Syst-Eur. A multicentre trial on the treatment of isolated systolic hypertension in the elderly: Objectives, protocol, and organization

Améry, A; Birkenhäger, W. H.; Bulpitt, CJ; Clément, Denis; Leeuw, Peter de; Dollery, C. T.; Fagard, Robert; Fletcher, A; Forette, Françoise; Leonetti, Gastone; O’Brien, Eoin; O’Malley, K; Rodicio, José L.; Rosenfeld, J; Staessen, Jan A; Strasser, T.; Terzoli, L.; Thijs, Lutgarde; Tuomilehto, Jaakko; Webster, J

doi:10.1007/bf03324024

Cited by 87 publications

(79 citation statements)

References 78 publications

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“…20, 21 The trial was approved by the Ethics Committees of the University of Leuven and of all participating centres and was implemented according to the principles of the declaration of Helsinki. Patients were eligible if they were at least 60 years old, had a systolic blood pressure when seated of 160-219 mm Hg with diastolic blood pressure below 95 mm Hg and a standing systolic blood pressure of at least 140 mm Hg.…”

Section: Methodsmentioning

confidence: 99%

Interaction between nonsteroidal anti-inflammatory drug intake and calcium-channel blocker-based antihypertensive treatment in the Syst-Eur trial

et al. 2001

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Objective: To assess the relationship between chronic intake of nonsteroidal anti-inflammatory drugs (NSAID) and outcome, in particular (gastrointestinal) bleeding and to investigate whether the effect of chronic NSAID intake was similar in untreated and treated elderly hypertensives. Methods: Eligible patients (у60 years, with systolic blood pressure 160-219 mm Hg and diastolic blood pressure Ͻ95 mm Hg) were randomised to active treatment or placebo. Active treatment consisted of nitrendipine, with the possible addition of enalapril, hydrochlorothiazide, or both, titrated or combined to reduce the sitting systolic blood pressure by at least 20 mm Hg to below 150 mm Hg. Patients never taking NSAIDs (n ‫؍‬ 2882) were compared with patients on chronic NSAID intake (n ‫؍‬ 861), defined as reporting NSAID intake on at least 50% of the patient forms.

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Section: Methodsmentioning

confidence: 99%

Interaction between nonsteroidal anti-inflammatory drug intake and calcium-channel blocker-based antihypertensive treatment in the Syst-Eur trial

et al. 2001

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“…8,9 After discontinuation of all anti-hypertensive drugs, the participants (у60 years) first entered a single-blind period on placebo, during which eligible patients maintained a sitting systolic BP (SBP) of 160-219 mm Hg and a diastolic BP (DBP) below 95 mm Hg on conventional measurement. Ambulatory pressure was recorded non-invasively at intervals not greater than 30 min.…”

Section: Methodsmentioning

confidence: 99%

Ambulatory blood pressure monitoring and postprandial hypotension in elderly patients with isolated systolic hypertension

et al. 1998

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The present analysis was undertaken to evaluate postprandial (PP) changes in blood pressure (BP) assessed with ambulatory BP monitoring (ABPM) in elderly subjects with isolated systolic hypertension (ISH) on conventional measurement. A total of 530 patients (335 women and 195 men, aged 60-100 years, median 70 years) who performed an ABPM during the placebo runin period of the Syst-Eur trial were included into the analysis. The PP changes in BP and heart rate (HR) were calculated by subtracting the mean systolic BP (SBP), diastolic BP (DBP) and HR in the 2 h preceding the main meal from the corresponding means covering the 2 h after the meal. The reproducibility of the postprandial fall in BP and heart rate (PPH) was assessed by contrasting the first and second ABPM in a subgroup of 147 patients who performed two ABPM's during the placebo run-in period. The mean SBP and DBP decreased and reached the nadir 2 h after the main meal while HR did not change. When PPH was assessed by comparing BP

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“…ISH was diagnosed by SYST-EUR criteria, ie, SBP 160 mm Hg or greater and DBP less than 95 mm Hg on three consecutive clinic visits. 2 Twenty-four hour ABPM was performed with a Spacelabs 90207 device, following discontinuation of anti-hypertensive agents for 72 h or more, depending on the type of medication. Daytime BP (06.00-23.00 h) was recorded every 15 min and night-time BP (23.00-06.00 h) every 30 min.…”

Section: Methodsmentioning

confidence: 99%

Ambulatory systolic blood pressure patterns in elderly hypertensives

1998

J Hum Hypertens

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In a recent study we found that patients with isolated systolic hypertension (ISH) had two patterns of systolic blood pressure (SBP) elevations by ambulatory BP monitoring (ABPM), sustained (S) and intermittent (I), the prognostic significance of which seems to be different. In the present study we tried to determine whether such patterns of SBP elevations may be detected among other hypertensives as well. Twenty-eight elderly patients (mean age 65.5 ± 5.1 years), nine with ISH, 10 with systolodiastolic hypertension (SDH), and nine with white coat hypertension (WCH), underwent ABPM. Average clinic BP in the ISH group was 184/83 mm Hg, in the SDH group 172/101 mm Hg, and in the WCH group 166/91 mm Hg, where as the ABPM averages were

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Syst-Eur. A multicentre trial on the treatment of isolated systolic hypertension in the elderly: Objectives, protocol, and organization

Cited by 87 publications

References 78 publications

Interaction between nonsteroidal anti-inflammatory drug intake and calcium-channel blocker-based antihypertensive treatment in the Syst-Eur trial

Interaction between nonsteroidal anti-inflammatory drug intake and calcium-channel blocker-based antihypertensive treatment in the Syst-Eur trial

Ambulatory blood pressure monitoring and postprandial hypotension in elderly patients with isolated systolic hypertension

Ambulatory systolic blood pressure patterns in elderly hypertensives

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