Revised structures for guaianolide α-methylenebutyro-lactones from feverfew

Begley, Michael J.; Hewlett, Martin J.; Knight, David W.

doi:10.1016/0031-9422(89)80150-5

Cited by 49 publications

(21 citation statements)

References 8 publications

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“…Parthenolide, a germacronolide type sesquiterpene, isolated from Tanacetum parthenium by Tournier et al (1999), having also an ␣-methylenebutyrolactone moiety and is known to possess chemical reactivity toward biological nucleophiles, e.g. thiols and amines (Begley et al, 1989).…”

Section: Resultsmentioning

confidence: 99%

Isolation of anti-ulcerogenic sesquiterpene lactones from Centaurea solstitialis L. ssp. solstitialis through bioassay-guided fractionation procedures in rats

Yeşilada

Gürbüz

Bedir

et al. 2004

Journal of Ethnopharmacology

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Section: Resultsmentioning

confidence: 99%

Isolation of anti-ulcerogenic sesquiterpene lactones from Centaurea solstitialis L. ssp. solstitialis through bioassay-guided fractionation procedures in rats

Yeşilada

Gürbüz

Bedir

et al. 2004

Journal of Ethnopharmacology

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“…According to Begley et al (1989), the ␣-methylene-␥-butyrolactone moiety was shown to possess chemical reactivity toward biological nucleophiles, e.g. thiols and amines.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of the anti-ulcerogenic effect of sesquiterpene lactones from Centaurea solstitialis L. ssp. solstitialis by using various in vivo and biochemical techniques

Gürbüz

Yeşilada

2007

Journal of Ethnopharmacology

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“…This function is known to have chemical reactivity toward biological nucleophiles, e.g. thiols and amines (Begley et al 1989). Assays with parthenolide were undertaken to determine whether this lactone contributed to the biological activity of the chloroform extract.…”

Section: Discussionmentioning

confidence: 99%

Effect of the Chloroform Extract of Tanacetum vulgare and one of its Active Principles, Parthenolide, on Experimental Gastric Ulcer in Rats

Tournier¹,

Schinella²,

Balsa³

et al. 1999

Journal of Pharmacy and Pharmacology

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This study examines the anti-ulcerogenic activity of a chloroform extract of Tanacetum vulgare and purified parthenolide, the major sesquiterpene lactone found in the extract. Gastric ulcers induced by oral administration of absolute ethanol to rats were reduced dose-dependently by oral pretreatment of animals with the chloroform extract (2.5-80 mg kg(-1)) or parthenolide (5-40 mg kg(-1)). When administered 30 min before challenge with the alcohol the protection ranged between 34 and 100% for the extract and 27 and 100% for parthenolide. When the products were administered orally 24 h before treatment with ethanol, 40 mg kg(-1) of the extract and of the lactone reduced the mean ulcer index from 4.8+/-0.3 for control animals to 1.4+/-0.2 and 0.5+/-0.1, respectively. The products also prevented alcohol-induced reduction of the number of sulphydryl groups within the gastric mucosa (50.6+/-2.3 microg (mgprotein)(-1) for normal animals compared with 17.7+/-3.0 microg (mg protein)(-1) for alcohol-treated animals). Administration of the extract (80 mg kg(-1)) or parthenolide (40 mg kg(-1)) 24 h before ethanol treatment restored the numbers of mucosal -SH groups to values near those found for normal animals. These results suggest that the products assayed, in particular parthenolide, might find therapeutic application, although further work is required to establish their profit/risk ratio.

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Revised structures for guaianolide α-methylenebutyro-lactones from feverfew

Cited by 49 publications

References 8 publications

Isolation of anti-ulcerogenic sesquiterpene lactones from Centaurea solstitialis L. ssp. solstitialis through bioassay-guided fractionation procedures in rats

Isolation of anti-ulcerogenic sesquiterpene lactones from Centaurea solstitialis L. ssp. solstitialis through bioassay-guided fractionation procedures in rats

Evaluation of the anti-ulcerogenic effect of sesquiterpene lactones from Centaurea solstitialis L. ssp. solstitialis by using various in vivo and biochemical techniques

Effect of the Chloroform Extract of Tanacetum vulgare and one of its Active Principles, Parthenolide, on Experimental Gastric Ulcer in Rats

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