Review of Synthesis and Antioxidant Potential of Fullerenol Nanoparticles

Djordjević, Aleksandar; Srdjenović, Branislava; Seke, Mariana; Petrović, Danijela; Injac, Rade; Mrdjanović, Jasminka

doi:10.1155/2015/567073

Cited by 81 publications

(62 citation statements)

References 72 publications

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“…In this context the halogenation of fullerenes (with fluorine, chlorine, or bromine) is one of the most common chemical reactions to yield derivatives that can be either used as they are or serve as precursors in substitution reactions to sequentially attach aromatic groups to the fullerene cage [17][18][19][20]. In the case of brominated fullerene the substitution of the bromine with OH groups results in derivatives with better solubility in water and in aqueous solutions [21,22]. Polyhydroxylated fullerene or fullerols (C 60 (OH) n ), have attracted much scientific and industrial attention in engineering [23][24][25], where they were found to improve the corrosion resistance and microhardness of coatings [23], to give better mechanical properties than C 60 , when incorporated in poly(styrene-co-4-vinylpyridine), in catalysis [26][27][28], for optical limiting performance [24] or to reinforce and have antioxidation effects when mixed with natural rubber to inhibit the decrease of tensile strength after aging [25].…”

Section: Introductionmentioning

confidence: 99%

Controlled deposition of fullerene derivatives within a graphene template by means of a modified Langmuir-Schaefer method

Kouloumpis

Vourdas²,

Zygouri

et al. 2018

Journal of Colloid and Interface Science

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The scientific and technological potential of graphene's includes the development of light, open 3D hybrid structures with high surface area, tunable pore size and aromatic functionalities. Towards this aim, we describe a scalable and low-cost bottom-up approach that combines self-assembly and Langmuir-Schaefer deposition for the production of fullerene-intercalated graphene oxide hybrids. This method uses graphene oxide (GO) nanosheets as template for the attachment of two types of fullerene derivatives (bromo-fullerenes, CBr and fullerols, C(OH)) in a bi-dimensional arrangement, allowing a layer-by-layer growth with control at nanoscale. Our film preparation approach relies on a bottom-up process that includes the formation of a hybrid organo-graphene Langmuir film, which is transferred onto a substrate and then brought in contact with C(OH) molecules in solution to induce self-assembly. In the case of grafting CBr molecules into graphene a further modification of the GO platelets was performed by bringing the surface of the transferred GO Langmuir film in contact with a second amino surfactant solution. Repeating these deposition cycles, pillared structures were fabricated in thin films form. These fullerene-based hybrid thin films were characterized by Raman and X-ray photoelectron (XPS) spectroscopies, X-ray diffraction (XRD), Atomic Force Microscopy (AFM) and contact angle measurements.

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Section: Introductionmentioning

confidence: 99%

Controlled deposition of fullerene derivatives within a graphene template by means of a modified Langmuir-Schaefer method

Kouloumpis

Vourdas²,

Zygouri

et al. 2018

Journal of Colloid and Interface Science

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“…Because of their high solubility in water, these fullerene derivates represent attractive nanoparticles for various biological applications [10–14]. In particular, fullerene and its derivates exhibit strong antioxidative, antimicrobial, cytoprotective, neuroprotective and radioprotective effects in animal organisms [10,15–20]. …”

Section: Introductionmentioning

confidence: 99%

Drought Impact Is Alleviated in Sugar Beets (Beta vulgaris L.) by Foliar Application of Fullerenol Nanoparticles

Borišev

Župunski

et al. 2016

PLoS ONE

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Over the past few years, significant efforts have been made to decrease the effects of drought stress on plant productivity and quality. We propose that fullerenol nanoparticles (FNPs, molecular formula C60(OH)24) may help alleviate drought stress by serving as an additional intercellular water supply. Specifically, FNPs are able to penetrate plant leaf and root tissues, where they bind water in various cell compartments. This hydroscopic activity suggests that FNPs could be beneficial in plants. The aim of the present study was to analyse the influence of FNPs on sugar beet plants exposed to drought stress. Our results indicate that intracellular water metabolism can be modified by foliar application of FNPs in drought exposed plants. Drought stress induced a significant increase in the compatible osmolyte proline in both the leaves and roots of control plants, but not in FNP treated plants. These results indicate that FNPs could act as intracellular binders of water, creating an additional water reserve, and enabling adaptation to drought stress. Moreover, analysis of plant antioxidant enzyme activities (CAT, APx and GPx), MDA and GSH content indicate that fullerenol foliar application could have some beneficial effect on alleviating oxidative effects of drought stress, depending on the concentration of nanoparticles applied. Although further studies are necessary to elucidate the biochemical impact of FNPs on plants; the present results could directly impact agricultural practice, where available water supplies are often a limiting factor in plant bioproductivity.

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“…Fullerenols C 60 (OH) [18][19][20][21][22][23][24] have revealed maximal biological activity (4,7,8). Fullerenols demonstrated antioxidant activity, neutralizing reactive oxygen and nitrogen species (5,8,9), correcting neurological diseases (4,5,9,10), as well as functioning as radioprotectors (9) or antitumor agents (6).…”

Section: Introductionmentioning

confidence: 99%

Bioluminescent Enzymatic Assay as a Tool for Studying Antioxidant Activity and Toxicity of Bioactive Compounds

Kudryasheva

Kovel

Sachkova

et al. 2016

Photochem & Photobiology

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A bioluminescent assay based on a system of coupled enzymatic reactions catalyzed by bacterial luciferase and NADH: FMN-oxidoreductase was developed to monitor toxicity and antioxidant activity of bioactive compounds. The assay enables studying toxic effects at the level of biomolecules and physicochemical processes, as well as determining the toxicity of general and oxidative types. Toxic and detoxifying effects of bioactive compounds were studied. Fullerenols, perspective pharmaceutical agents, nanosized particles, water-soluble polyhydroxylated fullerene-60 derivatives were chosen as bioactive compounds. Two homologous fullerenols with different number and type of substituents, C 60 O 2-4 (OH) [20][21][22][23][24] and Fe 0.5 C 60 (OH) x O y (x + y = 40-42), were used. They suppressed bioluminescent intensity at concentrations >0.01 g L À1 and >0.001 g L À1 for C 60 O 2-4 (OH) 20-24 and Fe 0.5 C 60 (OH) x O y , respectively; hence, a lower toxicity of C 60 O 2-4 (OH) 20-24 was demonstrated. Antioxidant activity of fullerenols was studied in model solutions of organic and inorganic oxidizers; changes in toxicities of general and oxidative type were determined; detoxification coefficients were calculated. Fullerenol C 60 O 2-4 (OH) 20-24 revealed higher antioxidant ability at concentrations 10 À17 À10 À5 g L À1 . The difference in the toxicity and antioxidant activity of fullerenols was explained through their electron donor/acceptor properties and different catalytic activity. Principles of bioluminescent enzyme assay application for evaluating the toxic effect and antioxidant activity of bioactive compounds were summarized.

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Review of Synthesis and Antioxidant Potential of Fullerenol Nanoparticles

Cited by 81 publications

References 72 publications

Controlled deposition of fullerene derivatives within a graphene template by means of a modified Langmuir-Schaefer method

Controlled deposition of fullerene derivatives within a graphene template by means of a modified Langmuir-Schaefer method

Drought Impact Is Alleviated in Sugar Beets (Beta vulgaris L.) by Foliar Application of Fullerenol Nanoparticles

Bioluminescent Enzymatic Assay as a Tool for Studying Antioxidant Activity and Toxicity of Bioactive Compounds

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