Review of tissue simulating phantoms with controllable optical, mechanical and structural properties for use in optical coherence tomography

Lamouche, Guy; Kennedy, Brendan F.; Kennedy, Kelsey M.; Bisaillon, Charles-Etienne; Curatolo, Andrea; Campbell, Gordon; Pazos, Valerie; Sampson, David D.

doi:10.1364/boe.3.001381

Cited by 180 publications

(141 citation statements)

References 70 publications

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“…5.2). Previous reviews of OCT focused on advanced screening in the fields of primary care, 53 microscopy, 54 rapid tissue screening, 55 phantoms, 56 high speed, 57 and translational research, 58 while recent application-specific OCT reviews covered ophthalmology, [59][60][61] cardiology, [62][63][64][65][66] dermatology, [67][68][69][70] novel applications in pulmonary medicine, 71 cancer, 72 and optical coherence elastography, 73 as well as OCT post-and signal processing. 74,75 This review focuses on high-speed technology (SS light technology and parallelization of OCT detection), label-free angiography, and multimodal OCT.…”

Section: Introductionmentioning

confidence: 99%

Optical coherence tomography today: speed, contrast, and multimodality

Drexler¹,

Li²,

Kumar³

et al. 2014

J. Biomed. Opt

403

264

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Abstract. In the last 25 years, optical coherence tomography (OCT) has advanced to be one of the most innovative and most successful translational optical imaging techniques, achieving substantial economic impact as well as clinical acceptance. This is largely owing to the resolution improvements by a factor of 10 to the submicron regime and to the imaging speed increase by more than half a million times to more than 5 million A-scans per second, with the latter one accomplished by the state-of-the-art swept source laser technologies that are reviewed in this article. In addition, parallelization of OCT detection, such as line-field and full-field OCT, has shortened the acquisition time even further by establishing quasi-akinetic scanning. Besides the technical improvements, several functional and contrast-enhancing OCT applications have been investigated, among which the label-free angiography shows great potential for future studies. Finally, various multimodal imaging modalities with OCT incorporated are reviewed, in that these multimodal implementations can synergistically compensate for the fundamental limitations of OCT when it is used alone. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Section: Introductionmentioning

confidence: 99%

Optical coherence tomography today: speed, contrast, and multimodality

Drexler¹,

Li²,

Kumar³

et al. 2014

J. Biomed. Opt

403

264

View full text Add to dashboard Cite

show abstract

“…However, liquid phantoms are among the most commonly used phantoms in biophotonic studies [5][6][7]. Liquid optical phantoms construction is simple and straightforward.…”

Section: Introductionmentioning

confidence: 99%

Broadband spectroscopy for characterization of tissue-like phantom optical properties

Shahin

Bachir

2017

Polish Journal of Medical Physics and Engineering

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Optical phantoms are widely used for evaluating the performance of biomedical optical modalities, and hence, absorbing and scattering materials are required for the construction of optical phantoms. Towards that aim, new readily available and inexpensive black Ink (Parker) as a simulating absorber as well as Intralipid 20% as a simulating scatterer are thoroughly investigated. Broadband Transmittance and Diffuse reflectance spectroscopic measurements were performed in the visible range 400 -700 nm. Optical properties of the phantom materials are determined. Analytical expressions for absorption and scattering coefficient related to the concentrations and wavelength of the Parker ink and Intralipid are also presented and discussed. The results show nonlinear trend in the absorption coefficient of Parker ink over the examined visible spectral range. Furthermore, Intralipid scattering coefficient variation across the mentioned spectral range shows a tissue-like scattering trend. The findings demonstrate the capability of the broadband transmission and diffuse reflectance for characterizing tissue-like phantom materials in the examined spectral range.

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“…For this purpose, these mimicked body parts should be modeled with equivalent tissue phantoms. Phantoms for optical studies have already fulfilled the requirements of stability, biological compatibility, and replicated the representative values of specific optical properties of the real tissue [1][2][3][4][5][6]. These requirements have now swayed into generating realistic physiological structures, that permits an increasing complexity of optical imaging studies on tissue phantoms [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Preparation of a skin equivalent phantom with interior micron-scale vessel structures for optical imaging experiments

Chen

Klämpfl

Knipfer

et al. 2014

Biomed. Opt. Express

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Abstract:A popular alternative of preparing multilayer or microfluidic chip based phantoms could have helped to simulate the subsurface vascular network, but brought inevitable problems. In this work, we describe the preparation method of a single layer skin equivalent tissue phantom containing interior vessel channels, which mimick the superficial microvascular structure. The fabrication method does not disturb the optical properties of the turbiding matrix material. The diameter of the channels reaches a value of 50 µm. The size, as well as the geometry of the generated vessel structures are investigated by using the SD-OCT system. Our preliminary results confirm that fabrication of such a phantom is achievable and reproducible. Prospectively, this phantom is used to calibrate the optical angiographic imaging approaches.

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Review of tissue simulating phantoms with controllable optical, mechanical and structural properties for use in optical coherence tomography

Cited by 180 publications

References 70 publications

Optical coherence tomography today: speed, contrast, and multimodality

Optical coherence tomography today: speed, contrast, and multimodality

Broadband spectroscopy for characterization of tissue-like phantom optical properties

Preparation of a skin equivalent phantom with interior micron-scale vessel structures for optical imaging experiments

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