Revisiting Ipriflavone: a Potential Isoflavone for the Management of Postmenopausal Osteoporosis

John, Anish; Vadakkepushpakath, Anoop Narayanan; Konkodi, Kiran

doi:10.1007/s43450-021-00192-z

Cited by 1 publication

(3 citation statements)

References 42 publications

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“…IPRI improves bone quality and protects bone tissue through direct and indirect actions that finally promotes MSCs osteogenesis. The anti-osteoporotic activity of IPRI is achieved through its ability to trigger osteoblast proliferation and maintain bone density while inhibiting bone resorption and retarding the osteoclasts multiplication [21,22]. An earlier study conducted by Yamazaki, Shino [89] reported the ability of IPRI to suppress bone resorption induced by the glucocorticoid prednisolone.…”

Section: Discussionmentioning

confidence: 99%

“…Solubility is an essential rate-limiting criterion for orally delivered medicines to achieve their required concentration in systemic circulation for pharmacological response [92]. Therefore, IPRI's poor aqueous solubility limits its bioavailability and pharmacological actions [22]. Moreover, the use of IPRI is associated with various side effects such as headache, drowsiness, dizziness, depression, rash, and tachycardia [93].…”

Section: Discussionmentioning

confidence: 99%

“…Regarding the beneficial effects of date pits extract (DPE), the present study was accomplished to appraise the possible anti-osteoporotic effect of two different doses of DPE against dexamethasone (DEXA)-induced osteoporosis in male rats through assessing the Wnt signaling pathway, osteoblasts', and osteoclasts' differentiation mediators and markers. Furthermore, ipriflavone (IPRI) is a synthetic isoflavone derivative and has commonly been used in the prevention and treatment of osteoporosis [21,22]. In this study, we used it as a reference drug.…”

Section: Introductionmentioning

confidence: 99%

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Phoenix dactilyfera L. Pits Extract Restored Bone Homeostasis in Glucocorticoid-Induced Osteoporotic Animal Model through the Antioxidant Effect and Wnt5a Non-Canonical Signaling

et al. 2022

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Oxidative stress associated with long-term glucocorticoids administration is a route through which secondary osteoporosis can be developed. The therapeutic potential of Phoenix dactilyfera L. pits is offered by their balanced, valuable and diverse phytochemical composition providing protective potential against oxidative reactions, making it a good candidate to treat glucocorticoid-induced osteoporosis (GIO). This study evaluates the possible anti-osteoporotic effect of date pit extract (DPE) against dexamethasone (DEXA)-induced osteoporosis. Male rats were allocated into three control groups, which received saline, low and high doses of DPE (150 and 300 mg/kg/day), respectively. Osteoporosis-induced groups that received DEXA (1 mg/kg/day) were divided into DEXA only, DPE (2 doses) + DEXA, and ipriflavone + DEXA. Femoral bone minerals density and bone mineral content, bone oxidative stress markers, Wnt signaling, osteoblast and osteoclast differentiation markers, and femur histopathology were evaluated. DPE defeated the oxidative stress, resulting in ameliorative changes in Wnt signaling. DPE significantly reduced the adipogenicity and abolished the osteoclastogenic markers (RANKL/OPG ratio, ACP, TRAP) while enhancing the osteogenic differentiation markers (Runx2, Osx, COL1A1, OCN). In Conclusion DPE restored the balanced proliferation and differentiation of osteoclasts and osteoblasts precursors. DPE can be considered a promising remedy for GIO, especially at a low dose that had more potency.

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Section: Discussionmentioning

confidence: 99%