Revisiting Double Kidney Transplantation: Two Kidneys Provide Better Graft Survival Than One

Cruzado, Josep M.; Fernández, Luis Miguel González; Riera, L.; Bestard, Oriol; Carrera, Marta; Torras, Juan; Vernet, Salvador Gil; Melilli, Edoardo; Ngango, Liliane; Grinyó, Josep M.

doi:10.1016/j.transproceed.2011.05.018

Cited by 22 publications

(19 citation statements)

References 7 publications

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“…Our DGF rate in DKT (12.8%) is lower than that reported in most of other studies Ref. 38,39,(39)(40)(41)(42)(43)(44)52,54,56,57,(60)(61)(62)64,65,74,75,78), these results being probably related to the use of anti-thymocyte globulin for immunosuppressive therapy induction in most of DKT (71.8%) in our centre. However, mean values of serum creatinine and GFR seem to be similar at 12 months (respectively 148.9 vs 119-159 lmol/l [38,41,43,44,52,54,[56][57][58]61,62,74,75,77,78] and 46.7 vs 42-55 ml/min, Ref.…”

Section: Discussioncontrasting

confidence: 78%

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Safety of dual kidney transplantation compared to single kidney transplantation from expanded criteria donors: a single center cohort study of 39 recipients

Mendel¹,

Albano²,

Bentellis³

et al. 2018

Transpl Int

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Our objective was to compare the outcomes of dual kidney transplanataion (DKT) to single kidney transplantation (SKT) performed with grafts from expanded criteria donors (ECD) in recipients ≥65 years, focusing on surgical complications. All kidney transplantations (KT) performed between 2006 and 2014 in our institution were analysed. DKT was indicated according to the criteria of the French national Agence de la Biomedecine. Thirty-nine DKT and 155 SKT were included, with a median follow-up of 36 and 26.5 months, respectively. The rate of early surgical revisions was not significantly higher after DKT (23.1% vs 15.5% (P = 0.2593)) but more venous graft thromboses (12.8% vs 3.2% (P = 0.02)) were reported. The glomerular filtration rate (GFR) 24 months after KT was significantly higher after DKT (45.0 ± 16.3 vs 39.8 ± 13.8 ml/min/1.73m ; P = 0.04) and allowed shorter waiting time without a significant increased risk of surgical revision, excepted for venous graft thrombosis, more frequent after DKT. Graft survivals were not significantly different and GFR was higher after DKT. DKT seems to remain an appropriate strategy to address the growing graft shortage in elderly patients.

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Section: Discussioncontrasting

confidence: 78%

“…However, mean values of serum creatinine and GFR seem to be similar at 12 months (respectively 148.9 vs 119-159 lmol/l [38,41,43,44,52,54,[56][57][58]61,62,74,75,77,78] and 46.7 vs 42-55 ml/min, Ref. 38,40,41,43,52,53,55,57,62,64).…”

Section: Discussionmentioning

confidence: 92%

Safety of dual kidney transplantation compared to single kidney transplantation from expanded criteria donors: a single center cohort study of 39 recipients

Mendel¹,

Albano²,

Bentellis³

et al. 2018

Transpl Int

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“…We also had 2 patients with Remuzzi score of 8, and 1 with a score of 9, in whom posttransplant function was lost during the early posttransplant period, as this scoring system predicts. Despite Remuzzi's approach for ECD kidney transplants was proved accurate in many prospective and retrospective studies, [14][15][16][31][32][33] we cannot confirm this, probably because of the small number of patients in our study.…”

Section: Discussionmentioning

confidence: 62%

Dual Kidney Transplant: A Single-Center Experience and Review of the Literature

Balaz

Rokošný²,

Wohlfahrt³

et al. 2013

Exp Clin Transplant

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Objectives: Adult dual kidney transplant is a strategy to overcome the imbalance between limited nephron mass supplied from an older donor and a recipient with a metabolic request. Materials and Methods: In our report, we review the literature and present our single-center experience. From June 2007 until July 2012, nine hundred twenty-eight single and seventeen dual kidney transplants from deceased donors were performed. Results: The average donor was 71.5 ± 3.6 years of age with an average serum creatinine, creatinine clearance, and an average number of sclerotic glomeruli, 106.1 ± 44.2 µmol/L, 0.97 ± 0.37 mL/s, and 22.4 ± 14.2. Immediate graft function and acute rejection episodes were observed in 75% and 6% of patients. The overall patient survival rates at 1 and 2 years after transplant were 93%. The overall graft survival rates at 1 and 2 years were 88%. Conclusions: Previous studies and our single-center experience suggest that the dual transplant procedure may help improve results of kidney transplants from expanded criteria donors and extend the donor pool by using kidneys that would be discarded otherwise.

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“…Another interesting strategy raising ethical questions in a situation of organ scarcity, is allocating a pair of ECD kidneys in younger recipients. In middle‐aged and older recipients, results of this type of transplantation have proven to be successful .…”

Section: Discussionmentioning

confidence: 99%

Increased risk of graft failure and mortality in Dutch recipients receiving an expanded criteria donor kidney transplant

et al. 2016

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SUMMARY. RDs showed a similar pattern. In diabetics, the risks for graft failure and death were higher than in the nondiabetics. ECD kidney grafts have a poorer prognosis than non-ECD grafts, especially in younger recipients (<60 years), and diabetic recipients. Further studies and ethical discussions should reveal whether ECD kidneys should preferentially be allocated to specific subgroups, such as elderly and nondiabetic individuals.

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Revisiting Double Kidney Transplantation: Two Kidneys Provide Better Graft Survival Than One

Cited by 22 publications

References 7 publications

Safety of dual kidney transplantation compared to single kidney transplantation from expanded criteria donors: a single center cohort study of 39 recipients

Safety of dual kidney transplantation compared to single kidney transplantation from expanded criteria donors: a single center cohort study of 39 recipients

Dual Kidney Transplant: A Single-Center Experience and Review of the Literature

Increased risk of graft failure and mortality in Dutch recipients receiving an expanded criteria donor kidney transplant

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