Review of Mammarenavirus Biology and Replication

Hallam, Steven J.; Koma, Takaaki; Maruyama, Junki; Paessler, Slobodan

doi:10.3389/fmicb.2018.01751

Cited by 71 publications

(70 citation statements)

References 87 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The S portion encodes nucleocapsid protein and envelope glycoproteins, while L segment contains RNA dependent RNA polymerase (RdRp) and zincbinding protein genes. Both S and L intergenic regions may potentially form one or more hairpins, which regulate mRNA transcription 53,[144][145][146] .…”

Section: Arenavirus (Av)mentioning

confidence: 99%

“…This viral family has four genera, based on phylogenetic analysis involving pairwise sequence comparisons (PASC) of complete genomes 53,147 . Antennavirus genus includes viruses that infect frogfish 148 , Hartmanivirus and Reptarenavirus infect snakes, and Mammarenavirus, which have been reported in bats, ticks, rodents, and primates, including humans 146,147 .…”

Section: Arenavirus (Av)mentioning

confidence: 99%

“…Mammarenaviruses are correlated to the geographical location where their hosts are found 147 ; currently classified as: (a) Old World (OW) (Lassa virus, Lujo virus, among others), and found mainly in Africa in rodents of the Murinae family as natural hosts 149 . Although Lymphocytic choriomeningitis virus (LCMV) belongs to this category, it circulates globally 146 . Approximately 5% of the human population have been exposed to LCMV, due to the ubiquity of the virus host, M. musculus 150 ; (b) New World (NW), found in the American continent, are divided into four clades (A-D) 151 .…”

Section: Arenavirus (Av)mentioning

confidence: 99%

“…Members of both OW and NW arenaviruses can cause hemorrhagic fever and severe human diseases affecting the central nervous system 158 . Zoonotic transmission is through contact with rodents' urine or feces, and human-to-human transmission is possible 146 . Because of their impact on human health and rapid spread, they are potential bioterrorism agents 159 .…”

Section: Arenavirus (Av)mentioning

confidence: 99%

See 3 more Smart Citations

Synanthropic rodents as virus reservoirs and transmitters

Gravinatti

Barbosa

Soares

et al. 2020

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

This review focuses on reports of hepatitis E virus, hantavirus, rotavirus, coronavirus, and arenavirus in synanthropic rodents (Rattus rattus, Rattus norvegicus, and Mus musculus) within urban environments. Despite their potential impact on human health, relatively few studies have addressed the monitoring of these viruses in rodents. Comprehensive control and preventive activities should include actions such as the elimination or reduction of rat and mouse populations, sanitary education, reduction of shelters for the animals, and restriction of the access of rodents to residences, water, and food supplies.

show abstract

Section: Arenavirus (Av)mentioning

confidence: 99%

Section: Arenavirus (Av)mentioning

confidence: 99%

Section: Arenavirus (Av)mentioning

confidence: 99%

Section: Arenavirus (Av)mentioning

confidence: 99%

See 2 more Smart Citations

Synanthropic rodents as virus reservoirs and transmitters

Gravinatti

Barbosa

Soares

et al. 2020

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

show abstract

“…The origins and reservoir hosts of both reptarenaviruses and hartmaniviruses remain unknown, as the viruses have only been found in captive snakes [13,15,17,24,25].Arenaviruses have a negative-sense bi-segmented RNA genome, with the exception of members of the most recently recognized arenavirus genus, Antennavirus, identified in fish, which have a tri-segmented genome [19]. The large (L) genome segment encodes the RNA-dependent-RNApolymerase (RdRp) and the matrix-like Z protein (ZP) [26,27], but hartmaniviruses lack the ZP [22]. The small (S) segment encodes the glycoprotein precursor protein (GPC) and the NP [28][29][30][31].…”

mentioning

confidence: 99%

Differences in Tissue and Species Tropism of Reptarenavirus Species Studied by Vesicular Stomatitis Virus Pseudotypes

Korzyukov

Iheozor-Ejiofor

Levanov

et al. 2020

Viruses

View full text Add to dashboard Cite

Reptarenaviruses cause Boid Inclusion Body Disease (BIBD), and co-infections by several reptarenaviruses are common in affected snakes. Reptarenaviruses have only been found in captive snakes, and their reservoir hosts remain unknown. In affected animals, reptarenaviruses appear to replicate in most cell types, but their complete host range, as well as tissue and cell tropism are unknown. As with other enveloped viruses, the glycoproteins (GPs) present on the virion's surface mediate reptarenavirus cell entry, and therefore, the GPs play a critical role in the virus cell and tissue tropism. Herein, we employed single cycle replication, GP deficient, recombinant vesicular stomatitis virus (VSV) expressing the enhanced green fluorescent protein (scrVSV∆G-eGFP) pseudotyped with different reptarenavirus GPs to study the virus cell tropism. We found that scrVSV∆G-eGFPs pseudotyped with reptarenavirus GPs readily entered mammalian cell lines, and some mammalian cell lines exhibited higher, compared to snake cell lines, susceptibility to reptarenavirus GP-mediated infection. Mammarenavirus GPs used as controls also mediated efficient entry into several snake cell lines. Our results confirm an important role of the virus surface GP in reptarenavirus cell tropism and that mamma-and reptarenaviruses exhibit high cross-species transmission potential.Viruses 2020, 12, 395 2 of 16 Boid Inclusion Body Disease (BIBD), initially recognized in the 1970s, affects mainly captive boas and pythons [11]. BIBD is characterized by the formation of electron dense intracytoplasmic inclusion bodies (IB) [12] in various cell types (including blood cells) and tissues [13][14][15]. BIBD spreads efficiently within collections, and the recommendation to euthanize snakes with BIBD can lead to loss of entire collections [11]. Clinical manifestations of BIBD are variable and include central nervous system (CNS) signs such as head tremors, loss of coordination, and regurgitation [11]. Death due to secondary bacterial, fungal or protozoal infections and neoplastic diseases is common in snakes with BIBD [16], suggesting that BIBD might be associated with an impaired immune response.The causative agent for BIBD remained unknown until the early 2010s, when novel arenaviruses were identified in snakes with BIBD [13,15,17], which extended arenaviruses host range to species other than the well-established rodent reservoirs [1-3]. These findings led to establishment of two genera, Mammarenavirus and Reptarenavirus, within the family Arenaviridae [18,19]. We and others have documented that snakes with BIBD are often co-infected with several reptarenaviruses [20,21], and we discovered another novel arenavirus in snakes, Haartman Institute Snake virus-1 (HISV-1) [20], which later became the type species of a third arenavirus genus, Hartmanivirus [19,22]. The finding that IBs contain reptarenavirus NP further supported the link between reptarenavirus infection and BIBD [15]. Experimental infection of boas and pythons with purified reptarenaviruses provided une...

show abstract

Negative‐strand RNA Viruses

Fearns

2021

Virology

View full text Add to dashboard Cite

Review of Mammarenavirus Biology and Replication

Cited by 71 publications

References 87 publications

Synanthropic rodents as virus reservoirs and transmitters

Synanthropic rodents as virus reservoirs and transmitters

Differences in Tissue and Species Tropism of Reptarenavirus Species Studied by Vesicular Stomatitis Virus Pseudotypes

Negative‐strand RNA Viruses

Contact Info

Product

Resources

About