A review of cardiac troponin I detection by surface enhanced Raman spectroscopy: Under the spotlight of point-of-care testing

Saviñon-Flores, Anel I.; Saviñon-Flores, Fernanda; Trejo, G.; Méndez, Erika; Ţălu, Ștefan; González‐Fuentes, Miguel A.; Méndez‐Albores, Alia

doi:10.3389/fchem.2022.1017305

Cited by 10 publications

(12 citation statements)

References 242 publications

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“…UA and cTn are typical biomarkers for gout and AMI, respectively. [42][43][44][45][46][47] However, the goldstandard methods used in clinic cannot be used to give rapid results in the home. Together with a homemade centrifugal device and hand-held Raman spectrometer, the 3D-graphene/Al-AAO substrate was used to create a home detection system to rapidly detect the amount of UA and cTn in the blood of a patient.…”

Section: Resultsmentioning

confidence: 99%

A synergistic biomimetic optical structure for household health monitoring

Zhang

Ding

et al. 2023

Preprint

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A breakthrough in the performance of bionic optical structures will only be achieved if we can obtain an in-depth understanding of the synergy mechanisms operating in natural optical structures and find ways to imitate them. In this work, inspired by feline eyes, an optical structure that takes advantage of a synergistic effect that occurs between resonant and reflective structures was designed. The reflective structure consists of anodic aluminum oxide with an aluminized inner layer (Al-AAO), and the resonant structure consists of three-dimensional (3D) graphene inside, and on the surface of the Al-AAO. The synergistic effect between the reflective and resonant components leads to a Raman enhancement factor (EF) of 1.16 × 107 which is much greater than that achieved using the reflective/resonant cavities on their own. A 2-3 order of magnitude increase in sensitivity could thus be achieved when used to detect model compounds. More importantly, the optical device was further used to develop a highly-sensitive household health monitoring system. The system uses simple apparatus (homemade centrifugal device and hand-held Raman spectrometer) and rapidly produces results (detection time＜3 min). It can thus be used to give early warning of acute diseases with high risk (e.g., acute myocardial infarction). The 3D-graphene/Al-AAO substrates were also found to have good reusability and storability (9% and 7% reduction in EF after washing 30 times and 8 weeks of storage, respectively). They thus reduce detection costs (to ~$1), making them much cheaper to use than the current gold-standard methods (e.g., ~$16 for gout detection).

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Section: Resultsmentioning

confidence: 99%

A synergistic biomimetic optical structure for household health monitoring

Zhang

Ding

et al. 2023

Preprint

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“…An important advantage of modern highly sensitive troponin immunotests is the ability to detect cardiac troponin molecules in noninvasively obtained biological material (oral fluid, urine, sweat) [ 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 ]. When receiving these biomaterials, a number of advantages can be noted: the process is non-invasive, atraumatic, and painless, no specially trained medical personnel is required, and the preliminary diagnostics can be tested at home (test strips).…”

Section: Characteristics and Benefits Of Using New Highly Sensitive L...mentioning

confidence: 99%

Gender Specificities of Cardiac Troponin Serum Levels: From Formation Mechanisms to the Diagnostic Role in Case of Acute Coronary Syndrome

Chaulin

2023

Life

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Cardiac troponins T and I are the main (most sensitive and specific) laboratory indicators of myocardial cell damage. A combination of laboratory signs of myocardial cell damage (elevated levels of cardiac troponins T and I) with clinical (severe chest pain spreading to the left side of the human body) and functional (rise or depression of the ST segment, negative T wave or emergence of the Q wave according to electrocardiography and/or decrease in the contractility of myocardial areas exposed to ischemia according to echocardiography) signs of myocardial ischemia is indicative of the ischemic damage to cardiomyocytes, which is characteristic of the development of acute coronary syndrome (ACS). Today, with early diagnostic algorithms for ACS, doctors rely on the threshold levels of cardiac troponins (99th percentile) and on the dynamic changes in the serum levels over several hours (one, two, or three) from the moment of admission to the emergency department. That said, some recently approved highly sensitive methods for determining troponins T and I show variations in 99th percentile reference levels, depending on gender. To date, there are conflicting data on the role of gender specificities in the serum levels of cardiac troponins T and I in the diagnostics of ACS, and the specific mechanisms for the formation of gender differences in the serum levels of cardiac troponins T and I are unknown. The purpose of this article is to analyze the role of gender specificities in cardiac troponins T and I in the diagnostics of ACS, and to suggest the most likely mechanisms for the formation of differences in the serum levels of cardiac troponins in men and women.

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“…Moreover, HS methods for determining cTns have raised the issue of the need to take into account the gender, age and circadian characteristics of cTns concentration when using rapid algorithms for the diagnosis of acute coronary syndrome [23,24,[27][28][29][30]. Increased sensitivity has also contributed to the introduction of new data on the diagnostic capabilities of non-canonical to cardiovascular diseases biological fluids such as urine [31,32], oral fluid [33][34][35][36] and sweat [36] creating the foundation for further research on non-invasive diagnostic methods.…”

Section: Cardiac Troponins As Early Biomarkers Of Myocardial Cell Damagementioning

confidence: 99%

Cardiotoxicity as a Possible Side Effect of Statins

Chaulin¹

2023

Rev. Cardiovasc. Med.

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According to current views, statins have a wide range of beneficial effects (lipid and non-lipid) on the cardiovascular system, so they are one of the most commonly used drugs for the prevention and management of patients with cardiovascular diseases. However, it is important to note that information about many beneficial effects of statins is contradictory. In addition, a number of side effects of statins, in particular, myotoxicity, hepatotoxicity, diabetogenic property, etc., may limit the possibility of using statins or even force doctors to cancel these drugs. Also, some concerns are caused by recent studies reporting cardiotoxicity of statins and increased serum concentrations of biomarkers of myocardial damage (highly sensitive cardiac troponins (hs-cTns)) in patients taking statins. This article discusses in detail the possible mechanisms of cardiotoxicity of statins and outlines the directions for further research in this area.

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A review of cardiac troponin I detection by surface enhanced Raman spectroscopy: Under the spotlight of point-of-care testing

Cited by 10 publications

References 242 publications

A synergistic biomimetic optical structure for household health monitoring

A synergistic biomimetic optical structure for household health monitoring

Gender Specificities of Cardiac Troponin Serum Levels: From Formation Mechanisms to the Diagnostic Role in Case of Acute Coronary Syndrome

Cardiotoxicity as a Possible Side Effect of Statins

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