Review on natural products as an alternative to contemporary anti-leishmanial therapeutics

Raj, Shweta; Sasidharan, Santanu; Balaji, S.; Dubey, Vikash Kumar; Saudagar, Prakash

doi:10.1007/s42485-020-00035-w

Cited by 25 publications

(17 citation statements)

References 155 publications

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“…For Leishmania, compounds from diverse plant sources and their modified analogs have been tagged with nanoparticles to explore potential mechanisms to increase the delivery, efficacy, and bioavailability of these compounds. [26] The leishmanicidal activity of Asteraceae has been widely studied, including multiple ethanol extracts, [27] SLs (which are characteristic Asteraceae chemomarkers), [5] flavonoids, [28] tannins and steroids. Some secondary metabolites found to efficiently treat experimental leishmaniasis include ferulic acid, rosmarinic acid, and ursolic acid.…”

Section: Computational Studies Against Leishmaniamentioning

confidence: 99%

Discovery of Alternative Chemotherapy Options for Leishmaniasis through Computational Studies of Asteraceae

et al. 2021

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Leishmaniasis is a complex disease caused by over 20Leishmania species that primarily affects populations with poor socioeconomic conditions. Currently available drugs for treating leishmaniasis include amphotericin B, paromomycin, and pentavalent antimonials, which have been associated with several limitations, such as low efficacy, the development of drug resistance, and high toxicity. Natural products are an interesting source of new drug candidates. The Asteraceae family includes more than 23 000 species worldwide. Secondary metabolites that can be found in species from this family have been widely explored as potential new treatments for leishmaniasis. Recently, computational tools have become more popular in medicinal chemistry to establish experimental designs, identify new drugs, and compare the molecular structures and activities of novel compounds. Herein, we review various studies that have used computational tools to examine various compounds identified in the Asteraceae family in the search for potential drug candidates against Leishmania.

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Section: Computational Studies Against Leishmaniamentioning

confidence: 99%

Discovery of Alternative Chemotherapy Options for Leishmaniasis through Computational Studies of Asteraceae

et al. 2021

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“…The chemical diversity and complexity of natural compounds have always fascinated researchers regarding their pharmacological potential. Plant extracts and phytochemicals of various classes have been reported to possess antileishmanial properties (Scotti et al 2016 ; Boniface and Ferreira 2019 ; Gonçalves et al 2020 ; Raj et al 2020 ). Among these classes, iridoids comprise a vastly diverse group of cyclopenta[c]pyran monoterpenoids (Raj et al 2020 ).…”

Section: Approaches To Find New Antileishmanial Agents From Plantsmentioning

confidence: 99%

“…Plant extracts and phytochemicals of various classes have been reported to possess antileishmanial properties (Scotti et al 2016 ; Boniface and Ferreira 2019 ; Gonçalves et al 2020 ; Raj et al 2020 ). Among these classes, iridoids comprise a vastly diverse group of cyclopenta[c]pyran monoterpenoids (Raj et al 2020 ). Throughout the past decades, extensive investigations have been conducted and attributed various biological activities to this class, including antileishmanial properties (Raj et al 2020 ; Tundis et al 2008 ).…”

Section: Approaches To Find New Antileishmanial Agents From Plantsmentioning

confidence: 99%

“…Among these classes, iridoids comprise a vastly diverse group of cyclopenta[c]pyran monoterpenoids (Raj et al 2020 ). Throughout the past decades, extensive investigations have been conducted and attributed various biological activities to this class, including antileishmanial properties (Raj et al 2020 ; Tundis et al 2008 ).…”

Section: Approaches To Find New Antileishmanial Agents From Plantsmentioning

confidence: 99%

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Revisiting nature: a review of iridoids as a potential antileishmanial class

2021

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Leishmaniasis still stands as one of the most prevalent neglected tropical diseases in the least developed and emerging countries. The recommended therapeutic arsenal to treat leishmaniasis is characterized by several shortcomings, and resistance has already been reported. Hence, this dramatic background highlights the pressing need to develop novel, affordable, and safe antileishmanial drugs. Multiple classes of natural compounds have been reported to possess antileishmanial activity. Among these classes, iridoids stand out as a special type of monoterpenoids with diverse biological properties—including their antileishmanial potential. This review aims to discuss the available literature between 1991 and 2020 related to the antileishmanial activity of the iridoid class. Throughout the past decades, various investigations attributed antileishmanial action to assorted iridoid types, including inhibitory potential towards validated drug targets and immunomodulatory activity. The latter deserves special attention due to the ability of some iridoids to improve the host’s immune response against parasites. It opens the possibility of iridoids become adjuncts in leishmaniasis treatments by improving the efficacy of currently employed drugs. Furthermore, the present study intends to provide a convenient visual representation of which iridoids and Leishmania spp. species have been most investigated as a guide for further researches.

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“…Renal failure, Hepatotoxicity, leucopenia, neurotoxicity and cardiotoxicity…etc [7][8][9]. But lack of potential alternatives forced them to be dependent on these chemotherapeutic drugs [10]. Several scientific reports declared a therapeutic failure linked to the emergence of drug-resistant strains [11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

3-Methoxycarpachromene and Masticadienonic Acid as New Target Inhibitors from <em>Pistacia atlantica </em>Leaves against Trypanothione Reductase of Leishmania Parasites: In Vitro and In Silico Studies

Maamri¹,

Benarous²,

Yousfi³

2021

Preprint

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This study aimed to identify new drug molecules against Leishmania parasites, leishmaniasis's causal agent, using Pistacia atlantica leaves as source. The evaluation of the anti-leishmania potential against the promastigote form of Leishmania. infantum and Leishmania. major was performed. A new in silico study was accomplished using molecular docking, with Autodock vina program, to find the binding affinity of two important phytochemical compounds from this plant (Masticadienonic acid, 3-Methoxycarpachromene) towards the trypanothione reductase as target drugs, responsible for defence mechanism against oxidative stress and virulence of this parasites. Results: Several concentrations showed a significant decrease in cell viability (P<0.0001), with IC50 values of 0.3 mg/ mL for L. infantum and 0.12 mg/ mL L. major; The molecular docking confirms the significant relationship between Leishmania survival and the inhibition of this crucial enzyme. There were promising and new positive results on binding modes of selected ligands and the trypanothione reductase for the first time. Through this work, we propose 3-Methoxycarpachromene and Masticadienonic acid as anti Trypanosomatidae species drug.

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Review on natural products as an alternative to contemporary anti-leishmanial therapeutics

Cited by 25 publications

References 155 publications

Discovery of Alternative Chemotherapy Options for Leishmaniasis through Computational Studies of Asteraceae

Discovery of Alternative Chemotherapy Options for Leishmaniasis through Computational Studies of Asteraceae

Revisiting nature: a review of iridoids as a potential antileishmanial class

3-Methoxycarpachromene and Masticadienonic Acid as New Target Inhibitors from <em>Pistacia atlantica </em>Leaves against Trypanothione Reductase of Leishmania Parasites: In Vitro and In Silico Studies

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