The Modulatory Effects of Curcumin on the Gut Microbiota: A Potential Strategy for Disease Treatment and Health Promotion

Abstract

Curcumin (CUR) is a lipophilic natural polyphenol that can be isolated from the rhizome of turmeric. Studies have proposed that CUR possesses a variety of biological activities. Due to its anti-inflammatory and antioxidant properties, CUR shows promise in the treatment of inflammatory bowel disease, while its anti-obesity effects make it a potential therapeutic agent in the management of obesity. In addition, curcumin’s ability to prevent atherosclerosis and its cardiovascular benefits further expand its potential application in the treatment of cardiovascular disease. Nevertheless, owing to the limited bioavailability of CUR, it is difficult to validate its specific mechanism of action in the treatment of diseases. However, the restricted bioavailability of CUR makes it challenging to confirm its precise mode of action in disease treatment. Recent research indicates that the oral intake of curcumin may lead to elevated levels of residual curcumin in the gastrointestinal system, hinting at curcumin’s potential to directly influence gut microbiota. Furthermore, the ecological dysregulation of the gut microbiota has been shown to be critical in the pathogenesis of human diseases. This review summarizes the impact of gut dysbiosis on host health and the various ways in which curcumin modulates dysbiosis and ameliorates various diseases caused by it through the administration of curcumin.

Structural Variances in Curcumin Degradants: Impact on Obesity in Mice

“…In addition to its potential anticancer properties, numerous reviews suggest that curcumin can help ameliorate obesity through multiple mechanisms. 17 These include maintaining redox balance, 18 reducing inflammation, 19 modulating gut microbiota, 20 inhibiting adipogenesis, 21 stimulating energy expenditure, 22 and regulating lipid metabolism. 23 Furthermore, our previous study showed that the curcumin degradant, FER, exhibited an anticancer effect, but its potential antiobesity effect has not been discussed.…”