The article is devoted to sociotechnical system management in the network society. The characteristic peculiarities of the sociotechnical system functioning are described by means of systemic methodology within the socio-anthropology approach. It has been empathized that the sophisticated system can not function without human involvement and outside the sociocultural environment where it exists. A multicomponent sociotechnical system includes noneconomic intangible assets in the form of the nominal capital to which, in particular, ecological, intellectual, ethnocultural and ethical ties are referred besides traditional technological structures and economic indicators. Coordinating all these aspects of such system functioning has become an unconventional scientific, engineering and organizational task. Artificial objects and systems created based on modern technologies, particularly biotechnologies and genetic engineering, as well as the informational and intellectual technology, can not be considered conventional either for technologies or sciences and humanities. It has been proved that system management factors are rooted in the communication system possessing a matrix structure, ultimately based on value paradigms and conventional norms of the intellectual, professional and corporate culture.