Review of the existing maximum residue levels for quizalofop‐P‐ethyl, quizalofop‐P‐tefuryl and propaquizafop according to Article 12 of Regulation (EC) No 396/2005

Brancato, Alba; Brocca, Daniela; Lentdecker, Chloé De; Erdős, Zoltán; Ferreira, Lucien; Greco, Luna; Jarrah, Samira; Kardassi, Dimitra; Leuschner, Renata; Lythgo, Christopher; Medina, Paula; Miron, Ileana; Molnár, Tünde; Nougadère, Alexandre; Pedersen, Ragnor; Reich, Hermine; Sacchi, Angela; Santos, Miguel; Stanek, Alois; Sturma, Juergen; Tarazona, José; Theobald, Anne; Vagenende, Bénédicte; Verani, Alessia; Villamar‐Bouza, Laura

doi:10.2903/j.efsa.2017.5050

Cited by 8 publications

(67 citation statements)

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“…The review of existing MRLs according to Article 12 of Regulation (EC) No 396/2005 (MRL review) has been finalised for all quizalofop ester variants (propaquizafop, quizalofop‐P‐ethyl and quizalofop‐P‐tefuryl) (EFSA, ). In this reasoned opinion, EFSA also recommended a modification of the residue definition for enforcement (current residue definition: ‘propaquizafop’; proposed new residue definition: ‘quizalofop (sum of quizalofop, its salts, its esters (including propaquizafop) and its conjugates, expressed as quizalofop (any ratio of constituent isomers)’).…”

Section: Assessmentmentioning

confidence: 99%

“…EFSA based its assessment on the evaluation report submitted by the EMS (Italy, ), the draft assessment report (DAR) (Italy, ) prepared under Council Directive 91/414/EEC, the conclusion on the peer review of the pesticide risk assessment of the active substance propaquizafop and quizalofop‐p (EFSA, ,b), as well as the conclusions from the previous EFSA opinion on the review of the existing for quizalofop‐P‐ethyl, quizalofop‐P‐tefuryl and propaquizafop (EFSA, ).…”

Section: Assessmentmentioning

confidence: 99%

“…The metabolism of propaquizafop in leafy, root and pulses/oilseeds crop groups was evaluated in the framework of the peer review under Directive 91/414/EEC in studies with 14 C‐propaquizafop either labelled on the phenyl or the quinoxaline moieties (EFSA, ).…”

Section: Residues In Plantsmentioning

confidence: 99%

“…The metabolism of propaquizafop in rotational crops was investigated in sugar beet, spinach and wheat sown at plant‐back intervals (PBIs) of 30, 120 and 270 days after harvest of a primary crop (soybeans) treated twice with propaquizafop at 280 g/ha (EFSA, ).…”

Section: Residues In Plantsmentioning

confidence: 99%

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Modification of the existing maximum residue levels for quizalofop (resulting from the use of propaquizafop) in lettuces and salad plants

Anastassiadou¹,

Brancato²,

Cabrera³

et al. 2019

EFS2

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In accordance with Article 6 of Regulation (EC) No 396/2005, the applicant Adama Agan Ltd submitted a request to the competent national authority in Italy to modify the existing maximum residue levels (MRLs) for propaquizafop/quizalofop in lettuces and salad plants to accommodate the intended SEU use of propaquizafop. The data submitted in support of the request were found to be sufficient to derive MRL proposals of 0.15 mg/kg for the intended SEU use of propaquizafop for the crops belonging to the crop group of lettuces and salad plants. The MRL proposals are expressed for a common residue definition that covers quizalofop and propaquizafop. Since the EU MRL is set at a higher level of 0.20 mg/kg, no modification of the MRL is currently required for the intended use. Adequate analytical methods for enforcement are available to control the residues of propaquizafop, expressed as quizalofop, in plant matrices under consideration. Based on the risk assessment results, EFSA concluded that the long-term and short-term intake of residues occurring in food from the existing uses of quizalofop-P-ethyl, quizalofop-P-tefuryl and propaquizafop and from the intended use of propaquizafop on lettuces and other salad plants, is unlikely to present a risk to consumer health.

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Section: Assessmentmentioning

confidence: 99%

Section: Assessmentmentioning

confidence: 99%

Section: Residues In Plantsmentioning

confidence: 99%

Section: Residues In Plantsmentioning

confidence: 99%

See 2 more Smart Citations

Modification of the existing maximum residue levels for quizalofop (resulting from the use of propaquizafop) in lettuces and salad plants

Anastassiadou¹,

Brancato²,

Cabrera³

et al. 2019

EFS2

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“…For this application, the data requirements established in Regulation (EU) No 544/2011 5 and the guidance documents applicable at the date of submission of the application to the EMS are applicable (European Commission, 1997a-g, 2000, 2010a,b, 2017OECD, 2011OECD, , 2013 A selected list of end points of the studies assessed by EFSA in the framework of this MRL application, including the end points of relevant studies assessed previously, are presented in Appendix B.…”

