Review of twelve West Africa medicinal plants: Active phytochemical combinations in direct biochemically wound healing process

Edefia, Akpalo; Tété‐Bénissan, Amivi; Awaga, Kwami Lumo; Akpagana, Koffi

doi:10.5897/jmpr2015.5849

Cited by 7 publications

(4 citation statements)

References 50 publications

(55 reference statements)

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“…This study has shown that S. longiflora possess some analgesic properties using the force gauge machine on experimental cutaneous wounds which was due to the flavonoids component of the secondary metabolites as described by Akpalo et al (2015), Fakhim et al (2015) and Christian et al (2016). Flavonoids are free radical scavengers due to their high reactivity as hydrogen or electron donors.…”

Section: Analgesic Propertiesmentioning

confidence: 69%

Analgesic effect of Sansevieria longiflora (Sim) water extract and xylocaine cream on surgical wound incision in rats

Kilani

Hassan

Fadason

et al. 2020

Bangladesh J. Sci. Ind. Res.

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Analgesic effect of Sansevieria longiflora (S. longiflora) on surgically created wound was studied. Phytochemical screening of the crude water extracts was carried out following standard procedures. Sansevieria longiflora leaves was heated and the sap was squeezed into a sample bottle to be used as it was traditional believed. Its water extract was also prepared following standard procedure. Four (4) albino rats consisting of 2 males and 2 females were used for the study. One centimeter full thickness skin incision was created on 4 different locations at the dorsal region of each rat under anaesthesia. Each of the 4 wounds created was topically treated once daily with S. longiflora sap (E), S. longiflora water extract (F), Physiological saline solution (C) and xylocaine cream (G). The treatment regimen was rotated in a clockwise direction on each rat. Pain perception was evaluated with an algometer at 6:00 GMT (morning) and 18:00 GMT (evening) from day 1 post surgery for 5 days. The phytochemical studies revealed that S. longiflora contains carbohydrates, glycoside, saponins, steroids, triterpenes, flavonoids, alkaloids and tannins. Day1 after the surgery, the mean morning value of force (N) required to elicit pain in xylocaine treated wounds (5.2 ± 0.79) were significantly higher (p<0.001) than that of physiological saline solution (2.8 ± 0.29) whereas, not different from that of S. longiflora sap (4.48 ± 0.57) and water extract (4.2 ± 0.6). Similarly, on the day 5 after the surgery, the mean morning value of force (N) required to elicit pain in xylocaine treated wounds were significantly higher (p<0.0001) than that of physiological saline solution (PSS) treated wounds and not different from that of S. longiflora sap and water extract. This showed that S. longiflora sap and water extract possess analgesic effect on incisional wounds. This study serves as a preliminary study on this plant towards searching for potent analgesics that could be used for procedural pain management. Bangladesh J. Sci. Ind. Res.55(2), 99-106, 2020

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Section: Analgesic Propertiesmentioning

confidence: 69%

Analgesic effect of Sansevieria longiflora (Sim) water extract and xylocaine cream on surgical wound incision in rats

Kilani

Hassan

Fadason

et al. 2020

Bangladesh J. Sci. Ind. Res.

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“…Alkaloids, flavonoids and saponins are present as well as triterpenes and glycosides [79,88]. The leaf extract of M. excelsa is reported to be safe in rodents [79,89,90].…”

Section: Milicia Excelsa (Welw) CC Bergmentioning

confidence: 99%

Medicinal Plants Used as Galactagogues

Bekoe¹,

Kitcher²,

Gyima³

et al. 2019

Pharmacognosy - Medicinal Plants

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The recommended diet for human infants within the first 6 months of life is breast milk. No other natural or artificial formulation has been able to match up to this gold standard. Mothers who have attempted to pursue exclusive breastfeeding can, however, attest to numerous nutritional and non-nutritional challenges mainly resulting in insufficient milk production (hypogalactia) or the absence of milk production (agalactia). There are very few and officially recommended orthodox drugs to increase lactation. The most widely used galactagogues being chlorpromazine, sulpiride, metoclopramide and domperidone are associated with very high incidences of unpleasant side effects including their extra-pyramidal effects in both mother and infant. There is therefore a need to keep searching for more acceptable galactagogues. This section reviews current literature on medicinal plants used within the local Ghanaian community to enhance lactation. Various electronic databases such as PubMed, Science Direct, SciFinder and Google Scholar as well as published books on Ghanaian medicinal plants were searched. A total of 22 plants belonging to 13 families were reviewed with regards to their medicinal values, information on lactation and toxicity.

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“…The process of wound healing is promoted by several herbal extracts, which are composed of active agents like triterpenes, alkaloids, flavonoids, tannins, saponins, anthraquinones, and other biomolecules (Akpalo et al, 2015) . Tannins act as free radical scavengers.…”

Section: Introductionmentioning

confidence: 99%

“…The antioxidant and anti-inflammatory activities of flavonoids were believed to be one of the important mechanisms in wound healing and in the presence of tannin, it improved the regeneration and organization of the new tissue and hastened the wound healing process. Indeed, biochemically wound healing process is promoted by active agents which compose aqueous and or alcohol herbal extracts and those components act synergistically (Akpalo et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Wound healing biomolecules present in four proposed soft aqueous extractions of <i>Ageratum conyzoides</i> Linn

Akpalo¹,

Saloufou²,

Eloh³

et al. 2020

Int. J. Bio. Chem. Sci

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Biochemically wound healing process is promoted by active agents which compose aqueous and alcohol herbal extracts and those components act synergistically. We propose in this study four methods of soft aqueous extraction (A, B, C, D) of Ageratum conyzoides Linn. leaves, a well-known west african plant for its wound healing properties. Our main objective was to know which of the extraction methods would allow us to obtain specifically tannins and flavonoids. We also investigated which types of flavonoids extracted could inhibit serine proteases like thrombin or serine proteases present in bacterial and then being bactericide. Ageratum conyzoides Linn. samples were collected in the beginning of the raining period in May 2019 in two regions of Togo. After aqueous extractions, TLC and HPLC-ESI+-QTOF analysis were done. Chromatographic fingerprints obtained were quite similar for the four extracts investigated. However, additional spots with different colors appeared for the B extract. Flavonoids were revealed by the numerous colors of spots observed on the chromatograms. Superposing HPLC-ESI+-QTOF chromatographic profiles of the four extracts, we deduced that our proposed extraction methods lead to same chemical compounds but B extract contained higher concentrations of later substances. Identified molecules belong to terpernoids and flavonoids classes.Keywords: Ageratum Conyzoides Linn., Aqueous extractions, Biomolecules, Wound healing.

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Review of twelve West Africa medicinal plants: Active phytochemical combinations in direct biochemically wound healing process

Cited by 7 publications

References 50 publications

Analgesic effect of Sansevieria longiflora (Sim) water extract and xylocaine cream on surgical wound incision in rats

Analgesic effect of Sansevieria longiflora (Sim) water extract and xylocaine cream on surgical wound incision in rats

Medicinal Plants Used as Galactagogues

Wound healing biomolecules present in four proposed soft aqueous extractions of <i>Ageratum conyzoides</i> Linn

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