Review The effects of selected drugs and dietary compounds on proliferation and apoptosis in colorectal carcinoma

Kiedrowski, Mirosław; Mróz, Andrzej

doi:10.5114/wo.2014.44296

Cited by 6 publications

(5 citation statements)

References 30 publications

(29 reference statements)

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“…The increased level of PARP expression associated to the activation of caspase-3 and caspase-9 further confirmed the effectiveness of combined treatment in both parental and resistant cells in inducing apoptosis. Several therapeutics tend to eliminate transformed cells by the induction of apoptosis through activation of the effector caspases 60 . Our result suggests the therapeutic role of concomitant use of Kaempferol and 5-Fluorouracil for resistant colorectal cancer to 5-fluorouracil.…”

Section: Discussionmentioning

confidence: 99%

The Phenolic compound Kaempferol overcomes 5-fluorouracil resistance in human resistant LS174 colon cancer cells

Riahi-Chebbi

Souid

Othman

et al. 2019

Sci Rep

105

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Resistance to 5-Fluorouracil chemotherapy is a major cause of therapeutic failure in colon cancer cure. Development of combined therapies constitutes an effective strategy to inhibit cancer cells and prevent the emergence of drug resistance. For this purpose, we investigated the anti-tumoral effect of thirteen phenolic compounds, from the Tunisian quince Cydonia oblonga Miller, alone or combined to 5-FU, on the human 5-FU-resistant LS174-R colon cancer cells in comparison to parental cells. Our results showed that only Kaempferol was able to chemo-sensitize 5-FU-resistant LS174-R cells. This phenolic compound combined with 5-FU exerted synergistic inhibitory effect on cell viability. This combination enhanced the apoptosis and induced cell cycle arrest of both chemo-resistant and sensitive cells through impacting the expression levels of different cellular effectors. Kaempferol also blocked the production of reactive oxygen species (ROS) and modulated the expression of JAK/STAT3, MAPK, PI3K/AKT and NF-κB. In silico docking analysis suggested that the potent anti-tumoral effect of Kaempferol, compared to its two analogs (Kaempferol 3-O-glucoside and Kampferol 3-O-rutinoside), can be explained by the absence of glucosyl groups. Overall, our data propose Kaempferol as a potential chemotherapeutic agent to be used alone or in combination with 5-FU to overcome colon cancer drug resistance.

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Section: Discussionmentioning

confidence: 99%

The Phenolic compound Kaempferol overcomes 5-fluorouracil resistance in human resistant LS174 colon cancer cells

Riahi-Chebbi

Souid

Othman

et al. 2019

Sci Rep

105

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“…Moderately activated apoptosis helps to clear unwanted cells such as dead white blood cells in immune responses or cells with harmful mutations caused by external stimuli [ 194 , 195 ]. The balance between cell growth, dormancy, apoptosis is of great importance to maintain homeostasis while dysregulation of this harmonious relationship is an underlying mechanism of tumorigenesis and is also regarded as a hallmark of cancers [ 155 , 196 , 197 ]. The well-accepted apoptotic features include cell contraction, chromatin aggregation, and DNA ladder formation caused by internucleosomal DNA fragmentation, which ends with phagocytosis by macrophages or adjacent cells, thus avoiding inflammatory reactions among surrounding tissues [ 198 ].…”

Section: Melatonin and Androgen Receptor (Ar) Pathwaymentioning

confidence: 99%

The inhibitory effect of melatonin on human prostate cancer

Shen

Zhou

et al. 2021

Cell Commun Signal

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Prostate cancer (PCa) is one of the most commonly diagnosed human cancers in males. Nearly 191,930 new cases and 33,330 new deaths of PCa are estimated in 2020. Androgen and androgen receptor pathways played essential roles in the pathogenesis of PCa. Androgen depletion therapy is the most used therapies for primary PCa patients. However, due to the high relapse and mortality of PCa, developing novel noninvasive therapies have become the focus of research. Melatonin is an indole-like neurohormone mainly produced in the human pineal gland with a prominent anti-oxidant property. The anti-tumor ability of melatonin has been substantially confirmed and several related articles have also reported the inhibitory effect of melatonin on PCa, while reviews of this inhibitory effect of melatonin on PCa in recent 10 years are absent. Therefore, we systematically discuss the relationship between melatonin disruption and the risk of PCa, the mechanism of how melatonin inhibited PCa, and the synergistic benefits of melatonin and other drugs to summarize current understandings about the function of melatonin in suppressing human prostate cancer. We also raise several unsolved issues that need to be resolved to translate currently non-clinical trials of melatonin for clinic use. We hope this literature review could provide a solid theoretical basis for the future utilization of melatonin in preventing, diagnosing and treating human prostate cancer.

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“…The development of many malignancies is believed to be a consequence of an imbalance between the compromised process of programmed cell death (apoptosis) and excessive, uncontrolled proliferation . Typically, induction of apoptosis is a strategy for reducing cancer development .…”

Section: Effect Of Melatonin On Gastrointestinal Cancer Cell Apoptosismentioning

confidence: 99%

Melatonin as a treatment for gastrointestinal cancer: a review

Xin

Jiang

et al. 2015

Journal of Pineal Research

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Gastrointestinal cancer is a disease that affects the population worldwide with high morbidity and mortality. Melatonin, an endogenously produced molecule, may provide a defense against a variety of cancer types. In particular, the ability of melatonin to inhibit gastrointestinal cancer is substantial. In this review, we first clarify the relationship between the disruption of the melatonin rhythm and gastrointestinal cancer (based on epidemiologic surveys and animal and human studies) and summarize the preventive effect of melatonin on carcinogenesis. Thereafter, the mechanisms through which melatonin exerts its anti-gastrointestinal cancer actions are explained, including inhibition of proliferation, invasion, metastasis, and angiogenesis, and promotion of apoptosis and cancer immunity. Moreover, we discuss the drug synergy effects and the role of melatonin receptors involved in the growth-inhibitory effects on gastrointestinal cancer. Taken together, the information compiled here serves as a comprehensive reference for the antigastrointestinal cancer actions of melatonin that have been identified to date and will hopefully aid in the design of further experimental and clinical studies and increase the awareness of melatonin as a therapeutic agent in cancers of the gastrointestinal tract.

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Review The effects of selected drugs and dietary compounds on proliferation and apoptosis in colorectal carcinoma

Cited by 6 publications

References 30 publications

The Phenolic compound Kaempferol overcomes 5-fluorouracil resistance in human resistant LS174 colon cancer cells

The Phenolic compound Kaempferol overcomes 5-fluorouracil resistance in human resistant LS174 colon cancer cells

The inhibitory effect of melatonin on human prostate cancer

Melatonin as a treatment for gastrointestinal cancer: a review

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