Review on Niosomes - a Novel Approach for Drug Targeting

Sudheer, Preethi; Kar, Kaushik

doi:10.18579/jpcrkc/2015/14/1/78376

Cited by 18 publications

(19 citation statements)

References 22 publications

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“…Using the Malvern Zetasizer Nano, it was found that the average size of the majority of the green tea extract niosomes vesicles was 1109 nm or 1.109 µm and the particle distribution showed a PdI of 0.856 (Table 3). These niosomes can be classified as large unilamellar vesicles because the size of the vesicles was more than 0.10 µm (Sudheer & Kaushik, 2015). It was also found that the particle size distribution of green tea extract niosomes was very broad, because they had a PdI value >0.7 (Nidhin et al, 2008).…”

Section: Niosomes Characterisationmentioning

confidence: 97%

Thin-layer hydration method to prepare a green tea extract niosomal gel and its antioxidant performance

Chasanah

Mahmintari

Hidayah

et al. 2021

European Pharmaceutical Journal

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This study aimed to prepare a niosomal gel of green tea (Camellia sinensis) extract containing catechins, mostly epigallocatechin-3-gallate (ECGC), as a potent antioxidant. Niosomes can increase EGCG's stability and penetration into the skin for a better therapeutic effect. Niosomes were prepared by a thin-layer hydration method, were evaluated for their vesicle shape, particle size, polydispersity index, zeta potential and entrapment efficiency, and then incorporated into gels using sodium alginate as a gelling agent. Three niosomal gel formulations were prepared with different concentrations of niosomes green tea extract. Afterwards, organoleptic properties, chemical and physical characteristics, antioxidant activity, and stability and irritability of the niosomal gels were investigated. The different concentrations of green tea extract had a significant effect on the physical characteristics, but not on the chemical ones. Its antioxidant activity was determined using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging method. The 50% extract green tea niosomes gel showed the highest inhibition value (25.13%). The stability was determined by freeze–thaw and real-time methods; they showed a decrease in pH, but still within the pH range of skin. The irritability test used was the Hen's Egg Test-Chorioallantoic Membrane (HET-CAM) method, which showed no irritation for all formulas. In conclusion, 50% green tea extract niosomes gel results showed it to be the best formulation with optimal antioxidant results.

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Section: Niosomes Characterisationmentioning

confidence: 97%

Thin-layer hydration method to prepare a green tea extract niosomal gel and its antioxidant performance

Chasanah

Mahmintari

Hidayah

et al. 2021

European Pharmaceutical Journal

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“…Specialized niosomes are called proniosomes; these are nonionic based surfactant vesicles, which are hydrated immediately before use to yield aqueous niosome dispersions. To enhance drug delivery in addition to conventional niosomes, proniosomes are also being used [ 41 , 42 ].…”

Section: Novel Nanocarriers For Cosmeceuticalsmentioning

confidence: 99%

Role of Nanotechnology in Cosmeceuticals: A Review of Recent Advances

Kaul

Gulati

Verma

et al. 2018

Journal of Pharmaceutics

231

212

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Nanotechnology manifests the progression in the arena of research and development, by increasing the efficacy of the product through delivery of innovative solutions. To overcome certain drawbacks associated with the traditional products, application of nanotechnology is escalating in the area of cosmeceuticals. Cosmeceuticals are regarded as the fastest growing segment of the personal care industry and the use has risen drastically over the years. Nanocosmeceuticals used for skin, hair, nail, and lip care, for conditions like wrinkles, photoaging, hyperpigmentation, dandruff, and hair damage, have come into widespread use. Novel nanocarriers like liposomes, niosomes, nanoemulsions, microemulsion, solid lipid nanoparticles, nanostructured lipid carrier, and nanospheres have replaced the usage of conventional delivery system. These novel nanocarriers have advantages of enhanced skin penetration, controlled and sustained drug release, higher stability, site specific targeting, and high entrapment efficiency. However, nanotoxicological researches have indicated concern regarding the impact of increased use of nanoparticles in cosmeceuticals as there are possibilities of nanoparticles to penetrate through skin and cause health hazards. This review on nanotechnology used in cosmeceuticals highlights the various novel carriers used for the delivery of cosmeceuticals, their positive and negative aspects, marketed formulations, toxicity, and regulations of nanocosmeceuticals.

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“…The samples are taken out at suitable time intervals, replaced with fresh media and analyzed for drug content. 28…”

Section: Franz Diffusion Cellmentioning

confidence: 99%

A Review on Niosomes: Potential Vesicular Drug Delivery System

Kumavat¹,

Sharma²,

Koka³

et al. 2021

J. Drug Delivery Ther.

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Over the years researchers have been making an attempt to improve the potency of utilization of medicament for treatment of numerous diseases. During this endeavour, drug delivery systems have helped greatly by achieving reduced dose, reduced dosage frequency, improved patient compliance, improved bioavailability and maximum concentration of the drug at the target site. Recent years have seen an unprecedented growth in the use of nanotechnology in designing drug delivery systems. Niosomes are vesicles composed of non-ionic surfactants, which are biodegradable, comparatively non-toxic, stable, economical and effective alternate to liposomes. This review is deepening and widening the interest of Niosomes in several scientific disciplines and notably its application in drug delivery. This review additionally presents a summary of the types, methods of preparation, characterization and applications of Niosomes. Keywords: Niosomes, types, method of preparation, factors affecting and applications

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Review on Niosomes - a Novel Approach for Drug Targeting

Cited by 18 publications

References 22 publications

Thin-layer hydration method to prepare a green tea extract niosomal gel and its antioxidant performance

Thin-layer hydration method to prepare a green tea extract niosomal gel and its antioxidant performance

Role of Nanotechnology in Cosmeceuticals: A Review of Recent Advances

A Review on Niosomes: Potential Vesicular Drug Delivery System

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