Review of Poultry Recombinant Vector Vaccines

Hein, R.; Koopman, Rik; Garcı́a, Maricarmen; Armour, Natalie; Dunn, John R.; Barbosa, Taylor; Martinez, Algis

doi:10.1637/0005-2086-65.3.438

Cited by 36 publications

(42 citation statements)

References 165 publications

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“…Viruses such as fowl pox virus (FPV), turkey herpesvirus (HVT), adenovirus, ILT and MDV are established recombinant viral vectors used in the production of poultry viral vaccines [16,17]. Among the commercially approved recombinant virus vector poultry vaccines, two of the most commonly used viral vectors are an attenuated fowl pox virus (FPV) [18] and turkey herpesvirus (HVT) [19].…”

Section: Recombinant Virus Vector Vaccinesmentioning

confidence: 99%

“…Lastly, recombinant viral vector can be modified to accommodate immunogens from two different pathogens for broadening the scope of protection. An example is the successful incorporation of IBD and ND (Vaxxitek ® and Innovax ® ) and IBDV and ILTV (Farmune ® -HVT-IBD-LT) into rHVT for the production of trivalent vaccines [16,24].…”

Section: Recombinant Virus Vector Vaccinesmentioning

confidence: 99%

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Vaccines against Major Poultry Viral Diseases: Strategies to Improve the Breadth and Protective Efficacy

Rajamanonmani

Chan

Prabakaran

2022

Viruses

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The poultry industry is the largest source of meat and eggs for human consumption worldwide. However, viral outbreaks in farmed stock are a common occurrence and a major source of concern for the industry. Mortality and morbidity resulting from an outbreak can cause significant economic losses with subsequent detrimental impacts on the global food supply chain. Mass vaccination is one of the main strategies for controlling and preventing viral infection in poultry. The development of broadly protective vaccines against avian viral diseases will alleviate selection pressure on field virus strains and simplify vaccination regimens for commercial farms with overall savings in husbandry costs. With the increasing number of emerging and re-emerging viral infectious diseases in the poultry industry, there is an urgent need to understand the strategies for broadening the protective efficacy of the vaccines against distinct viral strains. The current review provides an overview of viral vaccines and vaccination regimens available for common avian viral infections, and strategies for developing safer and more efficacious viral vaccines for poultry.

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Section: Recombinant Virus Vector Vaccinesmentioning

confidence: 99%

Section: Recombinant Virus Vector Vaccinesmentioning

confidence: 99%

Vaccines against Major Poultry Viral Diseases: Strategies to Improve the Breadth and Protective Efficacy

Rajamanonmani

Chan

Prabakaran

2022

Viruses

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“…The results of the Vaxxitek R -specific LAMP-LFD assay confirmed that the assay was specific for VAXXITEK R HVT -IBD detection and did not detect MDV-1, MDV-2, and, more importantly, conventional HVT vaccines or other rHVT vaccines (e.g., Innovax R ). The expression cassettes with foreign genes encoding immunogenic viral proteins inserted in the HVT genome and their sequences differ between recombinant vaccines produced by different pharmaceutical companies and are not present in conventional HVT vaccine strains ensuring the differentiation of the different vaccine strains based on their sequence (49,50). The three-in-one vaccines recently added to the Vaxxitek R range (VAXXITEK R HVT + IBD + ND, and VAXXITEK R HVT + IBD + ILT) use the same bioengineering platform as VAXXITEK R HVT + IBD, so we predict that our Vaxxitek R -specific LAMP-LFD assay will detect all Vaxxitek R vaccines.…”

Section: Discussionmentioning

confidence: 99%

Rapid, Sensitive, and Species-Specific Detection of Conventional and Recombinant Herpesvirus of Turkeys Vaccines Using Loop-Mediated Isothermal Amplification Coupled With a Lateral Flow Device Readout

et al. 2022

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Marek's disease, an economically important disease of chickens caused by virulent serotype 1 strains of the Mardivirus Marek's disease virus (MDV-1), is effectively controlled in the field by live attenuated vaccine viruses including herpesvirus of turkeys (HVT)—both conventional HVT (strain FC126) and, in recent years, recombinant HVT viruses carrying foreign genes from other avian viruses to protect against both Marek's disease and other avian viral diseases. Testing to monitor and confirm successful vaccination is important, but any such test must differentiate HVT from MDV-1 and MDV-2, as vaccination does not prevent infection with these serotypes. End-point and real-time PCR tests are widely used to detect and differentiate HVT, MDV-1 and MDV-2 but require expensive specialist laboratory equipment and trained operators. Here, we developed and validated two tube-based loop-mediated isothermal amplification tests coupled with detection by lateral flow device readout (LAMP-LFD): an HVT-specific test to detect both conventional and recombinant HVT strains, and a second test using novel LAMP primers to specifically detect the Vaxxitek® recombinant HVT. Specificity was confirmed using DNA extracted from virus-infected cultured cells, and limit of detection was determined using plasmid DNA carrying either the HVT or Vaxxitek® genome. The LAMP-LFD tests accurately detected all HVT vaccines, or Vaxxitek® only, in crude DNA as well as purified DNA extracted from field samples of organs, feathers, or poultry house dust that were confirmed positive for HVT by real-time PCR. These LAMP-LFD tests have potential for specific, rapid, simple, and inexpensive detection of HVT vaccines in the field.

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“…Previously, live vector vaccines have exhibited variable sensitivity to MDAs 48 . For example, Herpesvirus of Turkey (HVT) expressing AIV HA protein has demonstrated less sensitivity to MDAs and shown to protect chickens even in the presence of MDAs 45 , 49 .…”

Section: Discussionmentioning

confidence: 99%

Haemagglutinin antigen selectively targeted to chicken CD83 overcomes interference from maternally derived antibodies in chickens

Shrestha

Meeuws²,

Sadeyen

et al. 2022

npj Vaccines

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Maternally derived antibodies (MDAs) are important for protecting chickens against pathogens in the neonatal stage however, they often interfere with vaccine performance. Here, we investigated the effects of MDAs on a targeted antigen delivery vaccine (TADV), which is developed by conjugating H9 subtype avian influenza virus haemagglutinin (HA) antigen to single chain fragment variable (scFv) antibodies specific for the chicken antigen presenting cell receptor CD83. Groups of 1-day-old chickens carrying high levels of MDAs (MDA++) and 14-day old chickens carrying medium levels of MDAs (MDA+) were immunised with TADV (rH9HA-CD83 scFv), untargeted rH9HA or inactivated H9N2 vaccines. Immunogenicity in these vaccinated chickens was compared using haemagglutination inhibition (HI) and enzyme-linked immunosorbent assays (ELISA). The results showed that the TADV (rH9HA-CD83 scFv) induced significantly higher levels of H9HA-specific antibody titres compared to the untargeted rH9HA and inactivated H9N2 vaccines in MDA++ and MDA+ chickens. Overall, the data demonstrates immune responses induced by TADV are not affected by the MDA in chickens.

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Review of Poultry Recombinant Vector Vaccines

Cited by 36 publications

References 165 publications

Vaccines against Major Poultry Viral Diseases: Strategies to Improve the Breadth and Protective Efficacy

Vaccines against Major Poultry Viral Diseases: Strategies to Improve the Breadth and Protective Efficacy

Rapid, Sensitive, and Species-Specific Detection of Conventional and Recombinant Herpesvirus of Turkeys Vaccines Using Loop-Mediated Isothermal Amplification Coupled With a Lateral Flow Device Readout

Haemagglutinin antigen selectively targeted to chicken CD83 overcomes interference from maternally derived antibodies in chickens

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