Review of metallic biomaterials in dental applications

Kumar, Sandeep; Devi, S. Prasanna; Krithika, Chandrasekaran; Raghavan, RN

doi:10.4103/jpbs.jpbs_88_20

Cited by 21 publications

(24 citation statements)

References 35 publications

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“…For these reasons (the disputable aesthetics of dental metals and alloys, as well as their physical and chemical properties), the research for other types of dental materials, preferably metal-free, are sustained [ 12 , 13 ]. The benefits of metal-free biomaterials for dental restorations are represented by a more natural appearance without metallic elements, for an easier correction of the shade, to match to any tooth, to be highly attractive, and to look and feel like the natural teeth [ 14 , 15 ]. The metal-free prosthetic restorations present biocompatibility; therefore, the negative impact of metal on the patient’s body is eliminated [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Behavior of Two CAD/CAM Fiber-Reinforced Composite Dental Materials by Immersion Tests

et al. 2021

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Fiber-reinforced composites are used as restorative materials for prosthetic oral rehabilitation. Gastroesophageal reflux disease (GERD) is an accustomed affection with various oral manifestations. This study aimed to evaluate the behavior of two high-performance CAD/CAM milled reinforced composites (Trinia™, TriLor) in artificial saliva at different pH levels through immersion tests, and to determine if changes in mass or surface morphology at variable pH, specific for patients affected by GERD, appear. After investigating the elemental composition and surface morphology, the specimens were immersed in Carter Brugirard artificial saliva for 21 days at different pH values (5.7, 7.6, and varying the pH from 5.7 to 3). The values of the weighed masses during the immersion tests were statistically processed in terms of mean and standard deviation. Results suggested that irrespective of the medium pH, the two composites presented a similar mass variation in the range of −0.18 (±0.01)–1.82 (±0.02) mg after immersion, suggesting their stability when in contact with artificial saliva, an aspect which was also highlighted by scanning electron microscope (SEM) analysis performed on the immersed surfaces. Novel composite biomaterials can be a proper alternative for metal alloys used for prosthetic frameworks in patients suffering from GERD.

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Section: Introductionmentioning

confidence: 99%

Evaluation of the Behavior of Two CAD/CAM Fiber-Reinforced Composite Dental Materials by Immersion Tests

et al. 2021

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“…A study showed that Ga 3+ interacts with cellular particles and HA of bone. That means Ga 3+ can resist bone resorption when used in patients with osteoporosis ( Tharani Kumar et al, 2020 ). Moreover, it should be noted that Ga 3+ also has the function of treating cancer-induced hypercalcemia and inhibiting the growth of tumor cells ( Farrell et al, 2018 ).…”

Section: Functionalization Of the Implant Surfacementioning

confidence: 99%

Advanced Surface Modification for 3D-Printed Titanium Alloy Implant Interface Functionalization

Sheng

Wang

et al. 2022

Front. Bioeng. Biotechnol.

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With the development of three-dimensional (3D) printed technology, 3D printed alloy implants, especially titanium alloy, play a critical role in biomedical fields such as orthopedics and dentistry. However, untreated titanium alloy implants always possess a bioinert surface that prevents the interface osseointegration, which is necessary to perform surface modification to enhance its biological functions. In this article, we discuss the principles and processes of chemical, physical, and biological surface modification technologies on 3D printed titanium alloy implants in detail. Furthermore, the challenges on antibacterial, osteogenesis, and mechanical properties of 3D-printed titanium alloy implants by surface modification are summarized. Future research studies, including the combination of multiple modification technologies or the coordination of the structure and composition of the composite coating are also present. This review provides leading-edge functionalization strategies of the 3D printed titanium alloy implants.

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“…Advances in metallic based biomaterials were dynamically achieved over the last years and have proposed optimized materials in the biomedical field to replace or sustain a lost bone function [ 1 ]. There are many characteristics of metal implants that develop essential functions in the success of biomaterial biocompatibility and performance, and these issues affect several biological processes, such as endothelial cells (EC) and blood platelets, responsible for triggering signaling involved with local inflammation, blood coagulation, angiogenesis, and others [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Nanohydroxyapatite-Blasted Bioactive Surface Drives Shear-Stressed Endothelial Cell Growth and Angiogenesis

Pinto

Martins

Ferreira

et al. 2022

BioMed Research International

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Nanosized crystalline hydroxyapatite coating (HAnano®) accelerates the osteointegration of dental implants which is hypothesized to drive angiogenesis. In order to test this hypothesis, we have subjected shear-stressed human umbilical vein endothelial cells (HUVECs) to a HAnano®-enriched medium, as well as to surface presenting dual acid etching (DAE) as a control. To note, the titanium implants were coated with 10 nm in diameter HA particles using the Promimic HAnano method. Our data reveals that HAnano® modulates higher expression of genes related with endothelial cell performance and viability, such as VEGF, eNOS, and AKT, and further angiogenesis in vitro by promoting endothelial cell migration. Additionally, the data shows a significant extracellular matrix (ECM) remodeling, and this finding seems developing a dual role in promoting the expression of VEGF and control endothelial cell growth during angiogenesis. Altogether, these data prompted us to further validate this phenomenon by exploring genes related with the control of cell cycle and in fact our data shows that HAnano® promotes higher expression of CDK4 gene, while p21 and p15 genes (suppressor genes) were significantly lower. In conjunction, our data shows for the first time that HAnano®-coated surfaces drive angiogenesis by stimulating a proliferative and migration phenotype of endothelial cells, and this finding opens novel comprehension about osseointegration mechanism considering nanosized hydroxyapatite coating dental implants.

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Review of metallic biomaterials in dental applications

Cited by 21 publications

References 35 publications

Evaluation of the Behavior of Two CAD/CAM Fiber-Reinforced Composite Dental Materials by Immersion Tests

Evaluation of the Behavior of Two CAD/CAM Fiber-Reinforced Composite Dental Materials by Immersion Tests

Advanced Surface Modification for 3D-Printed Titanium Alloy Implant Interface Functionalization

Nanohydroxyapatite-Blasted Bioactive Surface Drives Shear-Stressed Endothelial Cell Growth and Angiogenesis

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