Review: Systemic consequences of COPD

Tkáč, Ján; Man, S. F. Paul; Sin, Don D.

doi:10.1177/1753465807082374

Cited by 28 publications

(13 citation statements)

References 84 publications

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“…However, it remains unclear whether systemic inflammation is a cause of cardiovascular disease, or merely a marker [27]. In any case, over the past 5 years, several other plausible explanations, such as increased oxidative stress, neurohumoral disturbances, and increased thrombotic tendency, have been provided [28]. All are very intriguing, but none is really definite.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Comorbidities in Patients with Chronic Obstructive Pulmonary Disease

et al. 2010

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Background: Chronic obstructive pulmonary disease (COPD) is associated with many comorbidities, but the percentage of COPD patients who develop comorbidities has not been clearly defined. Objectives: We aimed to examine the relationship between COPD and comorbidities using information obtained from the Health Search Database (HSD) owned by the Italian College of General Practitioners (SIMG), which stores information on about 1.5% of the total Italian population served by general practitioners. Methods: We conducted a population-based retrospective study using information obtained from the HSD. The software system used codes all the diagnostic records using the 9th Revision of the International Classification of Diseases. Results: Compared to the non-COPD people, COPD patients were at increased risk for cardiovascular events [ischemic heart disease (6.9% in the general population vs. 13.6% in COPD patients), cardiac arrhythmia (6.6% in the general population vs. 15.9% in COPD patients), heart failure (2.0% in the general population vs. 7.9% in COPD patients), and other forms of heart disease (10.7% in the general population vs. 23.1% in COPD patients); with a higher impact of COPD in the elderly]; non-psychotic mental disorders, including depressive disorders (29.1% in the general population vs. 41.6% in COPD patients; with a higher impact of COPD on women aged <75 years); diabetes mellitus (10.5% in the general population vs. 18.7% in COPD patients); osteoporosis (10.8% in the general population vs. 14.8% in COPD patients), with a higher impact of COPD on women aged <75 years, and malignant pulmonary neoplasms (0.4% in the general population vs. 1.9% in COPD patients). Conclusions: Our results indicate that COPD is a risk factor for these comorbid conditions.

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Section: Discussionmentioning

confidence: 99%

Prevalence of Comorbidities in Patients with Chronic Obstructive Pulmonary Disease

et al. 2010

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“…It has been suggested that impaired lung functioning causes changes in the central nervous system through processes such as cerebral diseases resulting from impaired fibrinolytic activity, oxidate stress, [99] vascular diseases, and increased proinflammatory cytokines such as TNFR1 that act as a possible systemic mediator via cardiovascular disease between lung functions and brain [45]. Increases in the circulating levels of thrombotic factors may be expected to elevate the risk for cardiovascular disease [104]. In other words, cognitive deficits are mediated by the presence of changes in systemic hemodynamic and cerebral diseases.…”

Section: Mechanism Of Cognitive Impairment In Copd and Osas Patientsmentioning

confidence: 99%

Effects of Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnea on Cognitive Functions: Evidence for a Common Nature

2014

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Patients with chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea syndrome (OSAS) show similar neurocognitive impairments. Effects are more apparent in severe cases, whereas in moderate and mild cases the effects are equivocal. The exact mechanism that causes cognitive dysfunctions in both diseases is still unknown and only suggestions have been made for each disease separately. The primary objective of this review is to present COPD and OSAS impact on cognitive functions. Secondly, it aims to examine the potential mechanisms by which COPD and OSAS can be linked and provide evidence for a common nature that affects cognitive functions in both diseases. Patients with COPD and OSAS compared to normal distribution show significant deficits in the cognitive abilities of attention, psychomotor speed, memory and learning, visuospatial and constructional abilities, executive skills, and language. The severity of these deficits in OSAS seems to correlate with the physiological events such as sleep defragmentation, apnea/hypopnea index, and hypoxemia, whereas cognitive impairments in COPD are associated with hypoventilation, hypoxemia, and hypercapnia. These factors as well as vascocerebral diseases and changes in systemic hemodynamic seem to act in an intermingling and synergistic way on the cause of cognitive dysfunctions in both diseases. However, low blood oxygen pressure seems to be the dominant factor that contributes to the presence of cognitive deficits in both COPD and OSAS.

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“…En EPOc avanzada es común la pérdida de peso y la caquexia. también se observa, en mayor proporción respecto población de edad similar, una disminución de la masa muscular y mayor frecuencia de comorbilidades como osteoporosis, insuficiencia cardiaca, enfermedad cardiaca isquémica, accidente vascular cerebral, depresión y cáncer 33 . Un estudio español 34 , mostró en pacientes con EPOc exacerbado una alta frecuencia de hipertensión arterial, de insuficiencia cardiaca y de diabetes mellitus.…”

Section: Comorbilidades Y Consecuencias Sistémicasunclassified

Enfermedad pulmonar obstructiva crónica: Mirada actual a una enfermedad emergente

Silva

2010

Rev. méd. Chile

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Update on chronic obstructive pulmonary diseaseChronic obstructive pulmonary disease (COPD), mainly caused by smoking, is predicted to be the third most frequent cause of death in the world by 2020. It is a multicomponent, progressive, disabling condition that ultimately ends in respiratory failure and death. There is evidence that systemic inflammation and extra pulmonary effects are also common in COPD, although the association between systemic inflammation and systemic manifestations of COPD is still not entirely clear. COPD is not only preventable but also treatable and the past decade has witnessed great progress in COPD research. New drugs have been developed and tested and a growing base of scientific evidence now documents the efficacy of several therapies for symptoms and exacerbations. It is clear that many patients with the disease can benefit from an aggressive management, with a decrease in the frequency of hospitalizations and improvements in symptoms and quality of life. Moreover, basic and clinical scientists have now identified cells, mechanisms, and molecules that play key roles in its pathogenesis. The advent of newer and more effective therapies will lead to a decline in the contribution of this disease to worldwide disease burden. COPD is now viewed under a new paradigm as preventable and treatable. (Rev Med Chile 2010; 138: 1544-1552.

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Review: Systemic consequences of COPD

Cited by 28 publications

References 84 publications

Prevalence of Comorbidities in Patients with Chronic Obstructive Pulmonary Disease

Prevalence of Comorbidities in Patients with Chronic Obstructive Pulmonary Disease

Effects of Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnea on Cognitive Functions: Evidence for a Common Nature

Enfermedad pulmonar obstructiva crónica: Mirada actual a una enfermedad emergente

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