Review on mechanisms and interactions in concomitant use of herbs and warfarin therapy

Leite, Paula Mendonça; Martins, Maria Auxiliadora Parreiras; Castilho, Rachel Oliveira

doi:10.1016/j.biopha.2016.06.012

Cited by 86 publications

(58 citation statements)

References 48 publications

(50 reference statements)

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“…A metaanalysis of seven randomized controlled trials including 225 participants found a mean 0.62 greater INR (95% CI = 0.46–0.78) than with placebo in participants taking acetaminophen at a daily dose of approximately 1 to 4 g/d . A number of herbal supplements that elderly adults may take potentiate the effects of warfarin or increase the risk of bleeding; these include omega‐3 fatty acids; garlic, which inhibits platelet aggregation; gingko, which is a platelet‐activating factor receptor antagonist; and saw palmetto, which inhibits cyclooxygenase and CYP2C9 …”

Section: Important Drug–drug Interactions In Older Adults In Primary mentioning

confidence: 99%

“…49 A number of herbal supplements that elderly adults may take potentiate the effects of warfarin or increase the risk of bleeding; these include omega-3 fatty acids; garlic, which inhibits platelet aggregation; gingko, which is a platelet-activating factor receptor antagonist; and saw palmetto, which inhibits cyclooxygenase and CYP2C9. 50…”

Section: Amlodipineclarithromycinmentioning

confidence: 99%

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Common Drug Side Effects and Drug‐Drug Interactions in Elderly Adults in Primary Care

Merel

Paauw

2017

J American Geriatrics Society

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Prescribing medications, recognizing and managing medication side effects and drug interactions, and avoiding polypharmacy are all essential skills in the care of older adults in primary care. Important side effects of medications commonly prescribed in older adults (statins, proton pump inhibitors, trimethoprim-sulfamethoxazole and fluoroquinolone antibiotics, zolpidem, nonsteroidal antiinflammatory drugs, selective serotonin reuptake inhibitors, dipeptidyl peptidase 4 inhibitors) were reviewed. Important drug interactions with four agents or classes (statins, warfarin, factor Xa inhibitors, and calcium channel blockers) are discussed.

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Section: Important Drug–drug Interactions In Older Adults In Primary mentioning

confidence: 99%

Section: Amlodipineclarithromycinmentioning

confidence: 99%

Common Drug Side Effects and Drug‐Drug Interactions in Elderly Adults in Primary Care

Merel

Paauw

2017

J American Geriatrics Society

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“…Aunque se sabe que la activación del sistema de coagulación es más marcada en artritis reumatoide que en osteoartritis, se ha probado su papel en la degeneración del cartílago articular (29,30) . En estas circunstancias, futuros estudios podrían estudiar si alguno de los fitocompuestos como los terpenos, que inhiben la agregación plaquetaria (31) , podrían ser la causa de esta aparente leve respuesta anticoagulante.…”

Section: Discussionunclassified

Efecto de Maytenus krukovii "Chuchuhuasi" en el tratamiento de osteoartrosis leve-moderada. Ensayo clínico aleatorizado doble-ciego, controlado con placebo.

Mendocilla-Risco¹,

Villar-López²,

Villar-Lopez³

et al. 2017

Rev. per. med. integr.

