Lifestyle Modifications and Colorectal Cancer

Abstract

Many studies suggest that Western lifestyle and dietary factors may be responsible for the high incidence of colorectal cancer in industrialized countries. Consumption of high amounts of red and processed meat and low intake of fiber and multiple protective phytochemicals found in fruits, vegetables, and whole grains might be responsible for the high incidence of this neoplasm in the Western world. Additionally, obesity, lack of physical activity, tobacco and alcohol use, sleep deprivation, and other factors have been proven to further increase the risk of colorectal cancer. Identifying and understanding the mechanisms through which they impact colon carcinogenesis is needed for the introduction of protective lifestyle recommendations.

Influence of miRNA-106b and miRNA-135a on butyrate-regulated expression of p21 and Cyclin D2 in human colon adenoma cells

“…Colon cancer is mainly a lifestyle-associated disease, which is predominantly influenced by nutrition (Durko and Malecka-Panas 2014). The consumption of dietary fiber is associated with a lower risk of CRC development (Aune et al 2011;Bingham et al 2003).…”

“…In contrast, most cases of CRC are sporadic (75 %) and without identifiable genetic etiology. This form of CRC is mainly influenced by lifestyle factors such as high red meat consumption, high-fat low-fiber diet, alcohol and tobacco consumption, obesity as well as lack of physical activity (Durko and Malecka-Panas 2014). Sporadic CRC is also caused by acquired sequential genetic and/or epigenetic alterations in tumor suppressing as well as promoting genes known as the adenoma-carcinoma sequence described by Fearon and Vogelstein (1990).…”

Taurocholic acid metabolism by gut microbes and colon cancer

“…Physical activity, smoking status, alcohol, types and quantity of dietary fiber, micronutrient intake, and diets high in animal protein and saturated fat all appear to play a role in the disease. 3 The goal of much observational and mechanistic work spanning many decades is to establish how we can alter our environment so as to lower the risk for CRC. Intriguingly, each of these factors also alters the gut microbiome.…”

Cancer prevention awareness among young adult Polish females on the basis of the assessment of knowledge and health behaviours

“…Deficit of behaviour/knowledge the risk of cancer [17][18][19][20][21]. Biopositive compounds include a wide group of polyphenols, polyunsaturated fatty acids, carotenoids, vitamins (D, E, C, folic acid), minerals (Se, Zn, Ca), and dietary fibre [19,21].…”

“…Biopositive compounds include a wide group of polyphenols, polyunsaturated fatty acids, carotenoids, vitamins (D, E, C, folic acid), minerals (Se, Zn, Ca), and dietary fibre [19,21]. Diets rich in these elements consist mainly of vegetables, fruit, and cereals [21].…”