Review Hyperthermia and liposomes

Kong, Garheng; Dewhirst, Mark W.

doi:10.1080/026567399285558

Cited by 237 publications

(26 citation statements)

References 23 publications

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“…Light‐absorbing photothermal agents can serve as heat carrier for local hyperthermia. Like PDT, mild hyperthermia improves vascular perfusion and enhances the extravasation of nanoparticles into the tumor interstitial space 230, 231, 232. Kong et al demonstrated that liposomal extravasation rate is affected by particle size, temperature and timing between hyperthermia and liposome administration 231.…”

Section: Nanoparticle‐mediated Cptmentioning

confidence: 99%

Chemophototherapy: An Emerging Treatment Option for Solid Tumors

et al. 2016

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Near infrared (NIR) light penetrates human tissues with limited depth, thereby providing a method to safely deliver non‐ionizing radiation to well‐defined target tissue volumes. Light‐based therapies including photodynamic therapy (PDT) and laser‐induced thermal therapy have been validated clinically for curative and palliative treatment of solid tumors. However, these monotherapies can suffer from incomplete tumor killing and have not displaced existing ablative modalities. The combination of phototherapy and chemotherapy (chemophototherapy, CPT), when carefully planned, has been shown to be an effective tumor treatment option preclinically and clinically. Chemotherapy can enhance the efficacy of PDT by targeting surviving cancer cells or by inhibiting regrowth of damaged tumor blood vessels. Alternatively, PDT‐mediated vascular permeabilization has been shown to enhance the deposition of nanoparticulate drugs into tumors for enhanced accumulation and efficacy. Integrated nanoparticles have been reported that combine photosensitizers and drugs into a single agent. More recently, light‐activated nanoparticles have been developed that release their payload in response to light irradiation to achieve improved drug bioavailability with superior efficacy. CPT can potently eradicate tumors with precise spatial control, and further clinical testing is warranted.

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Section: Nanoparticle‐mediated Cptmentioning

confidence: 99%

Chemophototherapy: An Emerging Treatment Option for Solid Tumors

et al. 2016

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“…It has also been proposed that physiologically-present proteins act at domain boundaries to disrupt the liposome and increase release 105 . These mechanisms would tend to favour slow, diffusive release, while the disruption in the membrane inherent to the phase transition itself could allow a transitory “burst” of release.…”

Section: Technologymentioning

confidence: 99%

Membrane adhesion and the formation of heterogeneities: biology, biophysics, and biotechnology

Gordon

O’Halloran

Shindell

2015

Phys. Chem. Chem. Phys.

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Membrane adhesion is essential to many vital biological processes. Sites of membrane adhesion are often associated with heterogeneities in the lipid and protein composition of the membrane. These heterogeneities are thought to play functional roles by facilitating interactions between proteins. However, the causal links between membrane adhesion and membrane heterogeneities are not known. Here we survey the state of the field and indicate what we think are understudied areas ripe for development.

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“…First, by regulating physical barriers including blood flow and extravasation, the tumor vasculature limits the delivery of therapeutic agents spanning several orders of magnitude in size, including antibodies, nanoparticle carriers, and conventional chemotherapies. [3-7] Second, many solid tumors are dependent on the host vasculature for supplying nutrients and oxygen during neoangiogenesis. These features make the vasculature a generalized and genetically-stable target for solid tumors.…”

Section: Introductionmentioning

confidence: 99%

Endothelial Thermotolerance Impairs Nanoparticle Transport in Tumors

et al. 2015

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The delivery of diagnostic and therapeutic agents to solid tumors is limited by physical transport barriers within tumors, and such restrictions directly contribute to decreased therapeutic efficacy and the emergence of drug resistance. Nanomaterials designed to perturb the local tumor environment with precise spatiotemporal control have demonstrated potential to enhance drug delivery in preclinical models. Here, we investigated the ability of one class of heat-generating nanomaterials called plasmonic nanoantennae to enhance tumor transport in a xenograft model of ovarian cancer. We observed a temperature-dependent increase in the transport of diagnostic nanoparticles into tumors. However, a transient, reversible reduction in this enhanced transport was seen upon re-exposure to heating, consistent with the development of vascular thermotolerance. Harnessing these observations, we designed an improved treatment protocol combining plasmonic nanoantennae with diffusion-limited chemotherapies. Using a microfluidic endothelial model and genetic tools to inhibit the heat-shock response (HSR), we found that the ability of thermal preconditioning to limit heat-induced cytoskeletal disruption is an important component of vascular thermotolerance. This work therefore highlights the clinical relevance of cellular adaptations to nanomaterials and identifies molecular pathways whose modulation could improve the exposure of tumors to therapeutic agents.

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Review Hyperthermia and liposomes

Cited by 237 publications

References 23 publications

Chemophototherapy: An Emerging Treatment Option for Solid Tumors

Chemophototherapy: An Emerging Treatment Option for Solid Tumors

Membrane adhesion and the formation of heterogeneities: biology, biophysics, and biotechnology

Endothelial Thermotolerance Impairs Nanoparticle Transport in Tumors

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