Review of Associations Between Type 2 Diabetes and Cancer

Bonagiri, Pranay R.; Shubrook, Jay H.

doi:10.2337/cd19-0077

Cited by 16 publications

(14 citation statements)

References 69 publications

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“…CRC is one of the most diagnosed cancers globally [ 48 ], with an increasing number of cases in recent decades [ 49 ]. In addition, T2D was associated with an increased incidence and prevalence of CRC, as hyperglycaemia is thought to have a significant role in the proliferation and expansion of colorectal cancer cells [ 50 ]. The influence of probiotic supplements on CRC is twofold.…”

Section: Resultsmentioning

confidence: 99%

Gestational Diabetes, Colorectal Cancer, Bariatric Surgery, and Weight Loss among Diabetes Mellitus Patients: A Mini Review of the Interplay of Multispecies Probiotics

et al. 2021

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Diabetes mellitus has been steadily increasing over the past decades and is one of the most significant global public health concerns. Diabetes mellitus patients have an increased risk of both surgical and post-surgical complications. The post-surgical risks are associated with the primary condition that led to surgery and the hyperglycaemia per se. Gut microbiota seems to contribute to glucose homeostasis and insulin resistance. It affects the metabolism through body weight and energy homeostasis, integrating the peripheral and central food intake regulatory signals. Homeostasis of gut microbiota seems to be enhanced by probiotics pre and postoperatively. The term probiotics is used to describe some species of live microorganisms that, when administered in adequate amounts, confer health benefits on the host. The role of probiotics in intestinal or microbial skin balance after abdominal or soft tissue elective surgeries on DM patients seems beneficial, as it promotes anti-inflammatory cytokine production while increasing the wound-healing process. This review article aims to present the interrelation of probiotic supplements with DM patients undergoing elective surgeries.

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Section: Resultsmentioning

confidence: 99%

Gestational Diabetes, Colorectal Cancer, Bariatric Surgery, and Weight Loss among Diabetes Mellitus Patients: A Mini Review of the Interplay of Multispecies Probiotics

et al. 2021

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“…In the recent years, both obesity and diabetes became highly prevalent worldwide [ 2 , 142 ]. Both of them are associated with elevated risk of cancer incidence and mortality [ 17 , 18 , 20 ]. Antidiabetic medications can modulate this risk via different mechanisms.…”

Section: Discussionmentioning

confidence: 99%

“…The methods and effectiveness of diabetes therapy and monitoring have also changed over the years, which has extended the life span of patients and also extended the time window for the development of malignant cancers in this population. Therefore, only the recent epidemiological data, published in this century, has given a more complete picture and documented a significantly higher incidence of certain cancers in people with diabetes, as well as with obesity [ 17 , 18 , 19 , 20 ]. In the last years, also the problem of oncological safety as well as oncoprotective properties of antidiabetic medications has become the subject of extensive discussion.…”

Section: Introductionmentioning

confidence: 99%

Diabetes, Antidiabetic Medications and Cancer Risk in Type 2 Diabetes: Focus on SGLT-2 Inhibitors

Dąbrowski

2021

IJMS

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In the last decade, cancer became the leading cause of death in the population under 65 in the European Union. Diabetes is also considered as a factor increasing risk of cancer incidence and mortality. Type 2 diabetes is frequently associated with being overweight and obese, which also plays a role in malignancy. Among biological mechanisms linking diabetes and obesity with cancer hyperglycemia, hyperinsulinemia, insulin resistance, increased levels of growth factors, steroid and peptide hormones, oxidative stress and increased activity of pro-inflammatory cytokines are listed. Antidiabetic medications can modulate cancer risk through directly impacting metabolism of cancer cells as well as indirectly through impact on risk factors of malignancy. Some of them are considered beneficial (metformin and thiazolidinedions—with the exception of bladder cancer); on the other hand, excess of exogenous insulin may be potentially harmful, while other medications seem to have neutral impact on cancer risk. Inhibitors of the sodium-glucose cotransporter-2 (SGLT-2) are increasingly used in the treatment of type 2 diabetes. However, their association with cancer risk is unclear. The aim of this review was to analyze the anticancer potential of this class of drugs, as well as risks of site-specific malignancies associated with their use.

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“…Furthermore, previous studies on HbA1c levels and cancer mortality have also been conflicting. Multiple studies have reported that HbA1c level is associated with an increased risk of poor cancer outcomes at several anatomical sites, including the breast and colon [ 15 , 16 , 17 , 18 ]. A study conducted among Singaporean Chinese also reported that HbA1c was related to cancer mortality [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Association of Glycosylated Hemoglobin Level and Cancer-Related Mortality in Patients without Diabetes

Yoo

Lee

et al. 2022

JCM

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Background: Previous studies have reported that abnormal glucose metabolism is associated with poor cancer outcomes. Glycated hemoglobin A1c (HbA1c) is an important indicator of glucose metabolism. This study aimed to investigate the relationship between nondiabetic HbA1c levels and cancer-related mortality. Methods: This was a retrospective cohort study of Koreans who attended an annual or biennial health checkup program. The study group was categorized based on the quintile of HbA1c level (Q1, 3.0–5.1%; Q2, 5.2–5.3%; Q3, 5.4%; Q4, 5.5–5.6%, Q5, 5.7–6.4%). Cancer-related mortality was determined using the mortality data from the Korea National Statistical Office. Participants with an established diagnosis of diabetes or cancer were excluded. Cancer-related mortality was assessed depending on each HbA1c level with adjustment for factors that could influence mortality. Results: A total of 589,457 participants were included in this study. During a median follow-up duration of 6.99 years, 1,712 cancer-related deaths were reported. The risk of cancer-related mortality was significantly higher in the Q5 group (hazard ratio (HR) 1.23, range 1.02–1.47 in model 1; HR 1.25, range 1.04–1.50 in model 2). HbA1c levels were linearly associated with cancer-related deaths (Ptrend = 0.021 in model 1; 0.013 in model 2). HbA1c level and colorectal, stomach, and lung cancer mortality exhibited a positive relationship, whereas liver cancer-related mortality showed an inverse relationship with HbA1c level (Ptrend = 0.001). Conclusions: Our study showed that abnormal glucose metabolism is significantly associated with cancer-related mortality, and its relationship varies with each type of cancer.

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Review of Associations Between Type 2 Diabetes and Cancer

Cited by 16 publications

References 69 publications

Gestational Diabetes, Colorectal Cancer, Bariatric Surgery, and Weight Loss among Diabetes Mellitus Patients: A Mini Review of the Interplay of Multispecies Probiotics

Gestational Diabetes, Colorectal Cancer, Bariatric Surgery, and Weight Loss among Diabetes Mellitus Patients: A Mini Review of the Interplay of Multispecies Probiotics

Diabetes, Antidiabetic Medications and Cancer Risk in Type 2 Diabetes: Focus on SGLT-2 Inhibitors

Association of Glycosylated Hemoglobin Level and Cancer-Related Mortality in Patients without Diabetes

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