Review of Amyotrophic Lateral Sclerosis, Parkinson’s and Alzheimer’s diseases helps further define pathology of the novel paradigm for Alzheimer’s with heavy metals as primary disease cause

Health hazards of child labor in the leather products and surgical instrument manufacturing industries of Sialkot, Pakistan

“…3). Mn is an important element for bone development, proper functioning of metabolic pathways, and enzymatic activities (SOD, glutamine synthase, and arginase) (Hamilton et al, 2000) while hyperaccumulation of Mn can cause Parkinson disease (Cavaleri, 2015). In the current study, the highest BAFs of Zn were in the hair samples at an average of 97 and 89% in the leather and surgical industries, respectively, and the lowest BAF was computed in the urine samples (average 9%) from the surgical industries.…”

Role of Alcohol Drinking in Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis

“…Based on the gender differences observed in ALS patients, several groups have reported that estrogen and hormonal mechanisms may also play a potential role [119]. The effects of various environmental factors, including smoking [120], trauma [121], physical activity [122], pesticides [123] and heavy metals [124] have been investigated; smoking and pesticides are potential risk factors.…”

Prevalence of Amyotrophic Lateral Sclerosis — United States, 2012–2013

“…Whites, males, non-Hispanics, those aged >60 years, and those with a family history of the disease are more likely to develop ALS (1,6). Previous exposure to heavy metals (e.g., lead and chromium), pesticides, and ß-N-methylamino-L-alanine (BMAA) produced by cyanobacteria also have been associated with an increased risk for ALS (7)(8)(9)(10)(11). Military service continues to be a possible risk factor for ALS; however, no strong evidence has been found linking etiology with service (12)(13)(14)(15).…”