Review of Soluble Biomarkers of Osteoarthritis: Lessons From Animal Models

Legrand, Catherine; Lambert, Cécile; Comblain, Fanny; Sanchez, Christelle; Henrotin, Yves

doi:10.1177/1947603516656739

Cited by 21 publications

(21 citation statements)

References 151 publications

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“…However, presented results suggest that biomarkers of cartilage metabolism may be more useful for detection of racehorses currently at risk of suffering musculoskeletal injury, which could be of practical importance if regular monitoring of GAG and CPII during racing season was performed. CPII and GAG level changes have been previously demonstrated to correlate with imaging and histopathological outcomes in diagnosis and severity classification of equine osteoarthritis [48, 49], further confirming their relevance as biomarkers of joint injury in that species.…”

Section: Discussionmentioning

confidence: 64%

Revisiting predictive biomarkers of musculoskeletal injury in thoroughbred racehorses: longitudinal study in polish population

2019

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Background High prevalence of musculoskeletal disorders in racehorses and its impact on horse welfare and racing economics call for improved measures of injury diagnosis and prevention. Serum biomarkers of bone and cartilage metabolism have previously shown promise in prediction of musculoskeletal injuries in horses. This study aimed to re-evaluate usability of the predictive serum biomarkers identified in North American Thoroughbred racehorses in a geographically distinct group of Polish Thoroughbreds. Results Serum concentrations of bone and cartilage biomarkers: osteocalcin, c-terminal telopeptide of type I collagen, total glycosaminoglycans (GAG), chondroitin sulfate epitope and c-propeptide of type II procollagen (CPII) were evaluated in the beginning and the next 3 months of one racing season in a cohort of twenty-six 2-year-old Polish racehorses. Exit criteria were diagnosis of musculoskeletal injury, leading to > 5 days off training ( n = 8), or completion of 3 study months with no training interruptions ( n = 18). Normalized results and matching archival data from 35 2-year-old North American racehorses was used for logistic regression analysis to identify universal predictors of injury. Mean GAG and CPII levels were lower in injured group comparing to control, which is consistent with previous findings in racehorses. These biomarkers were also identified as predictors of injury in the mixed population model. Population origin had no significant effect on predictive value of evaluated biomarkers (Wald test p = 0.137). Decreased osteocalcin and increased c-terminal telopeptide of type I collagen levels in injured horses comparing to controls were specific for Polish population and signalized disruption in bone turnover homeostasis. Conclusions Changes in serum GAG and CPII in racehorses at risk of injury appear to be similar across distinct populations while dynamics of serum bone marker is more population-specific. Electronic supplementary material The online version of this article (10.1186/s12917-019-1799-7) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 64%

Revisiting predictive biomarkers of musculoskeletal injury in thoroughbred racehorses: longitudinal study in polish population

2019

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“…Other studies suggested that bone biomarkers like osteopontin and bone sialoprotein are more relevant in the pathogenesis of osteoarthritis [37]. Studies also found that CTX-II correlated better with disease progression of osteoarthritis [38,39].…”

Section: Discussionmentioning

confidence: 99%

The Effects of Annatto Tocotrienol Supplementation on Cartilage and Subchondral Bone in an Animal Model of Osteoarthritis Induced by Monosodium Iodoacetate

Chin

Wong

Sidik

et al. 2019

IJERPH

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Osteoarthritis is a degenerative joint disease which primarily affects the articular cartilage and subchondral bones. Since there is an underlying localized inflammatory component in the pathogenesis of osteoarthritis, compounds like tocotrienol with anti-inflammatory properties may be able to retard its progression. This study aimed to determine the effects of oral tocotrienol supplementation on the articular cartilage and subchondral bone in a rat model of osteoarthritis induced by monosodium iodoacetate (MIA). Thirty male Sprague-Dawley rats (three-month-old) were randomized into five groups. Four groups were induced with osteoarthritis (single injection of MIA at week 0) and another served as the sham group. Three of the four groups with osteoarthritis were supplemented with annatto tocotrienol at 50, 100 and 150 mg/kg/day orally for five weeks. At week 5, all rats were sacrificed, and their tibial-femoral joints were harvested for analysis. The results indicated that the groups which received annatto tocotrienol at 100 and 150 mg/kg/day had lower histological scores and cartilage remodeling markers. Annatto tocotrienol at 150 mg/kg/day significantly lowered the osteocalcin levels and osteoclast surface of subchondral bone. In conclusion, annatto tocotrienol may potentially retard the progression of osteoarthritis. Future studies to confirm its mechanism of joint protection should be performed.

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“…Osteoarthritis is a whole joint illness. It is a slow progression long-standing inflammatory disorder that produces gradual articular cartilage destruction, accompanied by alterations of articular soft-tissue and bone and finally leading to pain, joint rigidity, and limb dysfunction (Legrand et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Effect of Platelet-Rich Plasma on MMP-13, ARE and TGF β1 in MIA-induced Osteoarthritis in Rats

Halfaya

Ragab

Hagag

et al. 2020

Journal of Veterinary Medical Research

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Ankle osteoarthritis (OA) is an inflammatory deterioration chronic disease; yet, OA pathogenesis is obscure. There is no absolute cure from OA and the present pharmacological medication options are constrained and associated with adverse aspect effects. Clinically, Platelet-rich plasma (PRP) is usually used to cure OA. The present study was designed to evaluate the role of PRP in the treatment of experimentally Monosodium iodoacetate (MIA)-induced ankle osteoarthritis in the rat model. Thirty male Wistar rats were divided into three groups (each of 10 rats). Rats of group I were injected with 1 mg MIA in the right ankle joint for two consecutive days, while those of group II were treated with saline instead of MIA; and group III (osteoarthritic +PRP) rats were injected with PRP in the ankle joint at 14, 21, and 28 days after MIA injection. Paw oedema, scoring of arthritis, Matrix metalloproteinase 13 (MMP13) level, antioxidant response element (ARE) level, and joint transforming growth factor beta1 (TGF β 1) were evaluated. PRP reduces expression of joint, MMP13, ARE level, and TGF β 1. PRP also significantly reduces the score of arthritis. The administration of PRP decreases paw oedema in MIA-induced OA rats. These results suggest that PRP has marked effect against OA in MIA-induced osteoarthritic rats which are mediated through the anti-inflammatory and antioxidant effects.

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Review of Soluble Biomarkers of Osteoarthritis: Lessons From Animal Models

Cited by 21 publications

References 151 publications

Revisiting predictive biomarkers of musculoskeletal injury in thoroughbred racehorses: longitudinal study in polish population

Revisiting predictive biomarkers of musculoskeletal injury in thoroughbred racehorses: longitudinal study in polish population

The Effects of Annatto Tocotrienol Supplementation on Cartilage and Subchondral Bone in an Animal Model of Osteoarthritis Induced by Monosodium Iodoacetate

Effect of Platelet-Rich Plasma on MMP-13, ARE and TGF β1 in MIA-induced Osteoarthritis in Rats

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