Review of the Effects and Mechanism of Curcumin in the Treatment of Inflammatory Bowel Disease

Lin, Yuan; Liu, Heng-Jian; Bu, Lingling; Chen, Chen; Ye, Xiaofeng

doi:10.3389/fphar.2022.908077

Cited by 11 publications

(8 citation statements)

References 66 publications

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“…Intestinal epithelial cells detect bacteria and other microorganisms through TLR4 and other pattern recognition receptors (PRR) expressed on immune cells, such as macrophages and DC cells [99]. These receptors identify pathogen-associated molecular patterns (PAMPs) on microorganisms, resulting in a normalized immune response [19].…”

Section: Immune Systemmentioning

confidence: 99%

The Modulatory Effects of Curcumin on the Gut Microbiota: A Potential Strategy for Disease Treatment and Health Promotion

Zhu,

2024

Microorganisms

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Curcumin (CUR) is a lipophilic natural polyphenol that can be isolated from the rhizome of turmeric. Studies have proposed that CUR possesses a variety of biological activities. Due to its anti-inflammatory and antioxidant properties, CUR shows promise in the treatment of inflammatory bowel disease, while its anti-obesity effects make it a potential therapeutic agent in the management of obesity. In addition, curcumin’s ability to prevent atherosclerosis and its cardiovascular benefits further expand its potential application in the treatment of cardiovascular disease. Nevertheless, owing to the limited bioavailability of CUR, it is difficult to validate its specific mechanism of action in the treatment of diseases. However, the restricted bioavailability of CUR makes it challenging to confirm its precise mode of action in disease treatment. Recent research indicates that the oral intake of curcumin may lead to elevated levels of residual curcumin in the gastrointestinal system, hinting at curcumin’s potential to directly influence gut microbiota. Furthermore, the ecological dysregulation of the gut microbiota has been shown to be critical in the pathogenesis of human diseases. This review summarizes the impact of gut dysbiosis on host health and the various ways in which curcumin modulates dysbiosis and ameliorates various diseases caused by it through the administration of curcumin.

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Section: Immune Systemmentioning

confidence: 99%

The Modulatory Effects of Curcumin on the Gut Microbiota: A Potential Strategy for Disease Treatment and Health Promotion

Zhu,

2024

Microorganisms

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“…Antioxidant balance is also regulated by curcumin in rats with UC by lowering both colonic MPO activity and total NO content as well as increasing colonic GST activity and GSH contents when administered prior to the DSS challenge ( 154 ). Curcumin has been shown to decrease OS markers MPO and MDA levels and cell apoptosis in different animal models of colitis ( 155 – 158 ) ( Supplementary Table 1 ).…”

Section: Role Of Antioxidants For Ibd-related Therapeutic Application...mentioning

confidence: 99%

Oxidative stress, hormones, and effects of natural antioxidants on intestinal inflammation in inflammatory bowel disease

Sahoo,

Heilmann,

Paital

et al. 2023

Front. Endocrinol.

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Inflammatory bowel disease (IBD) is a chronic, relapsing gastrointestinal (GI) disorder characterized by intestinal inflammation. The etiology of IBD is multifactorial and results from a complex interplay between mucosal immunity, environmental factors, and host genetics. Future therapeutics for GI disorders, including IBD, that are driven by oxidative stress require a greater understanding of the cellular and molecular mechanisms mediated by reactive oxygen species (ROS). In the GI tract, oxidative stressors include infections and pro-inflammatory responses, which boost ROS generation by promoting the production of pro-inflammatory cytokines. Nuclear factor kappa B (NF-κB) and nuclear factor erythroid 2–related factor 2 (Nrf2) represent two important signaling pathways in intestinal immune cells that regulate numerous physiological processes, including anti-inflammatory and antioxidant activities. Natural antioxidant compounds exhibit ROS scavenging and increase antioxidant defense capacity to inhibit pro-oxidative enzymes, which may be useful in IBD treatment. In this review, we discuss various polyphenolic substances (such as resveratrol, curcumin, quercetin, green tea flavonoids, caffeic acid phenethyl ester, luteolin, xanthohumol, genistein, alpinetin, proanthocyanidins, anthocyanins, silymarin), phenolic compounds including thymol, alkaloids such as berberine, storage polysaccharides such as tamarind xyloglucan, and other phytochemicals represented by isothiocyanate sulforaphane and food/spices (such as ginger, flaxseed oil), as well as antioxidant hormones like melatonin that target cellular signaling pathways to reduce intestinal inflammation occurring with IBD.

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“…Despite its unfavorable pharmacokinetic characteristics, growing evidence has shown that CUR has numerous pharmacological properties, including antimicrobial [ 76 ], antiviral [ 77 ], antifungal [ 78 ], antioxidant [ 79 ], anti-inflammatory [ 80 ], and also anti-tumoral properties [ 81 ]. In particular, CUR represents a promising phytochemical in the anti-cancer field to be used alone or combined with other drugs through different pathways ( Figure 2 ).…”

Section: Plant-derived Bioactive Compoundsmentioning

confidence: 99%

Resveratrol, Epigallocatechin Gallate and Curcumin for Cancer Therapy: Challenges from Their Pro-Apoptotic Properties

Chimento

D’Amico

Luca

et al. 2023

Life

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Plant-derived bioactive compounds are gaining wide attention for their multiple health-promoting activities and in particular for their anti-cancer properties. Several studies have highlighted how they can prevent cancer initiation and progression, improve the effectiveness of chemotherapy, and, in some cases, limit some of the side effects of chemotherapy agents. In this paper, we provide an update of the literature on the anti-cancer effects of three extensively studied plant-derived compounds, namely resveratrol, epigallocatechin gallate, and curcumin, with a special focus on the anti-cancer molecular mechanisms inducing apoptosis in the major types of cancers globally.

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Review of the Effects and Mechanism of Curcumin in the Treatment of Inflammatory Bowel Disease

Cited by 11 publications

References 66 publications

The Modulatory Effects of Curcumin on the Gut Microbiota: A Potential Strategy for Disease Treatment and Health Promotion

The Modulatory Effects of Curcumin on the Gut Microbiota: A Potential Strategy for Disease Treatment and Health Promotion

Oxidative stress, hormones, and effects of natural antioxidants on intestinal inflammation in inflammatory bowel disease

Resveratrol, Epigallocatechin Gallate and Curcumin for Cancer Therapy: Challenges from Their Pro-Apoptotic Properties

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