Review: Bioanalytical applications of biomolecule-functionalized nanometer-sized doped silica particles

Knopp, Dietmar; Tang, Dianping; Nießner, Reinhard

doi:10.1016/j.aca.2009.05.037

Cited by 364 publications

(220 citation statements)

References 252 publications

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“…Inorganic nanomaterials also possess some outstanding properties of http://bmbreports.org large surface-to-volume ratio and high electrical conductivity that provides electron communication of electrical signals (15,69,70). Thus recent years witness the vigorous applications of inorganic nanomaterials in the development of biosensors (71). To develop biosensor systems, oxidizing enzymes (i.e., glucose oxidase and horseradish peroxidase) are conducted to sensing elements because they do not consume itself during the recognition event (catalyzing reaction of O2 or H2O2), hence can be reused thus providing a long lifetime for the device (43,45,72).…”

Section: Biosensorsmentioning

confidence: 99%

Inorganic nanomaterial-based biocatalysts

Lee

Lee²,

Chang³

et al. 2011

BMB Reports

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Over the years, nanostructures have been developed to enable to support enzyme usability to obtain highly selective and efficient biocatalysts for catalyzing processes under various conditions. This review summarizes recent developments in the nanostructures for enzyme supporters, typically those formed with various inorganic materials. To improve enzyme attachment, the surface of nanomaterials is properly modified to express specific functional groups. Various materials and nanostructures can be applied to improve both enzyme activity and stability. The merits of the incorporation of enzymes in inorganic nanomaterials and unprecedented opportunities for enhanced enzyme properties are discussed.

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Section: Biosensorsmentioning

confidence: 99%

Inorganic nanomaterial-based biocatalysts

Lee

Lee²,

Chang³

et al. 2011

BMB Reports

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“…For example, single molecule imaging of mRNA has been achieved by tagging an mRNA with 24 units of MS2 aptamers, which accumulate MS2-GFP fusion proteins on the mRNA (Fusco et al, 2003). On the other hand, a nanoparticle doped with thousands of fluorescent dyes can greatly increase the signal by several orders of magnitude (Knopp et al, 2009). Such nanoparticle-aptamer conjugates, if biocompatible, have the potential to dramatically amplify the signal for sensitive imaging.…”

Section: Signal Amplificationmentioning

confidence: 99%

Aptamer-based molecular imaging

Wang

Ray

2012

Protein Cell

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Molecular imaging has greatly advanced basic biology and translational medicine through visualization and quantification of single/multiple molecular events temporally and spatially in a cellular context and in living organisms. Aptamers, short single-stranded nucleic acids selected in vitro to bind a broad range of target molecules avidly and specifically, are ideal molecular recognition elements for probe development in molecular imaging. This review summarizes the current state of aptamer-based biosensor development (probe design and imaging modalities) and their application in imaging small molecules, nucleic acids and proteins mostly in a cellular context with some animal studies. The article is concluded with a brief discussion on the perspective of aptamer-based molecular imaging.

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“…These conjugates were also very good for in vitro targeting of cancer cells. Knop et al [68] reviewed the bioanalytical applications of silica particles and concluded that the biomolecule-functionalized silica nanoparticles will become increasingly accepted as labeling reagents in bioanalysis and bioimaging because of their excellent intrinsic optical and chemical properties.…”

Section: Silicamentioning

confidence: 99%

Immobilization of biomolecules on the surface of inorganic nanoparticles for biomedical applications

Xing

Chang

Kang

2010

Science and Technology of Advanced Materials

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Various inorganic nanoparticles have been used for drug delivery, magnetic resonance and fluorescence imaging, and cell targeting owing to their unique properties, such as large surface area and efficient contrasting effect. In this review, we focus on the surface functionalization of inorganic nanoparticles via immobilization of biomolecules and the corresponding surface interactions with biocomponents. Applications of surface-modified inorganic nanoparticles in biomedical fields are also outlined.

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Review: Bioanalytical applications of biomolecule-functionalized nanometer-sized doped silica particles

Cited by 364 publications

References 252 publications

Inorganic nanomaterial-based biocatalysts

Inorganic nanomaterial-based biocatalysts

Aptamer-based molecular imaging

Immobilization of biomolecules on the surface of inorganic nanoparticles for biomedical applications

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