Review: the role of omega 3 fatty acids in intestinal inflammation

Teitelbaum, Jonathan E.; Walker, W. Allan

doi:10.1016/s0955-2863(00)00141-8

Cited by 121 publications

(85 citation statements)

References 82 publications

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“…In addition to resolvins, it is now appreciated that several new families of endogenous antiinf lammatory and͞or proresolution mediators are generated during a host response, including TGF-␤, IL-10, peroxisome proliferator-activated receptor (PPAR) ␥ agonists, and lipoxins (14 -17). Studies in humans suggested that omega-3 PUFA such as EPA and docosahexaenoic acid are protective in reducing the rates of relapse in Crohn's disease (4,5). These results raise the intriguing possibility that omega-3 PUFA is a precursor of endogenous resolution signals.…”

Section: Discussionmentioning

confidence: 99%

“…Omega-3 polyunsaturated fatty acids (PUFA) such as eicosapentaenoic acid (EPA) and docosahexaenoic acid, which are enriched in fish oils, are held to be beneficial in a wide range of human inflammatory disorders, including cardiovascular diseases, rheumatoid arthritis, Alzheimer's disease, lung fibrosis, and inflammatory bowel disease (IBD) (2)(3)(4)(5). These essential fatty acids are widely believed to act by means of several possible mechanisms, such as preventing conversion of arachidonate to proinflammatory eicosanoids or serving as an alternative substrate producing less potent products.…”

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confidence: 99%

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Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis

Arita

Yoshida

Hong

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

537

437

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Resolvin E1 (RvE1; 5S,12R,18R-trihydroxyeicosapentaenoic acid) is an antiinflammatory lipid mediator derived from omega-3 fatty acid eicosapentaenoic acid (EPA). At the local site of inflammation, aspirin treatment enhances EPA conversion to 18R-oxygenated products, including RvE1, which carry potent antiinflammatory signals. Here, we obtained evidence for reduced leukocyte infiltration in a mouse peritonitis model, where the administration of EPA and aspirin initiated the generation of RvE1 in the exudates. Similar results were obtained with the administration of synthetic RvE1, which blocked leukocyte infiltration. RvE1 also protected against the development of 2,4,6-trinitrobenzene sulfonic acidinduced colitis. The beneficial effect was reflected by increased survival rates, sustained body weight, improvement of histologic scores, reduced serum anti-2,4,6-trinitrobenzene sulfonic acid IgG, decreased leukocyte infiltration, and proinflammatory gene expression, including IL-12 p40, TNF-␣, and inducible nitric oxide synthase. Thus, the endogenous lipid mediator RvE1 counterregulates leukocyte-mediated tissue injury and proinflammatory gene expression. These findings show an endogenous mechanism that may underlie the beneficial actions of omega-3 EPA and provide targeted approaches for the treatment of intestinal inflammation.antiinflammation ͉ aspirin-triggered lipid mediators ͉ omega-3 PUFA ͉ resolvins

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis

Arita

Yoshida

Hong

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

537

437

View full text Add to dashboard Cite

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“…The control group, fed with oil rich in LA, presented the greatest number of lymphocytes in the intestinal mucosa, probably due to the inflammatory response to AA, resulting from the LA metabolism 27 . Although the modulatory role of the inflammatory response depends on the concentrations of -6/ -3 in the diet, soybean oil presented an inflammatory response superior to olive oil which presented a greater -6/ -3 relation.…”

Section: Discussionmentioning

confidence: 99%

Flaxseed, olive and fish oil influence plasmatic lipids, lymphocyte migration and morphometry of the intestinal of Wistar rats

Rosa¹,

Sales²,

Moraes³

et al. 2010

Acta Cir. Bras.

