Review of Nonmelanoma Skin Cancer in African Americans, Hispanics, and Asians

Higgins, Shauna; Nazemi, Azadeh; Chow, Maggie; Wysong, Ashley

doi:10.1097/dss.0000000000001547

Cited by 62 publications

(53 citation statements)

References 37 publications

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“…Review of pattern of occurrence in African Americans, in keeping with our present findings, highlights SCC as the most common skin cancer in blacks, with lower limbs and anogenital regions as the most frequently involved body sites. 30,32,33 The preferred involvement of sun-exposed body sites in African albinos and occurrence of multiple tumors correspond to the reported pattern of keratinocyte carcinomas in Caucasians. 21,34 In one study, 31 38% of white patients had multiple tumors ranging from 2 to 52, some of which were mixed SCC and BCC.…”

Section: Discussionsupporting

confidence: 75%

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Primary cutaneous malignancies in nonalbino and albino Africans

Okafor

Onyishi

2020

Int J Dermatology

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Background The pigmented skin of black Africans has been credited with reduction in risk of skin cancer. African albinos have inherited defects in skin melanin deposition, which predisposes them to ultraviolet radiation‐induced cutaneous carcinogenesis. We compared the manifestation of skin cancers between albino and nonalbino Africans aiming to describe the effect of pigmentation or lack of it on the epidemiological characteristics of skin cancer in Africans. Materials and methods Cutaneous malignancies seen in our institution over a 19‐year period were analyzed using SPSS statistical software. Results were presented in tables of frequencies. Continuous variables were presented as mean with standard deviation and compared with independent sample t‐test and ANOVA. Alpha level of <0.05 was considered significant. Result There were 86 albinos and 364 nonalbinos in the study. Mean age (SD) at presentation for albinos was 41 (14) years and for nonalbinos 52 (17) years. Albinos had most tumors in the head and neck region and upper extremities. For nonalbinos, lower extremities followed by anogenital region were the most common body site of cutaneous malignancy. Squamous cell carcinoma was the most common type of skin cancer in the albino and nonalbino patients. No case of malignant melanoma was diagnosed in the albino group. Conclusion Albino skin cancer patients were much younger than nonalbinos. Albinos and nonalbinos differ in body site distribution of skin cancers. Distribution of keratinocyte carcinomas in albinos parallels the reported findings in Caucasians. Albinos may have some level of protection from cutaneous melanoma in spite of hypomelanized skin.

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Section: Discussionsupporting

confidence: 75%

“…29 Conservatively, 19-40% of SCC cases in black populations could be associated with a chronic inflammatory or scarring process. 3,29,33 In our study, Kaposi sarcoma and DFSP occurred at a relatively lower mean age compared with keratinocyte carcinomas and melanomas. This finding is consistent with previous reports.…”

Section: Discussionmentioning

confidence: 46%

Primary cutaneous malignancies in nonalbino and albino Africans

Okafor

Onyishi

2020

Int J Dermatology

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“…However, our data are comparable to data from countries in similar geographic zones and with populations with darker skin tone. 24 , 25 Exposure to ultraviolet rays from the sun are considered to be an important predisposing risk factor for skin cancer. 9 , 26 Low skin-cancer incidence may result from unknown genetic factors, the protective influence of the melanin pigment against sun rays, and daily lifestyle, daytime outdoors activities, and traditional customs and clothes allowing little sun exposure.…”