Section: Assessmentmentioning

confidence: 99%

Setting of import tolerance for quizalofop‐P‐ethyl in genetically modified maize

Brancato¹,

Brocca²,

Cabrera³

et al. 2018

EFS2

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In accordance with Article 6 of Regulation (EC) No 396/2005, the applicant Dow AgroSciences submitted a request to the competent national authority in Finland, to set an import tolerance for quizalofop-P-ethyl in grain from genetically modified maize containing aad-1 gene. The data submitted in support of the request were found to be sufficient to derive a maximum residue level (MRL) proposal for quizalofop-P-ethyl maize grain. Adequate analytical methods for enforcement are available to control the residues of quizalofop-P-ethyl in maize grain. Based on the risk assessment results, EFSA concluded that the authorised use of quizalofop-P-ethyl on genetically modified maize containing aad-1 gene and the subsequent import of maize grain in Europe will not result in a consumer exposure exceeding the toxicological reference value and therefore is unlikely to pose a risk to consumers' health. , 2018. Reasoned opinion on the setting of import tolerance for quizalofop-P-ethyl in genetically modified maize. EFSA Journal 2018;16(3):5250, 23 pp. https://doi. SummaryIn accordance with Article 6 of Regulation (EC) No 396/2005, Dow AgroSciences submitted an application to the competent national authority in Finland (evaluating Member State, EMS), to set an import tolerance for the active substance quizalofop-P-ethyl in genetically modified (GM) maize (i.e. maize varieties expressing the AAD-1 protein that conveys resistance to 2,4-D, MCPA and aryloxyphenoxypropionate (AOPP) herbicides (R-isomers of dichlorprop, cyhalofop and quizalofop). The EMS drafted an evaluation report in accordance with Article quizalofop-P-ethyl, 8 of Regulation (EC) No 396/2005, which was submitted to the European Commission and forwarded to the European Food Safety Authority (EFSA) on 25 January 2018. The EMS proposed to establish an maximum residue level (MRL) for GM maize imported from Canada, at the level of 0.02 mg/kg.EFSA assessed the application and the evaluation report as required by Article 10 of the MRL regulation.Based on the conclusions derived by EFSA in the framework of Directive 91/414/EEC and the MRL Review under Article 12 of Regulation (EC) No 396/2005, and the new data submitted by the EMS in the MRL application, the following conclusions are derived.The metabolism of quizalofop-P-ethyl has been investigated following foliar applications in fruit crops, root crops and pulses/oilseeds. In the framework of the current application, a new metabolism study was submitted investigating the nature of quizalofop-P-ethyl in GM maize, containing the aryloxyalkanoate dioxygenase (aad-1) gene. At an application rate slightly above the authorised use rate, the total radioactive residue (TRR) in maize grain and cob was very low and thus not further characterised. European Food Safety Authority (EFSA) concludes that the metabolism of quizalofop-P-ethyl in GM maize grain is sufficiently investigated, indicating very low residues in GM maize grain when treated with quizalofop-P-ethyl at the rate tested. Additional metabolism studies are currently not...

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Evaluation of bioassay methods to screen winter wheat for quizalofop herbicide tolerance

2023

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Herbicide-resistant wheat cultivars are an effective tool in controlling weeds. The CoAxium wheat (Triticum aestivum L.) cultivar conferring tolerance to quizalofopp-ethyl herbicide was developed along with a bioassay to quantify traited seeds in a sample. The objectives of this study were to (1) compare a current seed soaking (SS) method with substrate imbibition (SI) method in detecting AXigen trait in two genotypes, CO14A050 (homozygous resistant-A/D genomes) and CO14A136 (homozygous resistant-B/D genomes), and (2) develop criteria to distinguish between trait and nontrait seedlings based on chemical injury using standard germination, linear length, and dry matter content tests. Quizalofop doses 0.0, 3.0, 4.0, and 5.0 μM were used in both methods. A soft white winter wheat, Bobtail, was used as a susceptible control. Using SS, 96% of Bobtail seedlings were classified as nontrait at 3.0 μM and 100% at 4.0 and 5.0 μM; however, using SI, only 1.0%-6.0% showed chemical injury and were classified as nontrait. The SI did not differentiate between trait and nontrait seedlings at any dose. At 5 μM, CO14A136 showed significant chemical injury (26%) compared to CO14A050 (1%). A greenhouse dose-response study confirmed that CO14A136 conferred lower tolerance to quizalofop than CO14A050. The SS method at 5 μM was suitable for identifying trait and nontrait seeds. It is recommended that both root and shoot structure should be considered in evaluating trait and nontrait seedlings, not only roots like the current protocol.

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Review of the existing maximum residue levels for quizalofop‐P‐ethyl, quizalofop‐P‐tefuryl and propaquizafop according to Article 12 of Regulation (EC) No 396/2005

Cited by 8 publications

References 1 publication

Modification of the existing maximum residue levels for quizalofop (resulting from the use of propaquizafop) in lettuces and salad plants

Modification of the existing maximum residue levels for quizalofop (resulting from the use of propaquizafop) in lettuces and salad plants

Setting of import tolerance for quizalofop‐P‐ethyl in genetically modified maize

Evaluation of bioassay methods to screen winter wheat for quizalofop herbicide tolerance

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