiological environment. Fast corrosion and high alkalinity due to hydrogen release induce tissue inflammation, which limits its clinical applications. Many techniques are applied to the Mg surface to improve surface biocompatibility and control its biodegradability. This chapter focuses on anodization of Mg and its alloys to improve corrosion resistance and biocompatibility for orthopedic application. Mg coating with thin film apatite could enhance the biocompatibility and increase osseointegration formation in the bone fracture side. Evaluation of the required anodized film discussed in the chapter such as chemical composition, biodegradability and biocompatibility.

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“…However, only Mg-based BDS have run to clinical tests. In the physiological environment, Mg or its alloys corrodes into soluble Mg(OH) 2 , MgCl 2 and H 2 at a fast corrosion rate [56]. The released Mg ions together with the formation of hydrogen bubbles will lead to the higher local pH values which may cause chronic inflammatory reactions and blood disorder [57,58].…”

Section: Biodegradable Stentsmentioning

confidence: 99%

Current status of research and application in vascular stents

Yang

Maitz

2013

Chin. Sci. Bull.

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Cardiovascular diseases have been the leading cause of death in modern society. Using vascular stents to treat these coronary and peripheral artery diseases has been one of the most effective and rapidly adopted medical interventions. During the twenty-five years' development of vascular stents, revolutionary cardiovascular stents like drug eluting stents and endothelial progenitor cells capture stents have emerged. In this review, the evolution of vascular stents is summarized, aiming to provide a glimpse into the future of vascular stents. Advanced designs, focusing on the investigations of new substrates, new platforms, new drugs and new biomolecules are currently under evaluation with promising clinical studies. The concept of "time sequence functional stent" has been raised in this paper. It presents anti-proliferative properties in the first phase after implantation and subsequently support endothelialization. It also shows long-term inertness without release of toxic ions or toxic degradation products. The success of this concept is briefly presented with a clinical study in this model stents.

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Revolutionizing biodegradable metals

Cited by 234 publications

References 78 publications

Zirconium, calcium, and strontium contents in magnesium based biodegradable alloys modulate the efficiency of implant-induced osseointegration

Zirconium, calcium, and strontium contents in magnesium based biodegradable alloys modulate the efficiency of implant-induced osseointegration

Surface Modification of Magnesium and its Alloys Using Anodization for Orthopedic Implant Application

Current status of research and application in vascular stents

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