Review on combining surface-enhanced Raman spectroscopy and electrochemistry for analytical applications

Moldovan, Radu-Cristian; Vereshchagina, Elizaveta; Mileńko, Karolina; Iacob, Bogdan-Cezar; Bodoki, Andreea; Fălămaș, Alexandra; Toşa, Nicoleta; Muntean, Cristina M.; Farcău, Cosmin; Bodoki, Ede

doi:10.1016/j.aca.2021.339250

Cited by 53 publications

(28 citation statements)

References 201 publications

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“…The advantage of this procedure is that it combines Raman spectroscopy with electrochemical analysis, thus offering both identification and quantification capabilities [ 32 ]. Several EC-SERS miniaturized sensors have been described in a recent review, covering quality control, diagnosis, biomedical, environmental and food safety fields [ 33 ]. A novel electrochemical roughening technique of commercial disposable electrodes of metallic surfaces such as gold and silver has been used to improve the reproducibility of the SERS substrate based on the deposition of nanostructures [ 34 , 35 , 36 , 37 ].…”

Section: Introductionmentioning

confidence: 99%

Rapid Determination of the ‘Legal Highs’ 4-MMC and 4-MEC by Spectroelectrochemistry: Simultaneous Cyclic Voltammetry and In Situ Surface-Enhanced Raman Spectroscopy

González-Hernández

Ott

Arcos‐Martínez

et al. 2021

Sensors

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The synthetic cathinones mephedrone (4-MMC) and 4-methylethcathinone (4-MEC) are two designer drugs that represent the rise and fall effect of this drug category within the stimulants market and are still available in several countries around the world. As a result, the qualitative and quantitative determination of ‘legal highs’, and their mixtures, are of great interest. This work explores for the first time the spectroelectrochemical response of these substances by coupling cyclic voltammetry (CV) with Raman spectroscopy in a portable instrument. It was found that the stimulants exhibit a voltammetric response on a gold screen-printed electrode while the surface is simultaneously electro-activated to achieve a periodic surface-enhanced Raman spectroscopy (SERS) substrate with high reproducibility. The proposed method enables a rapid and reliable determination in which both substances can be selectively analyzed through the oxidation waves of the molecules and the characteristic bands of the electrochemical SERS (EC-SERS) spectra. The feasibility and applicability of the method were assessed in simulated seized drug samples and spiked synthetic urine. This time-resolved spectroelectrochemical technique provides a cost-effective and user-friendly tool for onsite screening of synthetic stimulants in matrices with low concentration analytes for forensic applications.

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Section: Introductionmentioning

confidence: 99%

Rapid Determination of the ‘Legal Highs’ 4-MMC and 4-MEC by Spectroelectrochemistry: Simultaneous Cyclic Voltammetry and In Situ Surface-Enhanced Raman Spectroscopy

González-Hernández

Ott

Arcos‐Martínez

et al. 2021

Sensors

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“…The former occurs when the excitation laser is tuned into or near an electronic transition of the molecule that is attached on a SERS substrate. Under this condition an improvement of the conventional resonance Raman scattering of the molecule is induced by its proximity to the substrate ( López-Castaños et al, 2020 ; Moldovan et al, 2022 ). The PL-SERS arises from the coupling of certain normal modes of the adsorbate with internal resonant excitations of small metal clusters ( Román-Pérez et al, 2014 ).…”

Section: Surface Enhanced Raman Spectroscopy As a Point Of Care Techn...mentioning

confidence: 99%

A review of cardiac troponin I detection by surface enhanced Raman spectroscopy: Under the spotlight of point-of-care testing

Saviñon-Flores

Trejo

et al. 2022

Front. Chem.

