Review of cytomegalovirus coinfection in HIV-infected individuals in Africa

Grønborg, Helene Ladefoged; Jespersen, Sanne; Hønge, Bo Langhoff; Jensen-Fangel, Søren; Wejse, Christian

doi:10.1002/rmv.1907

Cited by 47 publications

(48 citation statements)

References 115 publications

(258 reference statements)

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“…In literature, both factors were reported to cause pneumonia. For the patients having widespread infiltration in radiology and widespread icy-glass appearance in thoracic computed tomography, we'd like to emphasize that the examinations for revealing both PCP and CMV factors should be performed in case of the presence of HIV/AIDS within the pre-diagnoses [14,15].…”

Section: Discussionmentioning

confidence: 99%

Lung Involvement of an Infectious Disease Having Increasing Incidence

Sertçelik¹,

Kuyucu²,

Afşar³

et al. 2017

Pulm Crit Care Med

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Backgroud: The incidence of HIV/AIDS infection is gradually increasing. One of the organs, which this infection targets, is the lungs. The lung involvement is seen in forms of recurrent pneumonia, pneumocystis jiroveci pneumonia, tuberculosis, and Kaposi sarcoma. Aim:The aim of this study is to draw attention on the importance of this subject while examining the cases, which we follow up in hospital. Study design:The data were obtained from the files and hospital records of all of HIV (+) patients, who have been hospitalized in our hospital in last 10 years. Methods: a retrospective studyResults: On the contrary with literature, most of our HIV (+) patients were diagnosed for P.jiroveci pneumonia. For the patients applying with complaints of cough, fever, and dyspnea and then found to have deep hypoxia and extensive infiltration in lung and oral candidiasis in physical examination, P.jiroveci pneumonia should be considered, thoracic CT -HRCT should be immediately taken and HIV test should be performed. Starting the accurate therapy as soon as possible significantly affects the clinical course. For the patients diagnosed for tuberculosis, the HIV serology should be requested, and consequently the antiretroviral treatment should be initiated according to the results.Conclusions: According to our study, 83% of the positivity of HIV was determined through the respiratory system complications of this infectious disease. It was aimed to draw attention to this infectious disease having increasing incidence, and to raise awareness that performing the required laboratory tests affects the prognosis.Moreover, 4 patients known to be HIV (+) gave no information on this subject in anamnesis. According to the practice of Ministry of Health, HIV serology shall not be performed unless the approval of patient is obtained. But, this also poses risk for the healthcare professionals. We believe that the required legal regulations taking healthcare professionals under protection should be prepared.

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Section: Discussionmentioning

confidence: 99%

Lung Involvement of an Infectious Disease Having Increasing Incidence

Sertçelik¹,

Kuyucu²,

Afşar³

et al. 2017

Pulm Crit Care Med

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“…61,62 CMV retinitis is by far the most frequent manifestation of CMV disease in HIV patients, but esophagitis, colitis, gastritis, encephalitis, hepatitis, and pneumonitis have also been described in this population. 61,63 Although CMV infection through the transfusion of blood products is certainly plausible, the actual risk of TT-CMV infection in HIV patients is unknown. 62,64 To the authors' knowledge, there are no documented cases in the literature of TT-CMV infection as a cause of primary CMV infection and CMV disease in HIV patients.…”

Section: Human Immunodeficiency Virus (Hiv) Patientsmentioning

confidence: 99%

Current strategies and future directions for the prevention of transfusion-transmitted cytomegalovirus

Harmon¹,

Cooling²

2017

IJCTM

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Cytomegalovirus (CMV) is a pervasive DNA virus that infects a significant portion of individuals worldwide, and may be transmitted through the transfusion of blood products. Although CMV infection is of little consequence in immunocompetent individuals, patients with an impaired immune system are at risk of significant morbidity and mortality. Unlike other blood-borne infectious agents, it is impractical to defer all CMV-positive individuals from blood donation as this would exclude a substantial number of otherwise eligible donors. Other methods such as transfusion of CMV-seronegative and leukoreduced blood products must be employed to prevent the transmission of CMV to at-risk patients. In this study, the widespread use of current strategies for the prevention of transfusion-transmitted CMV (TT-CMV) infection and the evidence to support these methods in various at-risk groups were reviewed. In addition, emerging pathogen inactivation technologies that have the potential to eliminate TT-CMV were also discussed.

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“…However, in immunocompromised patients, CMV is associated with significant morbidity and mortality. 1,8 In the viremic phase, CMV can affect many organ systems and cause interstitial pneumonia, hepatitis, abdominal pain, and diarrhea. 6,9 In addition, other clinical manifestations are associated with CMV infection, including pancytopenia, infectious mononucleosis syndrome, infection in the CNS, and retinitis.…”

Section: Introductionmentioning

confidence: 99%

Oral Ulcers Induced by Cytomegalovirus Infection: Report on Two Cases

Ribas¹,

Lima²

2017

J Dent Indones

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Human cytomegalovirus (CMV) is a virus that can compromise the lungs and the liver and cause infection in the gastrointestinal tract. In addition, this virus can cause infectious mononucleosis syndrome, infection in the CNS, and retinitis. Moreover, it has been associated with the development of oral hairy leukoplakia and ulcers. Objective: To report two cases of patients with HIV with oral manifestations associated with CMV infection. Case Report: In the first case, the patient sought medical attention, with complaints of weakness, fever, cough, and weight loss. In the second case, the patient complained of weakness and blurred vision for about a week. Both patients were infected with HIV and made irregular use of antiretroviral therapy. Several ulcers were observed in the mouth that caused much discomfort. The diagnosis of CMV infection was defined by the following tests: enzyme immunoassay fluorescence-CMV IgG and PCR for CMV in real time. Ganciclovir has been used in the treatment of patients, and oral ulcerations received symptomatic treatment. Conclusion: The dentist must be aware that CMV may also be responsible for the development of ulcers in the oral cavity, especially in immunocompromised patients.

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Review of cytomegalovirus coinfection in HIV-infected individuals in Africa

Cited by 47 publications

References 115 publications

Lung Involvement of an Infectious Disease Having Increasing Incidence

Lung Involvement of an Infectious Disease Having Increasing Incidence

Current strategies and future directions for the prevention of transfusion-transmitted cytomegalovirus

Oral Ulcers Induced by Cytomegalovirus Infection: Report on Two Cases

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