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21REV PERU MED INTEGRATIVA.2017;2(1):21-9. ResumenObjetivo. Evaluar la seguridad y eficacia de Maytenus krukovii "chuchuhuasi" a diferentes dosis, en pacientes con osteoartrosis leve-moderada. Materiales y métodos. Ensayo clínico aleatorizado, doble ciego. Se incluyeron a 50 pacientes con osteoartrosis leve-moderada (clasificación de KellgrenLawrence) por cuatro semanas; distribuidos aleatoriamente en tres grupos: I (40 mg/kg/día de M. Krukovii); II (80 mg/kg/día de M. Krukovii) y III (15 g/día de Daucus carota como placebo). Se determinó en sangre: alaninoaminotransferasa (ALT), fosfatasa alcalina (FA), depuración de creatinina, hematocrito, tiempo de protrombina, velocidad de sedimentación y recuento leucocitario. Se evaluó la función, dolor y recorrido articular mediante el test de WOMAC antes y después de la intervención. Resultados. En el grupo II se encontró una disminución estadísticamente significativa de los valores de ALT, tiempo de protrombina y velocidad de sedimentación. El tiempo de protrombina (p=0,012) y la velocidad de sedimentación entre el grupo II y el grupo placebo fueron diferentes (p=0,003). El dolor referido fue estadísticamente distinto entre ambos grupos de estudio en comparación con el placebo (p=0,001; diferencia de medias: 1,3±0,89 en ambos casos). En el caso de la capacidad funcional, solo se encontró diferencia significativa entre el grupo II y el placebo (p=0,001, diferencia de medias: 2,1±1,0). El recorrido articular de rodilla fue diferente entre el grupo I y el grupo III (p=0,004). Conclusión. El uso de M. krukovii "chuchuhuasi" a dosis de 40 y 80 mg/kg p.c. por día, mostró disminuir el dolor referido y mejorar la capacidad funcional en pacientes con diagnóstico de osteoartrosis leve a moderada. Palabras clave: Maytenus; Osteoartritis; Ensayo Clínico; Tolerancia a medicamentos (Fuente DeCS)Safety and efficacy of Maytenus krukovii "Chuchuhuasi" decoction in mild to moderate osteoarthritis. A 4-week randomized double-blind placebo-controlled clinical trial Abstract Objective.To evaluate security and efficacy of Maytenus krukovii "chuchuhuasi" in different doses in patients who had mild-moderate osteoarthritis. Materials and Methods. Randomized Clinical Trial. Fifty patients with mild-moderate osteoarthritis (Kellgren-Lawrence classification) were included in a 4-week follow-up. They were distributed in three groups: I (40mg/kg/day of M. Krukovii); II (80 mg/kg/day of M. Krukovii) y III (15 g/day of Daucus carota, which acted like placebo). Alanine aminotransferase (ALT), alkaline phosphatase, creatinine depuration, hematocrit, prothrombin time, velocity of sedimentation and leukocyte count (WBC) were measured. The articular function, pain and join path were evaluated using WOMAC questionnaire before and after intervention. Results. A significate diminution of ALT, prothrombin time and velocity of sedimentation values (before and after intervention) was found in group II. Prothrombin time (p=0.012) and velocity of sedimentation (p=0.003) were statically different between group II ...

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“…Should one of them displace warfarin by 5% (binding of warfarin would be actually 95%) means an increase of active circulating warfarin by 500 % and the effect of this change is a huge increase in antagonism of vitamin K and huge impact on hemostasis in toto. By various mechanisms many herbs influence VKA therapy, Leite et al report 58 plants in this respect [17].…”

Section: The Impact Of Nutrition-drug Interactionsmentioning

confidence: 99%

Hemorrhage After Lunch?

Télessy¹

2018

J Nutr Food Sci

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Medication induced hemorrhage during therapy with vitamin K antagonists (VKAs) is a relatively frequent adverse drug reaction. In order to minimize the risk for bleedings patients should take care of their concomitant medication and diet inclusive the dietary supplements. Here we address the question of risk factors of bleeding in patients taking warfarin and other VKAs. Special attention is paid to interactions between food ingredients and the anticoagulant therapy.

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Review on mechanisms and interactions in concomitant use of herbs and warfarin therapy

Cited by 86 publications

References 48 publications

Common Drug Side Effects and Drug‐Drug Interactions in Elderly Adults in Primary Care

Common Drug Side Effects and Drug‐Drug Interactions in Elderly Adults in Primary Care

Efecto de Maytenus krukovii "Chuchuhuasi" en el tratamiento de osteoartrosis leve-moderada. Ensayo clínico aleatorizado doble-ciego, controlado con placebo.

Hemorrhage After Lunch?

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