Purpose: This study was to examine the effects of tailored drug-related side effects management program using video designed to help patients with schizophrenia with self-control ability of drug-related side effects, attitude, and adherence to medication. Methods: A non-equivalent control group, pretest-posttest design was used. The participants were 51 patients with schizophrenia, 26 in the experimental group and 25 in the control group. The tailored drug-related side effects management program using video was conducted for the experimental group twice a week for 60 minutes/session for 4 weeks. The self-control ability for drug-related side effects, attitude and adherence of medication were measured before and after the experiment. Data were analyzed by using IBM SPSS/WIN 20.0 program. Results: At follow-up, we found statistically significant increases in self-control ability for drug-related side effects, attitude and adherence of medication for the experimental group. Conclusion: The results of this study suggest that tailored drug-related side effects management program using video was to increase self-control ability for drug-related side effects, attitude and adherence of medication in patients with schizophrenia.