Review of Long-Term Trials with Nitrendipine

Ul, Hulthén; Pl, Katzman

doi:10.1097/00005344-198806124-00004

Cited by 6 publications

(4 citation statements)

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“…This study demonstrated that nitrendipine was effective in reducing blood pressure in mild to moderate hypertensive patients, as reported by other authors [1][2][3][4][5][6][7][8], and its antihypertensive efficacy was comparable to HCT. In our study nitrendipine (20 mg daily) normalized blood pressure (DBP -< 90 mmHg) in 77% of treated hypertensive patients without significant side effects.…”

Section: Discussionsupporting

confidence: 87%

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Antihypertensive efficacy and effects of nitrendipine on cardiac and renal hemodynamics in mild to moderate hypertensive patients: Randomized controlled trial versus hydrochlorothiazide

Scaglione

Indovina

Parrinello

et al. 1992

Cardiovasc Drug Ther

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In this study antihypertensive efficacy, safety, and the effects of short-term nitrendipine administration on central and renal hemodynamics were evaluated in mild to moderate hypertensives. Our final goal was to ascertain whether the reduction in blood pressure induced by nitrendipine treatment was associated with maintained renal function. After a run-in period with placebo, 26 hypertensives without cardiac or renal disease were randomly assigned to a double-blind 8-week controlled trial with nitrendipine (N) 20 mg once a day (13 pts) or hydrochlorothiazide (HCT) 25 mg once a day (13 pts). Renal hemodynamic measurements included effective renal plasma flow (ERPF) and glomerular filtration rate (GFR) by radionuclide study using I-131 hippuran and Tc-99m, according to the methods described by Schlegel and Gates, respectively. Effective renal blood flow [ERBF = ERPF/(1-Ht)], filtration fraction (FF = GFR/ERPF), and renal vascular resistance (RVR = MBP x 80/ERBF) were also calculated. Other hemodynamic measurements included cardiac index (CI), left ventricular (LV) ejection fraction (EF), and total peripheral resistance (TPR) measured by the first-pass radionuclide angiography technique. At the end of N or HCT administration significant decreases (p less than 0.001) in SBP, DBP, and MBP vs. baseline values were observed in both hypertensive groups. In the N group a significant decrease (p less than 0.01) in TPR and RVR, and significant increases (p less than 0.05) in CI, ERPF, and ERBF were observed. In the HCT group a significant decrease (p less than 0.05) in RVR was found without significant changes in other hemodynamic parameters. No important side effects were observed with either therapy. In conclusion, nitrendipine was effective in reducting blood pressure in mild to moderate hypertensive patients and exerted favorable effects on cardiac and renal function.

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Section: Discussionsupporting

confidence: 87%

“…Its effectiveness in lowering blood pressure has been well documented in animals and humans in acute and prolonged studies. It appears to be well tolerated and can improve left ventricular function [5][6][7]. Although the systemic effects of nitrendipine are generally well known, its renal effects are only now being characterized [8].…”

mentioning

confidence: 99%

Antihypertensive efficacy and effects of nitrendipine on cardiac and renal hemodynamics in mild to moderate hypertensive patients: Randomized controlled trial versus hydrochlorothiazide

Scaglione

Indovina

Parrinello

et al. 1992

Cardiovasc Drug Ther

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“…Converting enzyme inhibitors [1] and calcium antagonists [2] are commonly used in the treatment of arterial hypertension. These antihypertensive agents appear to act on small arteries that are preferentially damaged in hypertensive vascular disease.…”

mentioning

confidence: 99%

“…The influence of converting enzyme inhibitors and calcium antagonists on large arteries was studied at the upper limbs [2,3]. However, it is known that the blood vessels of upper and lower limbs can behave differently [4,5].…”

mentioning

confidence: 99%

Comparison of lisinopril and nitrendipine on the pulsatility index in mild essential arterial hypertension

Duprez

Buyzere

Brusselmans

et al. 1992

Cardiovasc Drug Ther

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A double-blind, randomized crossover study was performed in 21 patients with essential arterial hypertension. Nitrendipine 20 mg o.d. and lisinopril 20 mg o.d. were given in a randomized order during a period of each 8 weeks. Nitrendipine and lisinopril decreased systolic and mean arterial blood pressure to a similar level without a significant increase in heart rate. The mean diastolic blood pressure was smaller with the lisinopril treatment than with the nitrendipine treatment. The blood pressure decrease was maintained in the sitting and standing position. Furthermore, only nitrendipine decreased the pulsatility index at the tibial posterior arteries, while lisinopril did not influence it significantly. This finding means that mechanisms other than the blood-pressure lowering effect are involved in the decrease of the pulsatility index.

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Syst-Eur. A multicentre trial on the treatment of isolated systolic hypertension in the elderly: Objectives, protocol, and organization

Améry¹,

Birkenhäger²,

Bulpitt³

et al. 1991

Aging Clin Exp Res

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Review of Long-Term Trials with Nitrendipine

Cited by 6 publications

References 0 publications

Antihypertensive efficacy and effects of nitrendipine on cardiac and renal hemodynamics in mild to moderate hypertensive patients: Randomized controlled trial versus hydrochlorothiazide

Antihypertensive efficacy and effects of nitrendipine on cardiac and renal hemodynamics in mild to moderate hypertensive patients: Randomized controlled trial versus hydrochlorothiazide

Comparison of lisinopril and nitrendipine on the pulsatility index in mild essential arterial hypertension

Syst-Eur. A multicentre trial on the treatment of isolated systolic hypertension in the elderly: Objectives, protocol, and organization

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