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Purpose: Evaluate the effect of flaxseed, olive and fish oil on the lipid profile, preservation of villosities and lymphocyte migration in the intestinal mucosa of Wistar rats. Methods: Thirty Wistar male rats were divided into four groups, which received the AIN-93M diet, with changes only to their lipid source: flaxseed, olive, fish, and soy oil (control group). The serum was separated for the biochemical parameter analysis. A histological evaluation was performed in the ileal portion. Results: The group which was fed fish oil presented lower values when compared to the other treatments for Total Cholesterol, High-density Lipoprotein Cholesterol and Triacylglycerol (p<0.05). The animals treated with fish and olive oils presented better intestinal villosities preservation. Less deposition of lymphocytes was observed in the flaxseed group (p<0.001). Conclusions: This study demonstrated that flaxseed, olive and fish oils present different responses than soy oil for the intestinal mucosa preservation and lymphocyte proliferation in Wistar rats. Key words: Vegetable Fats. Linseed Oil. Soybean Oil. Fish Oils. Morphology. Intestines. Lymphocytes. Rats. RESUMO Objetivo:Avaliar o efeito dos óleos de linhaça, oliva e peixe no perfil lipídico, preservação das vilosidades e migração de linfócitos na mucosa intestinal de ratos Wistar. Métodos: Trinta ratos Wistar foram divididos em quarto grupos e receberam dieta AIN-93M, modificando para cada grupo apenas a fonte lipídica: óleo de linhaça, oliva, peixe e soja ( grupo controle). O soro foi separado para análise dos parâmetros bioquímicos. A análise histológica foi realizada na porção ileal. Resultados: O grupo que recebeu óleo de peixe apresentou menores valores de colesterol total, lipoproteína de alta densidade e triacilglicerol (p<0.05). Os animais tratados com óleo de peixe e oliva apresentaram melhor preservação das vilosidades intestinais. Menor deposição de linfócitos foi observado no grupo tratado com óleo de linhaça (p<0.001). Conclusão: Este estudo demonstrou que os óleos de linhaça, oliva e peixe apresentam diferentes respostas em relação ao óleo de soja na preservação da mucosa intestinal e proliferação de linfócitos em ratos Wistar. Descritores: Gorduras Vegetais. Óleo de Semente do Linho. Óleo de Soja. Óleos de Peixe. Morfologia. Intestino. Linfócitos. Ratos.

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“…N umerous reports demonstrate the beneficial effects of fish oil on human diseases such as arthritis, Alzheimer's disease, lung fibrosis, and inflammatory bowel diseases [1][2][3]. As an essential -3 polyunsaturated fatty acid, docosahexaenoic acid (DHA) is a major component of fish oil [4].…”

mentioning

confidence: 99%

Resolvin D1, protectin D1, and related docosahexaenoic acid-derived products: Analysis via electrospray/low energy tandem mass spectrometry based on spectra and fragmentation mechanisms

Hong

Lü

Rong

et al. 2007

J. Am. Soc. Mass Spectrom.

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Resolvin D1 (RvD1) and protectin D1 (Neuroprotectin D1, PD1/NPD1) are newly identified anti-inflammatory lipid mediators biosynthesized from docosahexaenoic acid (DHA). In this report, the spectra-structure correlations and fragmentation mechanisms were studied using electrospray low-energy collision-induced dissociation tandem mass spectrometry (MS/MS) for biogenic RvD1 and PD1, as well as mono-hydroxy-DHA and related hydroperoxy-DHA. The loss of H 2 O and CO 2 in the spectra indicates the number of functional group(s). Chain-cut ions are the signature of the positions and numbers of functional groups and double bonds. The observed chain-cut ion is equivalent to a hypothetical homolytic-segment (cc, cm, mc, or mm) with addition or extraction of up to 2 protons (H). The ␣-cleavage ions are equivalent to: [cc ϩ H], with H from the hydroxyl through a ␤-ene or ␥-ene rearrangement; [cm Ϫ 2H], with 2H from hydroxyls of PD1 through a ␥-ene rearrangement, or 1H from the hydroxyl and the other H from the ␣-carbon of mono-HDHA through an ␣-H-␤-ene rearrangement; [mc Ϫ H], with H from hydroxyl through a ␤-ene or ␥-ene rearrangement, or from the ␣-carbon through an ␣-H-␤-ene rearrangement; or [mm] through charge-direct fragmentations. The ␤-ene or ␥-ene facilitates the H shift to ␥ position and ␣-cleavage. Deuterium labeling confirmed the assignment of MS/MS ions and the fragmentation mechanisms. Based on the MS/MS spectra and fragmentation mechanisms, we identified RvD1, PD1, and mono-hydroxy-DHA products in human neutrophils and blood, trout head-kidney, and stroke-injury murine braintissue. (J Am Soc Mass Spectrom 2007, 18, 128 -144)

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Review: the role of omega 3 fatty acids in intestinal inflammation

Cited by 121 publications

References 82 publications

Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis

Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis

Flaxseed, olive and fish oil influence plasmatic lipids, lymphocyte migration and morphometry of the intestinal of Wistar rats

Resolvin D1, protectin D1, and related docosahexaenoic acid-derived products: Analysis via electrospray/low energy tandem mass spectrometry based on spectra and fragmentation mechanisms

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