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Cardiac troponin I (cTnI) is a biomarker widely related to acute myocardial infarction (AMI), one of the leading causes of death around the world. Point-of-care testing (POCT) of cTnI not only demands a short turnaround time for its detection but the highest accuracy levels to set expeditious and adequate clinical decisions. The analytical technique Surface-enhanced Raman spectroscopy (SERS) possesses several properties that tailor to the POCT format, such as its flexibility to couple with rapid assay platforms like microfluidics and paper-based immunoassays. Here, we analyze the strategies used for the detection of cTnI by SERS considering POCT requirements. From the detection ranges reported in the reviewed literature, we suggest the diseases other than AMI that could be diagnosed with this technique. For this, a section with information about cardiac and non-cardiac diseases with cTnI release, including their release kinetics or cut-off values are presented. Likewise, POCT features, the use of SERS as a POCT technique, and the biochemistry of cTnI are discussed. The information provided in this review allowed the identification of strengths and lacks of the available SERS-based point-of-care tests for cTnI and the disclosing of requirements for future assays design.

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“…Furthermore, SERS is a versatile analytical technique that can further increase the intensity of the Raman-enhancing effect by adsorbing the number of molecules on the surface of metal nanostructures [ 5 , 6 , 7 ]. So far, the SERS technique has been recognized as one of the most sensitive and promising analytical tools in the chemical, biological, environmental, and clinical fields because it can provide much structural information [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…The other is that the chemical mechanism, which belongs to the charge transfer between the molecule and the substrate surface, significantly amplifies the molecular polarization tensor and improves the Raman enhancement [ 12 , 13 , 14 ]. SERS substrates with noble metal nanostructures can be efficiently tuned for the electromagnetic mechanism by controlling their size, shape, and distribution on suitable substrates [ 9 , 15 , 16 , 17 ]. However, several problems limit the development of SERS substrates, such as low nanostructure density, uncontrolled aggregation, and uneven distribution of nanostructures [ 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Ag Nanoparticles Decorated CuO@RF Core-Shell Nanowires for High-Performance Surface-Enhanced Raman Spectroscopy Application

Chang

et al. 2022

Molecules

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Vertical-aligned CuO nanowires have been directly fabricated on Cu foil through a facile thermal oxidation process by a hotplate at 550 °C for 6 h under ambient conditions. The intermediate layer of resorcinol–formaldehyde (RF) and silver (Ag) nanoparticles can be sequentially deposited on Cu nanowires to form CuO@RF@Ag core-shell nanowires by a two-step wet chemical approach. The appropriate resorcinol weight and silver nitrate concentration can be favorable to grow the CuO@RF@Ag nanowires with higher surface-enhanced Raman scattering (SERS) enhancement for detecting rhodamine 6G (R6G) molecules. Compared with CuO@Ag nanowires grown by ion sputtering, CuO@RF@Ag nanowires exhibited a higher SERS enhancement factor of 5.33 × 108 and a lower detection limit (10−12 M) for detecting R6G molecules. This result is ascribed to the CuO@RF@Ag nanowires with higher-density hot spots and surface-active sites for enhanced high SERS enhancement, good reproducibility, and uniformity. Furthermore, the CuO@RF@Ag nanowires can also reveal a high-sensitivity SERS-active substrate for detecting amoxicillin (10−10 M) and 5-fluorouracil (10−7 M). CuO@RF@Ag nanowires exhibit a simple fabrication process, high SERS sensitivity, high reproducibility, high uniformity, and low detection limit, which are helpful for the practical application of SERS in different fields.

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Review on combining surface-enhanced Raman spectroscopy and electrochemistry for analytical applications

Cited by 53 publications

References 201 publications

Rapid Determination of the ‘Legal Highs’ 4-MMC and 4-MEC by Spectroelectrochemistry: Simultaneous Cyclic Voltammetry and In Situ Surface-Enhanced Raman Spectroscopy

Rapid Determination of the ‘Legal Highs’ 4-MMC and 4-MEC by Spectroelectrochemistry: Simultaneous Cyclic Voltammetry and In Situ Surface-Enhanced Raman Spectroscopy

A review of cardiac troponin I detection by surface enhanced Raman spectroscopy: Under the spotlight of point-of-care testing

Ag Nanoparticles Decorated CuO@RF Core-Shell Nanowires for High-Performance Surface-Enhanced Raman Spectroscopy Application

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