Revisitation of imaging features of skull base chondrosarcoma in comparison to chordoma

Hasegawa, Hirotaka; Shin, Masahiro; Niwa, Ryoko; Koizumi, Satoshi; Yoshimoto, Shoko; Shono, Naoyuki; Shinya, Yuki; Takami, Hirokazu; Tanaka, Shota; Umekawa, Motoyuki; Amemiya, Shonan; Kin, Taichi; Saito, Nobuhito

doi:10.1007/s11060-022-04097-2

Cited by 8 publications

(10 citation statements)

References 26 publications

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“…Radiologically chondrosarcoma as well as chordoma demonstrate a T1 hypointensity with T2 hyperintensitiy and variable contrast enhancement, chordoma typically originate from the midline 7. A recent Japanese study showed that apparent diffusion coefficient value ≥1750×10 −6 mm 2 /s were predictive for chondrosarcoma 8. In our patient, the mass exhibited a high signal intensity on T2 and a hypointensitiy on T1 with little contrast enhancement and restricted diffusion.…”

Section: Investigationsmentioning

confidence: 46%

Chondrosarcoma of the petrous apex with nerve abducens involvement in a woman with pre-existing contralateral amblyopia

Meier,

Rajan

2023

BMJ Case Rep

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We report about a case of a woman in her 50s with a chondrosarcoma of the petrous apex. She has a strabism due to a right-sided amblyopia since childhood and noticed a slowly progressive squint angle in the last months. Her general practitioner (GP) referred her to an ophthalmologist who diagnosed a left abducens paresis and initiated an MRI demonstrating a mass in the left petrous apex. A transnasal endoscopic transsphenoidal biopsy revealed a grade I chondrosarcoma. The patient underwent an endoscopic transsphenoidal anterior petrosectomy approach with complete removal of the tumour. After surgery the squint angle gradually improved to previous levels, so that the patient was able to resume her work. This report demonstrates that even slight changes of a squint angle without diplopia, in this case because of pre-existing amblyopia, could be a hallmark of an intracranial process.

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Section: Investigationsmentioning

confidence: 46%

Chondrosarcoma of the petrous apex with nerve abducens involvement in a woman with pre-existing contralateral amblyopia

Meier,

Rajan

2023

BMJ Case Rep

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“…Furthermore whereas VS show intense GBCA enhancement 47 , enhancement in chordoma and chondrosarcoma is often heterogenous, with a recognised quarter of such tumours demonstrating no or only mild post GBCA enhancement 48 – 50 . The pattern of contrast enhancement can be related to the pathological features of these tumours, with chordoma displaying organized lobules of mucinous and gelatinous contents and chondrosarcoma displaying heterogeneous or arabesque like enhancement due to the presence of fibrovascular bundles surrounding cartilaginous nodules 49 , 50 .…”

Section: Discussionmentioning

confidence: 99%

Low-dose GBCA administration for brain tumour dynamic contrast enhanced MRI: a feasibility study

Lewis,

Li,

Waqar

et al. 2024

Sci Rep

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A key limitation of current dynamic contrast enhanced (DCE) MRI techniques is the requirement for full-dose gadolinium-based contrast agent (GBCA) administration. The purpose of this feasibility study was to develop and assess a new low GBCA dose protocol for deriving high-spatial resolution kinetic parameters from brain DCE-MRI. Nineteen patients with intracranial skull base tumours were prospectively imaged at 1.5 T using a single-injection, fixed-volume low GBCA dose, dual temporal resolution interleaved DCE-MRI acquisition. The accuracy of kinetic parameters (ve, Ktrans, vp) derived using this new low GBCA dose technique was evaluated through both Monte-Carlo simulations (mean percent deviation, PD, of measured from true values) and an in vivo study incorporating comparison with a conventional full-dose GBCA protocol and correlation with histopathological data. The mean PD of data from the interleaved high-temporal-high-spatial resolution approach outperformed use of high-spatial, low temporal resolution datasets alone (p < 0.0001, t-test). Kinetic parameters derived using the low-dose interleaved protocol correlated significantly with parameters derived from a full-dose acquisition (p < 0.001) and demonstrated a significant association with tissue markers of microvessel density (p < 0.05). Our results suggest accurate high-spatial resolution kinetic parameter mapping is feasible with significantly reduced GBCA dose.

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“…Therefore, CS is often found paracentral, in comparison with chordomas that are typically located at the midline. 62,63 Fig. 13 Chordoma.…”

Section: Chondrosarcomamentioning

confidence: 99%

“…On diffusion-weighted images, CS has a higher apparent diffusion coefficient value in comparison with a chordoma, which may help differentiate a chordoma from a chondrosarcoma. 63…”

Section: Chondrosarcomamentioning

confidence: 99%

Imaging of the Craniocervical Junction: A Pictorial Review

Mertens,

Vanhoenacker

2023

Semin Musculoskelet Radiol

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The craniocervical junction (CCJ) is a complex anatomical structure comprising the occiput, the atlas, and the axis. The CCJ plays an important role in maintaining stability, providing protection, and supporting neurovascular structures. The CCJ can be affected by a wide range of congenital variants and traumatic, degenerative, inflammatory, and tumoral pathologies. This pictorial review the normal anatomy of the CCJ and presents the most common anatomical variants and pathologic conditions affecting the CCJ.

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Revisitation of imaging features of skull base chondrosarcoma in comparison to chordoma

Cited by 8 publications

References 26 publications

Chondrosarcoma of the petrous apex with nerve abducens involvement in a woman with pre-existing contralateral amblyopia

Chondrosarcoma of the petrous apex with nerve abducens involvement in a woman with pre-existing contralateral amblyopia

Low-dose GBCA administration for brain tumour dynamic contrast enhanced MRI: a feasibility study

Imaging of the Craniocervical Junction: A Pictorial Review

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