Revision of anterior cruciate ligament reconstruction with patellar tendon allograft and autograft: 2- and 5-year results

Abstract

The functional results with allografts that had not undergone irradiation or chemical sterilization were comparable to those with autografts in ACL revision surgery. Allografts represent a good alternative to autogenous patellar tendons in revision surgery.

Role of bone patellar tendon allograft in revision ACL reconstruction

“…4. We do agree with the authors that the sample size is small and that concurrent procedures on the meniscus would lead to an alteration in the rehabilitation protocol and influence the outcome [1,3].…”

Tendon injury and repair – A perspective on the basic mechanisms of tendon disease and future clinical therapy

“…Still viable resident cells in an autograft will be exposed to a low-nutrient environment may then potentially recruit participation from the extrinsic compartment. This may plausibly explain why autografts do not generally perform superiorly better than allografts [210,[241][242][243]. A promising approach to promote beneficial graft remodeling may be to functionalize the graft with bioactive molecules [244], however such approaches are still in their very early stages and lack clinical evidence of efficacy.…”

The past, present and future in scaffold-based tendon treatments

“…Nonetheless, availability issues and the unavoidable site morbidity that will only partially improve the properties of the originally injured tendon tissue [290][291][292][293] pushed the field towards allogeneic [294][295][296][297][298] alternatives. Clinical data indicated no functional difference between autograft and allograft intervention in ACL repair [299][300][301]; however MRI analysis favoured the autograft, as allograft intervention brought about a less mature neotissue [302]. The use of autografts in ACL reconstruction has been further reinforced with recent data indicating that allografts are almost 6.7 times more likely to fail, when compared to autografts [303].…”