Section: Discussionmentioning

confidence: 99%

Histopathological pattern of skin cancer in Western region of Saudi Arabia

Albasri

Borhan²

2018

SMJ

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Objectives:To determine the histopathological pattern of skin cancer in Madinah region of Kingdom of Saudi Arabia (KSA).Methods:This is a retrospective study including all cases with a histological diagnosis of skin cancer diagnosed at the Department of Pathology, King Fahad Hospital, Madinah, Saudi Arabia, between January 2006 and December 2017. Data included age, gender, site and histology of the tumor were collected from histopathological reports and analyzed using Statistical Package for the Social Sciences (SPSS) Version 21.Results:Among the 202 cancer cases studied in our series, there were 124 (61.4%) cases of basal cell carcinoma (BCC), 33 (16.3%) cases of squamous cell carcinoma (SCC), 14 (6.8%) cases of mycosis fungoides (MF), 12 (5.8%) cases of dermatofibrosarcoma protuberans (DFSP) and 7 (3.7%) cases of malignant melanomas (MM). The male to female ratio for all cases was 2.2:1. The ages ranged from 5 to 100 years with a mean age of 60.1±15 years. The peak age distribution was in the 60-69 year group. The most common site involved in BCC and SCC was the head and neck (92.7% and 66.7%) respectively). Acral distribution of MM was seen in 57.1% of the cases.Conclusion:Our data based on the histopathology history in the Madinah region match that in the world literature and Saudi national studies.

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“…Según recientes estimaciones, 1 de cada 5 estadounidenses durante toda su vida desarrollan cáncer de piel (tanto melanomatoso como no melanomatoso) y diariamente se diagnostican más de 8,500 personas en los Estados Unidos con este tipo de neoplasia (1,7). Lamentablemente se desconoce la cifra exacta de la incidencia del carcinoma basocelular, esto debido a que no se cuenta con un registro preciso de los casos diagnosticados en la mayoría de países a nivel mundial.…”

Section: Epidemiologíaunclassified

“…Sin embargo, la Sociedad Americana de Cáncer, estima que en el 2012 se diagnosticaron 5,4 millones de casos de cáncer de piel no melanomatoso en 3.3 millones de personas, de los cuales aproximadamente 8 de cada 10 se trataba de un CBC (8). Además, en el 2013, The National Comprehensive Cancer Network (NCCN), estimó que se diagnostican anualmente más de 2 millones de casos de cáncer de piel no melanomatoso, e igualmente el tipo más frecuente es el CBC (7,9). Se describe por parte de las principales guías internacionales de dermatología, un aumento de 10% por año en la incidencia del carcinoma basocelular, y según dependiendo de los factores de riesgo, la probabilidad y la prevalencia de este cáncer varía de manera considerable; por ejemplo, los caucásicos, quienes tienen un riesgo de desarrollar CBC en algún momento de su vida de 33 a 39% en hombres y un 23 a 28% en mujeres (1); lo cual difiere de la raza negra, en la que esta neoplasia es poco frecuente (8), pero confiere una alta morbimortalidad (7,9).…”

Section: Epidemiologíaunclassified

Revisión sistemática del carcinoma basocelular

2020

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El cáncer de piel representa el tumor maligno más frecuente a nivel mundial, siendo el carcinoma basocelular el tipo más frecuente de neoplasia cutánea. Esta tumoración se origina de la capa basal de la epidermis o del bulbo del folículo piloso, y su patogenia ha sido investigada cada vez más con el paso de los años debido al incremento en la incidencia. Se han identificado los factores de riesgo de mayor relevancia y una serie de mutaciones en algunos genes supresores de tumores y alteraciones en la vía de señalización Hedgehog; ambas situaciones vinculadas con su patogénesis. En la actualidad, se cuenta con herramientas diagnósticas fácilmente accesibles que permiten una detección más temprana y oportuna de la enfermedad. Sin embargo, dicha neoplasia cutánea continúa generando un problema de salud pública considerable por su importante morbilidad e incidencia, lo que conduce a un elevado costo económico en el área salud.

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Review of Nonmelanoma Skin Cancer in African Americans, Hispanics, and Asians

Abstract: Familiarization with these unique presentations of skin cancer in skin of color is imperative to accurate identification and treatment of cutaneous malignancies in these populations and ultimately to improved disease-related outcomes.

Cited by 62 publications

References 37 publications

Primary cutaneous malignancies in nonalbino and albino Africans

Primary cutaneous malignancies in nonalbino and albino Africans

Histopathological pattern of skin cancer in Western region of Saudi Arabia

Revisión sistemática del carcinoma basocelular

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