Revisiting nature: a review of iridoids as a potential antileishmanial class

Gonçalves, Guilherme Arraché; Eifler‐Lima, Vera Lucia; Poser, Gilsane Lino von

doi:10.1007/s11101-021-09750-8

Cited by 9 publications

(3 citation statements)

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“…The tiliroside ( 6) is a ubiquitous flavonoid under this genus, and it is a compound with probed actions in different biological research (Luhata and Luhata, 2017;Grochowski et al, 2018). Regarding the sweroside (5) belonging to the iridoids, they are not common in the genus but are also metabolites with interesting results in investigations that trying to deal with biological activities (Hussain et al, 2019;Arraché-Gonçalves et al, 2021). The results here exposed shown that all the metabolites found in these two Ecuadorian medicinal plants, are considered under the chemotaxonomy of both genus, and they could be responsible for the medicinal properties attributed by the people to these species.…”

Section: Resultsmentioning

confidence: 99%

Chemical constituents of two Ecuadorian medicinal plants, Tagetes terniflora Kunth and Croton rivinifolius Kunth

Suárez

Morocho

Luna

et al. 2021

Revista De La Facultad De Farmacia

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Phytochemical study of two medicinal plants from Ecuador, Tagetes terniflora Kunth, and Croton rivinifolius Kunth, led to the isolation and characterization of the major constituents present in the organic extracts obtained from these plants: 5-(4-acetoxy-1-butynil)-2,2’-bi-thiophene (1), 5-methyl-2,2’:5’,2”- terthiophene (2), patuletin (3) from Tagetes terniflora, and isocorydine (4), sweroside (5), tiliroside (6) from Croton rivinifolius. The structures of these compounds were established by spectroscopic analysis including two-dimensional NMR methods, MS, and comparison with published spectral data. They are recognized as secondary metabolites that represent the chemotaxonomy of Tagetes and Croton genera and could be responsible for the recognized medicinal properties attributed to these species. This paper deals with the first report that shows the presence of these compounds in these plants.

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Section: Resultsmentioning

confidence: 99%

Chemical constituents of two Ecuadorian medicinal plants, Tagetes terniflora Kunth and Croton rivinifolius Kunth

Suárez

Morocho

Luna

et al. 2021

Revista De La Facultad De Farmacia

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“…Leishmania-host interactions are considered to be excellent models of virulence factors, the efficiency of survival and transmission strategies over the life cycle, the ability to interact with the physiology and complex molecular mechanisms of the host cell, the modification of the cellular environment, the establishment of different niches, and modulation with the histopathological and immune responses of different hosts [20,38,63,64]. The uptake of the promastigotes by the phagocytes involves a number of different strategies that enable the parasite to interfere with the sequential protective actions of the two principal host immunological mechanisms [20].…”

Section: Host Leishmania Interactions Through Extracellular Productsmentioning

confidence: 99%

Leishmania 360°: Guidelines for Exosomal Research

et al. 2021

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Leishmania parasites are a group of kinetoplastid pathogens that cause a variety of clinical disorders while maintaining cell communication by secreting extracellular vesicles. Emerging technologies have been adapted for the study of Leishmania-host cell interactions, to enable the broad-scale analysis of the extracellular vesicles of this parasite. Leishmania extracellular vesicles (LEVs) are spheroidal nanoparticles of polydispersed suspensions surrounded by a layer of lipid membrane. Although LEVs have attracted increasing attention from researchers, many aspects of their biology remain unclear, including their bioavailability and function in the complex molecular mechanisms of pathogenesis. Given the importance of LEVs in the parasite-host interaction, and in the parasite-parasite relationships that have emerged during the evolutionary history of these organisms, the present review provides an overview of the available data on Leishmania, and formulates guidelines for LEV research. We conclude by reporting direct methods for the isolation of specific LEVs from the culture supernatant of the promastigotes and amastigotes that are suitable for a range of different downstream applications, which increases the compatibility and reproducibility of the approach for the establishment of optimal and comparable isolation conditions and the complete characterization of the LEV, as well as the critical immunomodulatory events triggered by this important group of parasites.

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“…В ряде исследований у экстрактов, полученных из растений рода марьянник, выявлена антиоксидантная, антимикробная [10], цитотоксическая [11] активность. В последние годы биологическая активность индивидуальных веществ, выделенных из видов рода марьянник, изучается с целью создания потенциальных лекарственных средств для лечения трипаносомоза [12], лейшманиоза [13,14], а также оказывающих противовоспалительное действие [15].…”

Section: Introductionunclassified

Biological Activity study of the <i>Melampyrum sylvaticum</i> Extract

Galishevskaya,

Polyakova,

Bombela

et al. 2023

Razrabotka i registraciâ lekarstvennyh sredstv

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Introduction. Among wild plants that have an effect on the nervous system, species of the genus Melampyrum L. are distinguished, in particular, Melampyrum sylvaticum L. Extracts from the aerial part of the plant have long been used in folk medicine as sedatives and anticonvulsants. Currently, a number of studies are being carried out to confirm the possibility of using wildflower and drugs based on it in scientific medicine, as well as to obtain a drug with low toxicity, complex sedative and anticonvulsant activity, which will expand the arsenal of drugs used to treat diseases of the nervous system.Aim. To investigate the in vivo acute toxicity, anticonvulsant and sedative activity of a dry alcohol extract from the aerial part of Melampyrum sylvaticum.Materials and methods. The extract was obtained by extracting substances from the aerial part of Melampyrum sylvaticum with 50 % ethanol, by the method of repercolation with an equal loading of raw materials, followed by evaporation to a dry residue. The study of pharmacological properties was carried out on nonlinear white mice of both sexes weighing 17–25 g. Acute toxicity of the extract was determined by oral administration in doses up to 5000 mg/kg. Anticonvulsant activity was evaluated in the corazole convulsion test, sedative activity was evaluated in the open field test.Results and discussion. When determining the acute toxicity of a dry alcoholic extract from the aerial part of Melampyrum sylvaticum, there was no lethality in the experimental group of animals. LD50 could not be determined. In the corazol convulsion test, it was shown that oral administration of the extract at a dose of 100 mg/kg does not affect the latent period of convulsions, but significantly increases the life expectancy of animals. At a dose of 200 mg/kg, the latent period of seizures and life expectancy significantly increased, and the survival rate of animals was 20 %. When studying sedative activity of the extract from Melampyrum sylvaticum in the open field test, a decrease in vertical activity, a decrease in the number of vertical stands, a decrease in horizontal activity along the periphery and the number of animals entering the center of the area were noted, which indicates a suppression of orienting-exploratory behavior. In the experiment, there was a decrease in the intensity of grooming as an indicator of anxiety for this group of animals. A course of administration of the extract for thirty days led to a decrease in the vertical activity of mice and inhibition of orienting-exploratory behavior.Conclusion. It was found that a dry alcoholic extract from the aerial part of Melampyrum sylvaticum exhibits biological activity in animal experiments, compensating for the effect of corazol, and has a pronounced anticonvulsant and sedative effect. The LD50 of the extract when administered orally was more than 5000 mg/kg.

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Revisiting nature: a review of iridoids as a potential antileishmanial class

Cited by 9 publications

References 94 publications

Chemical constituents of two Ecuadorian medicinal plants, Tagetes terniflora Kunth and Croton rivinifolius Kunth

Chemical constituents of two Ecuadorian medicinal plants, Tagetes terniflora Kunth and Croton rivinifolius Kunth

Leishmania 360°: Guidelines for Exosomal Research

Biological Activity study of the <i>Melampyrum sylvaticum</i> Extract

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