Review:<i>In Vivo</i>Effects of Extracorporeal Shock Wave Lithotripsy: Animal Studies

Preminger, Glenn M.

doi:10.1089/end.1993.7.375

Cited by 14 publications

(2 citation statements)

References 32 publications

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“…The final outcome of such specific pathologies has been extensively evaluated in a large number of both clinical and experimental studies. 2,7,8 Morphologic renal changes after SWL may be divided into acute (primary) and long-term (secondary) lesions. The various renal structures (glomeruli, tubules, and vessels) were judged in relation to their intrarenal location.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Basal Membrane Antibody (Immunoglobulin G) Formation after High-Energy Shockwave Application in Rats

Sarıca¹,

Türkölmez²,

Koşar³

et al. 1998

Journal of Endourology

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To evaluate the immune pathologic effects of high-energy shockwave (HESW) application on glomerular and tubular basal membrane antibody (IgG) formation, an experimental study on rats has been performed. Following application of different numbers of shockwaves (100-200-500), the presence of antibody was examined with the direct immunofluorescent technique 2 weeks and 3 months postprocedure. Whereas specimens examined after 2 weeks showed antibody formation in only one animal (500 HESWs), being located in the tubular tissues, all treated kidneys demonstrated various degrees of antibody formation in both tubular and glomerular tissues after 3 months. Antibody formation had a close relation to the number of HESWs applied and the time of examination after shockwave application. Apart from the well-defined functional and morphologic side effects of shockwave therapy, the possibility of immunologic alterations after this form of therapy has to be evaluated thoroughly in both clinical and experimental studies.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Basal Membrane Antibody (Immunoglobulin G) Formation after High-Energy Shockwave Application in Rats

Sarıca¹,

Türkölmez²,

Koşar³

et al. 1998

Journal of Endourology

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“…[1][2][3][4][5][6][7][8][9][10][11][12] The aim of the present study was to develop an in vitro tissue model that enables reproducible histopathologic evaluation of SW-induced renal trauma and to find a substitute for animal experiments.…”

Section: Introduction E Xtracorporial Shockwave Lithotripsy Hasmentioning

confidence: 99%

The Isolated Perfused Kidney: Anin VitroTest System for Evaluation of Renal Tissue Damage Induced by High-Energy Shockwaves Sources

Bergsdorf

Thüroff

Chaussy

2005

Journal of Endourology

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Most of our knowledge of shockwave-induced renal damage is based on animal experiments and clinical observation. We developed a tissue model using isolated porcine kidneys perfused with Berliner Blau dye in physiologic saline using a Ureteromat Perez-Castro peristaltic pump connected to the renal artery. Reproducible results were obtained under a variety of experimental conditions. Further refinements of the model might consist of interposition of tissue layers in the shockwave path or simulation of ventilatory movements.

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Lithotripsy

Weizer¹,

Preminger²

2006

Encyclopedia of Medical Devices and Instrumentation

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Shock wave lithotripsy (SWL) is a noninvasive method for the treatment of stones within the urinary tract. Since its clinical introduction over 25 years ago, SWL has revolutionized the way in which renal and ureteral stones are managed. Despite the wide array of currently available lithotripters, all rely on the same fundamentals of acoustic physics. Shock waves (i.e., high pressure sound waves) consisting of a sharp peak in positive pressure followed by a trailing negative wave are generated extracorporeally and passed through the body to fragment stones. Ultrasound or fluoroscopy are used to focus the shock wave on the stone inside the patients’ body. When the shock wave encounters the kidney stone, the force generated in the plane of the shock wave places stress on the imperfections within the stone resulting in compression‐induced tensile cracking. In addition, shock waves can cause microbubble formation on the surface of the stone. As the shock wave passes, these bubbles collapse releasing secondary shock waves or microjets impinging against the stone that result in stone destruction. While these mechanisms result in stone fragmentation, they may also be responsible for kidney injury, by primarily damaging small blood vessels within the kidney. Modifications to the design of the original lithotripter (Dornier HM3, Dornier MedTech America, Inc., Kennesaw, GA) resulted in improved patient comfort, but inferior stone fragmentation. Better understanding of the mechanisms of stone fragmentation and tissue injury caused by SWL have resulted in modifications to lithotripters that make the current machines safer and more effective.

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Review:In VivoEffects of Extracorporeal Shock Wave Lithotripsy: Animal Studies

Cited by 14 publications

References 32 publications

Evaluation of Basal Membrane Antibody (Immunoglobulin G) Formation after High-Energy Shockwave Application in Rats

Evaluation of Basal Membrane Antibody (Immunoglobulin G) Formation after High-Energy Shockwave Application in Rats

The Isolated Perfused Kidney: Anin VitroTest System for Evaluation of Renal Tissue Damage Induced by High-Energy Shockwaves Sources

Lithotripsy

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