Revisiting Iron Metabolism, Iron Homeostasis and Iron Deficiency Anemia

Saboor, Muhammad; Zehra, Amtuz; Hamali, Hassan A; Mobarki, Abdullah A

doi:10.7754/clin.lab.2020.200742

Cited by 14 publications

(13 citation statements)

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“…O ferro heme possui maior biodisponibilidade, sendo afetado apenas pela quantidade de cálcio ingerida ao mesmo tempo e da quantidade de carne ingerida. Em contrapartida, mesmo sendo menos biodisponível, o ferro não heme é o mais consumido na alimentação e alguns fatores podem afetar a sua biodisponibilidade como: fitatos, taninos, oxalatos e cálcio, e outros atuam como facilitadores, como: ácido cítrico, ácido ascórbico e proteína animal (Saboor et al, 2021).…”

Section: ▪ Ferrounclassified

Dietas vegetarianas na nutrição de mulheres grávidas

Rodrigues

Azevedo

Correia-Santos

2022

RSD

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As dietas vegetarianas aumentaram em todo o mundo nas últimas décadas, e estas estão consistentemente associadas a melhores resultados de saúde, contudo, ainda não está claro se uma dieta vegetariana é apropriada para a gravidez. A dieta materna não está apenas correlacionada com a saúde do feto, mas também parece relevante para a da mãe. Essa revisão tem como objetivo apresentar uma visão geral dos potenciais efeitos do vegetarianismo durante a gestação. O estudo foi realizado por revisão de literatura. Foram utilizados artigos científicos, livros e sites licenciados publicados nos último 10 anos, em português e inglês. Embora com o uso das dietas vegetarianas corram o risco de deficiências nutricionais, como proteínas, ferro, cálcio, ômega-3 e vitamina B12, as evidências disponíveis mostram que dietas vegetarianas bem planejadas podem ser consideradas seguras durante a gravidez, mas eles exigem uma forte consciência para uma ingestão equilibrada de nutrientes essenciais, sendo necessário, então, uma intervenção nutricional pré-gestacional e gestacional para evitar problemas com relação a nutrição materna e o consequente crescimento fetal prejudicado

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Section: ▪ Ferrounclassified

Dietas vegetarianas na nutrição de mulheres grávidas

Rodrigues

Azevedo

Correia-Santos

2022

RSD

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“…Central to understanding perinatal iron deficiency is the realization that it is a spectrum, not a dichotomous variable of iron deficiency vs iron sufficiency. 3,4 Table 1 groups the spectrum of perinatal iron deficiency into three recognizable entities. These can be considered as early, mid-, and late manifestations of iron Biochemical iron deficiency exists when metrics indicate that the iron supply is low.…”

Section: Preamblementioning

confidence: 99%

Iron Deficiency in Newborn Infants: Global Rewards for Recognizing and Treating This Silent Malady

Christensen¹,

Bahr²

2022

Newborn

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Iron deficiency can exist at birth. Even if iron is sufficient at birth, deficiency can develop during the neonatal period, or during infancy, or during childhood. Iron deficiency can exist despite a normal hematocrit and a normal blood hemoglobin concentration, because anemia is a very late manifestation of iron deficiency. It is likely that adverse neurodevelopmental consequences occur during perinatal biochemical iron deficiency, despite a normal hematocrit and hemoglobin. Consequently, measuring those parameters is a very insensitive method for perinatal iron deficiency screening. This review focuses on potentially better practices for diagnosing perinatal iron deficiency, including recent advances in understanding the pathogenesis of this condition, and also on practical means of treatment, and on global rewards of so doing.

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“…This is due in particular to the different electronic and redox properties of these ions. Iron ions occur in biological systems mainly in the oxidation states 2+ (d 6 configuration) and 3+ (d 5 ), which are stabilized by different ligands according to Pearson's hard and soft (Lewis) acids and bases (HSAB) concept [12]. This concept deems species that are small, highly charged and weakly polarizable as "hard" and species that are large, lowly charged and highly polarizable as "soft".…”

Section: Coordination Chemistry Of Iron and Coppermentioning

confidence: 99%

“…The essential elements iron and copper are needed for the proper function of redox processes in every organism, and their metabolism is strictly regulated [1][2][3][4]. Deficiencies of iron and copper are common and are reviewed elsewhere [5,6]. However, the excess of iron and copper is dangerous, as these elements as free ions catalyze the formation of reactive oxygen species (ROS), which may damage the organism in an even fatal way if untreated.…”

Section: Introductionmentioning

confidence: 99%

Chelators for Treatment of Iron and Copper Overload: Shift from Low-Molecular-Weight Compounds to Polymers

et al. 2021

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Iron and copper are essential micronutrients needed for the proper function of every cell. However, in excessive amounts, these elements are toxic, as they may cause oxidative stress, resulting in damage to the liver and other organs. This may happen due to poisoning, as a side effect of thalassemia infusion therapy or due to hereditary diseases hemochromatosis or Wilson’s disease. The current golden standard of therapy of iron and copper overload is the use of low-molecular-weight chelators of these elements. However, these agents suffer from severe side effects, are often expensive and possess unfavorable pharmacokinetics, thus limiting the usability of such therapy. The emerging concepts are polymer-supported iron- and copper-chelating therapeutics, either for parenteral or oral use, which shows vivid potential to keep the therapeutic efficacy of low-molecular-weight agents, while avoiding their drawbacks, especially their side effects. Critical evaluation of this new perspective polymer approach is the purpose of this review article.

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Revisiting Iron Metabolism, Iron Homeostasis and Iron Deficiency Anemia

Cited by 14 publications

References 0 publications

Dietas vegetarianas na nutrição de mulheres grávidas

Dietas vegetarianas na nutrição de mulheres grávidas

Iron Deficiency in Newborn Infants: Global Rewards for Recognizing and Treating This Silent Malady

Chelators for Treatment of Iron and Copper Overload: Shift from Low-Molecular-Weight Compounds to Polymers

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