Revisiting the Goldilocks Phenomenon: Folate and Colorectal Cancer Risk

Mason, Joel B.; Kim, Susan J.

doi:10.1038/ajg.2010.189

Cited by 5 publications

(5 citation statements)

References 29 publications

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“…Cole et al suggested that only physiological levels of folic acid play a protective role, whereas intense supplementation may lead to progression of small preexisting adenomas. Additionally, supplementation of folic acid in high dosages (1,000 μg/day) appears to increase the risk of neoplasms, especially in the elderly population [26]. …”

Section: Dietary Factorsmentioning

confidence: 99%

Lifestyle Modifications and Colorectal Cancer

Durko

Małecka‐Panas

2014

Curr Colorectal Cancer Rep

113

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Many studies suggest that Western lifestyle and dietary factors may be responsible for the high incidence of colorectal cancer in industrialized countries. Consumption of high amounts of red and processed meat and low intake of fiber and multiple protective phytochemicals found in fruits, vegetables, and whole grains might be responsible for the high incidence of this neoplasm in the Western world. Additionally, obesity, lack of physical activity, tobacco and alcohol use, sleep deprivation, and other factors have been proven to further increase the risk of colorectal cancer. Identifying and understanding the mechanisms through which they impact colon carcinogenesis is needed for the introduction of protective lifestyle recommendations.

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Section: Dietary Factorsmentioning

confidence: 99%

Lifestyle Modifications and Colorectal Cancer

Durko

Małecka‐Panas

2014

Curr Colorectal Cancer Rep

113

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“…As reviewed by Mason et al , 40 there was an increase in colorectal cancer incidence in both the U.S. and Canada that coincided with mandatory folic acid fortification in the mid 90’s. It has been postulated that the increased folate levels seen at this time may have allowed previously existing, however otherwise clinically indolent, tumors to proliferate.…”

Section: Folate and Prostate Carcinogenesismentioning

confidence: 98%

Opposing Roles of Folate in Prostate Cancer

Rycyna

Bacich

O’Keefe

2013

Urology

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“…8 There are several conflicting studies regarding the relationship between folic acid and cancer risk. [9][10][11][12] Some reports have shed light on the protective effect of folic acid. Recent trials have suggested that taking folic acid, particularly during the preconception period and pregnancy, can prevent certain types of cancer, such as acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML), by reducing the risk of chromosomal abnormalities.…”

Section: Introductionmentioning

confidence: 99%

Folic acid: friend or foe in cancer therapy

Thabet,

Alessa,

Al-Smadi

et al. 2024

J Int Med Res

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Folic acid plays a crucial role in diverse biological processes, notably cell maturation and proliferation. Here, we performed a literature review using articles listed in electronic databases, such as PubMed, Scopus, MEDLINE, and Google Scholar. In this review article, we describe contradictory data regarding the role of folic acid in cancer development and progression. While some studies have confirmed its beneficial effects in diminishing the risk of various cancers, others have reported a potential carcinogenic effect. The current narrative review elucidates these conflicting data by highlighting the possible molecular mechanisms explaining each point of view. Further multicenter molecular and genetic studies, in addition to human randomized clinical trials, are necessary to provide a more comprehensive understanding of the relationship between folic acid and cancer.

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Revisiting the Goldilocks Phenomenon: Folate and Colorectal Cancer Risk

Cited by 5 publications

References 29 publications

Lifestyle Modifications and Colorectal Cancer

Lifestyle Modifications and Colorectal Cancer

Opposing Roles of Folate in Prostate Cancer

Folic acid: friend or foe in cancer therapy

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