Review on spectroscopic analytical methods for determination of metformin hydrochloride

Abstract

Simple sensitive methods to estimate the metformin hydrochloride. It works to reduce blood glucose level in NIDDM patients. Metformin is a biguanide anti hyperglycemic agent. It works by decreasing glucose production by the liver and increasing the insulin sensitivity of body tissues. Literature survey reveals analytical methods such as UV Spectrophotometry, liquid chromatography, gas chromatography, GC-MS , flow injection fluorescence and flow injection MS/MS, have been reported for estimation of the metformin hydrochloride in pharmaceutical formulations and biological fluids.

Advances in metformin‐delivery systems for diabetes and obesity management

“…The pH level plays a critical role in determining the stability of biguanides. 7 Metformin is more susceptible to degradation from UV light than white light.…”

“…Biguanides quickly degrade when exposed to environmental conditions, and their salts are particularly susceptible to degradation. The pH level plays a critical role in determining the stability of biguanides 7 . Metformin is more susceptible to degradation from UV light than white light.…”