Reviews Basal cell carcinoma – diagnosis

Mackiewicz-Wysocka, Małgorzata; Bowszyc‐Dmochowska, Monika; Strzelecka-Węklar, Daria; Dańczak‐Pazdrowska, Aleksandra; Adamski, Zygmunt

doi:10.5114/wo.2013.35684

Cited by 52 publications

(64 citation statements)

References 30 publications

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“…It has been suggested that this feature stems from peritumoral mucin; from peritumoral oedema or cellular peripheral palisading of BCC cells (accumulation of elongated nuclei orientated in the same axis) . It might be that the OCT finding is associated with all three suggestions; however, in the histological literature, the absence of peripheral palisading and retraction is often described in iBCC subtypes and has generally been associated with more aggressive BCC subtypes . Regardless of the origin of this feature, DPB in OCT images seems to be an important in vivo OCT characteristic for differentiating iBCC aggressive subtypes from sBCC and nBCC.…”

Section: Discussionmentioning

confidence: 95%

In vivo differentiation of common basal cell carcinoma subtypes by microvascular and structural imaging using dynamic optical coherence tomography

Themstrup

Carvalho

Nielsen

et al. 2018

Experimental Dermatology

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The subtype of basal cell carcinoma (BCC) influences the choice of treatment. Optical coherence tomography (OCT) is a non-invasive imaging tool, and a recent development of an angiographic version of OCT has extended the application of OCT to image the cutaneous microvasculature (so-called dynamic OCT, D-OCT). This study explores D-OCT's ability to differentiate the common BCC subtypes by microvascular and structural imaging. Eighty-one patients with 98 BCC lesions, consisting of three subtypes: 27 superficial BCC (sBCC), 55 nodular BCC (nBCC) and 16 infiltrative BCC (iBCC) were D-OCT scanned at three European dermatology centres. Blinded evaluations of microvascular and structural features were performed, followed by extensive statistical analysis of risk ratio (RR) and multiple correspondence analysis. nBCC lesions displayed most characteristic structural and vascular features. Serpiginous vessels, branching vessels, vessels creating a circumscribed figure and sharply demarcated hyporeflective ovoid structures in the dermis were all associated with a higher risk of the subtype being nBCC. The presence of highly present lines and dark peripheral borders at the margin of ovoid structures was negatively associated with iBCC. Lastly, the finding of hyporeflective ovoid structures protruding from epidermis correlated with sBCC. We identified various microvascular and structural D-OCT features that may aid non-invasive identification of BCC subtypes. This would allow clinicians to individualize and optimize BCC treatment as well as aid follow-up of non-surgical treatment.

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Section: Discussionmentioning

confidence: 95%

In vivo differentiation of common basal cell carcinoma subtypes by microvascular and structural imaging using dynamic optical coherence tomography

Themstrup

Carvalho

Nielsen

et al. 2018

Experimental Dermatology

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“…There are three main histological subtypes of BCC, namely, nodular, superficial, and infiltrative (including morpheaform), although tumors may present a combination of at least two of the aforementioned subtypes; in this case, they are classified as mixed tumors (Rippey, ). The infiltrative/morpheaform subtypes and the micronodular variant of the nodular BCC are considered more aggressive (Mackiewicz‐Wysocka, Bowszyc‐Dmochowska, Strzelecka‐Węklar, Dańczak‐Pazdrowska, & Adamski, ).…”

Section: Histological Featuresmentioning

confidence: 99%

Scalp basal cell carcinoma: A different entity?

Castanheira

Soares

Boaventura

2019

Dermatologic Therapy

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Basal cell carcinoma is the most frequent malignant neoplasm in white‐skinned individuals. It develops in different body areas, including in the scalp, which is a unique anatomical region due to the high number of pilosebaceous follicles; the scalp is protected from UV exposure, a main risk factor for basal cell carcinoma development. Moreover, scalp basal cell carcinoma has been described as more aggressive and difficult to treat than other forms of basal cell carcinoma. In this study, we reviewed the clinical and pathological characteristics, risk factors, genetics, and treatment options for scalp basal cell carcinoma to better understand this special type of cancer. Even though it is not yet clear whether scalp basal cell carcinomas represent a different entity, it seems important to give them special attention due to their potential aggressiveness, invasion capacities, tendency to relapse, and treatment difficulties.

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“…This prevalence is projected to increase twice in every 25 years, with the ratio becoming 3:2 [4]. Most BCCs are located on the upper parts of the body, with 75-80% located on the face making BCC although only locally destructive cosmetically damaging [5–7]. …”

Section: Introductionmentioning

confidence: 99%

Basal Cell Carcinoma Arises from Interfollicular Layer of Epidermis

Tan

Ghaznawie

Heenan³

et al. 2018

Journal of Oncology

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Background BCC is currently the most common type of skin cancer in humans. Although having a low-grade malignancy and metastatic potential, BCC is locally aggressive and destructive. Despite numerous studies, the origin of BCC, whether arising from the follicular or interfollicular layer, remains controversial. Objectives This study aims to evaluate whether BCC arises from the follicular or interfollicular layer by using immunohistochemical staining. Methods Twenty-three specimens of superficial and nodular BCC at its very early stage were examined. The samples were immunohistochemically stained using BerEP4 antibody. The stained specimens were then examined and scored by 2 independent observers. Results BerEP4 was found to be strongly positive in all BCC lesions, including a very early lesions budding off the basal layer of the epidermis. Conclusion This study confirmed that the origin site of BCC is basal layer of epidermis. This finding suggests that BCC arises from the interfollicular epidermis.

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Reviews Basal cell carcinoma – diagnosis

Cited by 52 publications

References 30 publications

In vivo differentiation of common basal cell carcinoma subtypes by microvascular and structural imaging using dynamic optical coherence tomography

In vivo differentiation of common basal cell carcinoma subtypes by microvascular and structural imaging using dynamic optical coherence tomography

Scalp basal cell carcinoma: A different entity?

Basal Cell Carcinoma Arises from Interfollicular Layer of Epidermis

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