Review: Long Noncoding RNAs in the Regulation of Inflammatory Pathways in Rheumatoid Arthritis and Osteoarthritis

Knockdown of Long Non-Coding RNA RP11-445H22.4 Alleviates LPS-Induced Injuries by Regulation of MiR-301a in Osteoarthritis

“…Recently, increasing evidences demonstrated that lncRNAs are key elements of pathologic and physiologic processes, and are vital regulators of inflammatory response [9, 10]. Previous study reported that cartilage injury-related lncRNA (lncRNA-CIR) was higher expressed in chondrocytes induced by interleukin-1(IL-1), and inhibited the formation of collagen and aggrecan in OA [11].…”

Downregulation of long noncoding RNA LOC101928134 inhibits the synovial hyperplasia and cartilage destruction of osteoarthritis rats through the activation of the Janus kinase/signal transducers and activators of transcription signaling pathway by upregulating IFNA1

“…LncRNAs, a type of noncoding RNAs, could regulate gene expression via transcription, translation, and epigenetic modifications of DNA (Pearson & Jones, ). Some studies have provided convincing evidence that lncRNAs, rich in mammalian transcriptomes, exert a critical role in various biological processes including differentiation and development, and also leading to diseases when they are misregulated (Dey et al, ; Johnsson, Lipovich, Grander, & Morris, ).…”

“…Some studies have provided convincing evidence that lncRNAs, rich in mammalian transcriptomes, exert a critical role in various biological processes including differentiation and development, and also leading to diseases when they are misregulated (Dey et al, ; Johnsson, Lipovich, Grander, & Morris, ). Notably, it has been indicated that lncRNAs could modulate pathologic and physiologic processes, and may involve in the inflammatory response or inflammatory pathways in rheumatoid arthritis (RA) and OA (Pearson & Jones, ). It has been known that lncRNA LOC101928134 is located in the region of chromosome 15q13.3 according to databases.…”

The expression levels of long noncoding RNAs lnc0640 and lnc5150 and its gene single‐nucleotide polymorphisms in rheumatoid arthritis patients

“…1 Despite many decades of research, the pathogenesis underlying RA remains largely unknown, although several inflammatory cytokines, such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL- 6), have been reported to contribute to the RA development. 1 Despite many decades of research, the pathogenesis underlying RA remains largely unknown, although several inflammatory cytokines, such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL- 6), have been reported to contribute to the RA development.…”

“…1 Despite many decades of research, the pathogenesis underlying RA remains largely unknown, although several inflammatory cytokines, such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL- 6), have been reported to contribute to the RA development. [4][5][6][7] Moreover, lncRNAs have been shown to play varied critical roles including inhibition of transcriptional machinery, affecting mRNA stability, regulating epigenetic DNA modifications, enhancing RNA degradation, and directing the apoptosis of different immune cells, in a variety of biological and cellular processes. Several studies have found that lncRNAs could be significant regulatory factors to inflammatory gene expression in innate immune system and play important roles in multiple autoimmune diseases.…”