Review of the Effectiveness of Capsaicin for Painful Cutaneous Disorders and Neural Dysfunction

Hautkappe, Martin; Roizen, Michael F.; Toledano, Alicia Y.; Roth, Steven; Jeffries, Jane A.; Ostermeier, Andreas M.

doi:10.1097/00002508-199806000-00003

Cited by 83 publications

(48 citation statements)

References 63 publications

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“…This process is referred to as desensitization and has been exploited for its therapeutic potential. In effect, capsaicin-containing creams have been in clinical use for many years to relieve painful conditions such as diabetic neuropathy (33). Capsaicin is the key ingredient in the experimental drug Adlea (ALRGX-4975; Anesiva, Inc.), which is in phase III trials as a long-acting analgesic to treat postsurgical and osteoarthritis pain for weeks to months after a single injection to the site of pain (34).…”

Section: The Paradox Of Topical Application Of Capsaicinmentioning

confidence: 99%

“…Topical capsaicin has been suggested as an effective pain management adjunct for rheumatoid arthritis, osteoarthritis, neuralgias, diabetic neuropathy, and other conditions including neural dysfunction, inflammation, and painful or itching cutaneous disorders resulting from surgery, injury, or tumors (33). However, even in this arena, evidence for the effectiveness or safety of capsaicin use in pain relief is controversial.…”

Section: The Paradox Of Topical Application Of Capsaicinmentioning

confidence: 99%

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The Two Faces of Capsaicin

2011

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Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide) is the principal pungent component in hot peppers, including red chili peppers, jalapeños, and habaneros. Consumed worldwide, capsaicin has a long and convoluted history of controversy about whether its consumption or topical application is entirely safe. Conflicting epidemiologic data and basic research study results suggest that capsaicin can act as a carcinogen or as a cancer preventive agent. Capsaicin is unique among naturally occurring irritant compounds because the initial neuronal excitation evoked is followed by a long-lasting refractory period, during which the previously excited neurons are no longer responsive to a broad range of stimuli. This process is referred to as desensitization and has been exploited for its therapeutic potential. Capsaicin-containing creams have been in clinical use for many years to relieve a variety of painful conditions. However, their effectiveness in pain relief is also highly debated and some adverse side effects have been reported. We have found that chronic, long-term topical application of capsaicin increased skin carcinogenesis in mice treated with a tumor promoter. These results might imply that caution should be exercised when using capsaicin-containing topical applications in the presence of a tumor promoter, such as, for example, sunlight. Cancer Res; 71(8);

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Section: The Paradox Of Topical Application Of Capsaicinmentioning

confidence: 99%

Section: The Paradox Of Topical Application Of Capsaicinmentioning

confidence: 99%

The Two Faces of Capsaicin

2011

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“…Levels of neuropeptides have been shown to be increased in samples of synovial fluid from patients with rheumatoid arthritis (11), and the ligation of sensory nerves in experimental joint inflammation is associated with a beneficial effect (12), providing evidence for involvement of sensory nerve activation in arthritis. Indeed, continued topical treatment with capsaicin has been shown to be beneficial in patients with hand osteoarthritis (13), and capsaicin creams are marketed for the alleviation of pain in diseases including both osteoarthritis and rheumatoid arthritis (14). There is evidence from rodent studies that TRPV1 activation can influence pathophysiologic events in arthritis.…”

Section: 05) In Trpv1mentioning

confidence: 99%

Involvement of transient receptor potential vanilloid 1 in the vascular and hyperalgesic components of joint inflammation

Keeble¹,

Russell²,

Curtis³

et al. 2005

Arthritis & Rheumatism

154

117

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Objective. To investigate the endogenous involvement of transient receptor potential vanilloid 1 (TRPV1) in a model of knee joint inflammation in the mouse.Methods. Following characterization of wild-type (WT) and TRPV1-knockout mice, inflammation was induced via intraarticular (IA) injection of Freund's complete adjuvant (CFA). Knee swelling was assessed as diameter, and inflammatory heat hyperalgesia was determined using the Hargreaves technique, for up to 3 weeks. At 18 hours, acute hyperpermeability was measured with 125 I-albumin, and cytokines and myeloperoxidase activity, a marker of neutrophils, were assayed in synovial fluid extracts. The possibility that exogenous tumor necrosis factor ␣ (TNF␣) was involved in influencing TRPV1 activation was investigated in separate experiments.Results. Increased levels of knee swelling, hyperpermeability, leukocyte accumulation, and TNF␣ were found in WT mice 18 hours after IA CFA treatment compared with saline treatment. Significantly less knee swelling and hyperpermeability were found in TRPV1 ؊/؊ mice, but leukocyte accumulation and TNF␣ levels were similar in WT and TRPV1 ؊/؊ mice. Knee swelling in response to CFA remained significantly higher for a longer period in WT mice compared with TRPV1 ؊/؊ mice, with thermal hyperalgesic sensitivity observed at 24 hours and at 1 week in WT, but not TRPV1 ؊/؊ , mice. Knee swelling was attenuated (P < 0.05) in TRPV1 ؊/؊ compared with WT mice 4 hours after IA administration of TNF␣.Conclusion. Our findings indicate that TRPV1 has a role in acute and chronic inflammation in the mouse knee joint. Thus, selective antagonism of TRPV1 should be considered as a potential target for treatment of acute and chronic joint inflammation.

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“…6 Some capsaicin containing creams are used for the treatment of painful conditions such as long-term neuropathic pain in cancer patients 7 and diabetic neuropathy. 8 The quantity of active compounds depends on several factors such as intra species variability, environmental conditions, geographical variations, harvesting and storage time and extraction methods. 9 Marker profiling and standardization of medicinal plants can help in finding an optimum concentration of bioactive compounds present in herbal drugs and thus ensures it quality.…”

Section: Introductionmentioning

confidence: 99%

Validation of Capsaicin in Indian Capsicum Species Through RP-HPLC

Nag¹,

Chanda²,

Biswas³

et al. 2017

IJPER

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Capsaicin is a pungent capsacinoid which differs in capsicum fruit within the species and the cultivars due to its topographical diversity. Here, a comparative estimation of capsaicin in seven varieties of capsicum has been performed by RP-HPLC method. The method was carried out in reverse phase C 18 column using acetonitrile and water (1% acetic acid) as mobile phase (65:35 v/v), at the flow rate of 1ml/min. The λmax was detected at 230 nm. The calibration curves were linear in the concentration range of 1-80 µg/ml. The comparative study revealed that the capsaicin content was highest (3.12% w/w) in Capsicum annuum Cayenne whereas Capsicum cardenasii contains the lowest (0.85% w/w). The % RSD of precision and recovery was found to be < 2%, which confirms high repeatability of the method. This method can be commercialized at industrial level for ensuring the highest quality of capsicum used as raw material.

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Review of the Effectiveness of Capsaicin for Painful Cutaneous Disorders and Neural Dysfunction

Cited by 83 publications

References 63 publications

The Two Faces of Capsaicin

The Two Faces of Capsaicin

Involvement of transient receptor potential vanilloid 1 in the vascular and hyperalgesic components of joint inflammation

Validation of Capsaicin in Indian Capsicum Species Through RP-HPLC

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